| DC66324 |
WAY-358024
Featured
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GSK-3b inhibitors; GSK-3b inhibitors; |
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| DC66325 |
CB2R PAM
Featured
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CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain. |
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| DC66326 |
Ropidoxuridine
Featured
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Ropidoxuridine (IPdR) is a novel orally available, halogenated thymidine analog and is a potential radiosensitizer for use in human tumors. |
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| DC66327 |
Antibacterial agent 125
Featured
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Antibacterial agent 125 is an antibacterial agent. Antibacterial agent 125 has a potent antimicrobial activity against clinically relevant Gram-positive pathogens with MIC50 values range from 0.25 - 8 μM. Antibacterial agent 125 can be used for the research of antimicrobial resistance. |
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| DC66328 |
OTS514 hydrochloride
Featured
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OTS514 hydrochloride is a highly potent TOPK inhibitor, which inhibits TOPK kinase activity with a median inhibitory concentration (IC50) value of 2.6 nM. OTS514 hydrochloride strongly suppresses the growth of TOPK-positive cancer cells. OTS514 hydrochloride induces cell cycle arrest and apoptosis. |
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| DC66329 |
Martinostat hydrochloride
Featured
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Martinostat (hydrochloride) is a inhibitor of HDAC that can be labeled with radionuclides for diagnostic applications. |
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| DC66330 |
Martinostat
Featured
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Martinostat is a histone deacetylase imaging agent. |
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| DC66331 |
NSC 31150
Featured
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| DC66332 |
STM2120
Featured
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STM2120 is a METTL3-METTL14 inhibitor with an IC50 of 64.5 μM. |
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| DC66333 |
ML 315 hydrochloride
Featured
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ML 315 hydrochloride is a selective dual inhibitor of CDK and DYRK with IC50s of 68 nM and 282 nM, respectively. ML 315 is used in cancer and neurological disease research. |
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| DC66334 |
KA2507 monohydrochloride
Featured
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KA2507 hydrochloride is a potent and highly selective inhibitor of HDAC6 (IC50=2.5 nM) with no significant toxicities. KA2507 hydrochloride shows antitumor efficacy and immune modulatory effects. |
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| DC66335 |
ANO61
Featured
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ANO61 is a dibenzyl formamide derivative, which exhibits an antiplatelet efficacy through modulation of thrombin-induced Ca2+ response with an IC50 of 47.7 μM. |
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| DC66336 |
BD1063 HCl
Featured
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BD1063 is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 9 ± 1 nM for the sigma-1 receptor and more than 49 times selectivity over the sigma-2 receptor. Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with BD1063 significantly decreases the convulsivity and lethality of cocaine. In other animal studies, BD1063 blocks the effects of MDMA, and reduces alcohol intake in rodent models of alcoholism. |
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| DC66337 |
GLUT4 activator 2
Featured
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GLUT4 activator 2 (C59) is an insulin sensitizer, which can be used for research of diabetic diseases. GLUT4 activator 2 improves glucose uptake and insulin sensitivity in rodents. GLUT4 activator 2 interacts with Unc119 and Unc119B resulting in increased insulin sensitivity and GLUT4 translocation. |
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| DC66338 |
GW549390X
Featured
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GW549390X is a dual inhibitor of Fluc and VEGFR2 with IC50 of 0.26 μM and 1.2 μM, respectively. GW549390X can bind to the ATP pocket of FLuc through the aniline side chain and is an ATP-competitive inhibitor of Fluc. GW549390X acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, with potential implications for Fluc reporter assays. |
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| DC66339 |
N-Desmethyl-U-47700
Featured
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N-Desmethyl-U-47700 is the primary metabolite of U-47700 (an opioid agonist). |
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| DC66340 |
CZL80
Featured
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CZL80, a brain-penetrable caspase-1 inhibitor with an IC50 of 0.01 μM, could be used in the study of febrile seizures and later enhanced epileptogenic susceptibility. |
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| DC66341 |
P2X4 antagonist-1
Featured
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P2X4 antagonist-1 (Compound 24) is an antagonist for P2X4 with IC50 of 15 nM. |
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| DC66342 |
N-Benzyl-6-chloropyrimidin-4-amine
Featured
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N-Benzyl-6-chloropyrimidin-4-amine is a pyrimidine derivative. |
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| DC66343 |
Antiviral agent 52
Featured
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Antiviral agent 52 (Compound 30) is a Chlorcyclizine (HY-112067) derivative that exhibits antiviral activity against hepatitic C virus (HCV) with an EC50 of 17 nM. Antiviral agent 52 reveals cytotoxicity in cell Huh7.5.1 with CC50 of 21.3 μM. |
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| DC66344 |
(E/Z)-MCB-613
Featured
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(E/Z)-MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. (E/Z)-MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. (E/Z)-MCB-613 is a cytotoxic molecule that plays an important role in cancer. |
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| DC66345 |
CAY10464
Featured
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CAY10464 (AHR antagonist 7; compound 4j) is a selective and high-affinity aryl hydrocarbon receptor (AhR) antagonist with a Ki of 1.4 nM. |
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| DC66346 |
11β-HSD2-IN-2
Featured
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11β-HSD2-IN-2 (compound 3) is a selective inhibitor for 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) with an IC50 of 300 nM. |
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| DC66347 |
HDL-16
Featured
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HDL-16 is a potent P2Y14R antagonist with an IC50 of 0.3095 nM. HDL-16 ameliorates DSS (HY-116282C)-induced colitis through suppressing necroptosis of intestinal epithelium cells (IECs) and protecting mucosal barrier function. |
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| DC66348 |
Scarlet 808
Featured
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Scarlet 808 (Bronze Red; Shanghai Bronze Red) is a naphthol red pigment. Scarlet 808 can be used for coloring coatings, leather, and latex paints. It has the advantages of high tinting power, good hiding power, alkali resistance, and acid resistance. |
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| DC66349 |
EBV lytic cycle inducer-1
Featured
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Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (compound C7) is an iron-chelatoe-like compound. Dp44mT cooperates with HDAC inhibitor Romidespin (HY-15149) and SAHA to induce EBV lytic cycle. Dp44mT reactivates EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers. |
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| DC66350 |
LM-41
Featured
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LM-41 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2. LM-41 inhibits migration of human MDA-MB-231 breast cancer cells. |
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| DC66351 |
NorA-IN-1
Featured
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NorA-IN-1 (Compound 16) is a NorA inhibitor. NorA-IN-1 inhibits NorA efflux pump in everted membrane vesicles. NorA-IN-1 can be used for research of multidrug resistance. |
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| DC66352 |
Methyl 3,4-dimethoxycinnamate
Featured
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Methyl 3,4-dimethoxycinnamate is an inhibitor of uredospore germination. Methyl 3,4-dimethoxycinnamate also inhibits global DNA methylation in in Hep3B cells. |
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| DC66353 |
Methyl 3,4,5-trimethoxycinnamate
Featured
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Methyl 3,4,5-trimethoxycinnamate (Compound III) is a natural compound with hydroxyl radical-scavenging effects. |
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