| DC66354 |
RIOK2-IN-1
Featured
|
RIOK2-IN-1 (com 4) is a potent and selective RIOK2 inhibitor (Kd=150 nM), but has low cellular activity (IC50=14,600 nM). RIOK2 is an atypical kinase associated with a variety of human cancers and is involved in ribosome maturation and cell cycle progression. The small molecule inhibitor CQ211 (HY-147655), an improvement of RIOK2-IN-1 as the lead compound, has good in vivo and in vitro activity, inhibits the proliferation of MKN-1 and HT-29 cancer cells, and can xenograft MKN in mice -1 model inhibits tumor progression. |
|
| DC66355 |
hRIO2 kinase ligand-1
Featured
|
hRIO2 kinase ligand-1 (com 9) is a ligand of hRIO2 kinase, with a Kd value of 520 nM. |
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| DC66356 |
(E)-Benzyl ferulate
Featured
|
(E)-Benzyl ferulate is a phenolic ester that can be isolated from Thai propolis. |
|
| DC66357 |
Sirtuin-1 inhibitor 1
Featured
|
Sirtuin-1 inhibitor 1 (Compound 8) is an inhibitor of Sirtuin-1 that plays important roles in obesity-induced diabetes and aging-related diseases. |
|
| DC66358 |
Acid Red 4
Featured
|
Acid Red 4 is an azo dye. The wavelength of maximum absorbance for Acid Red 4 is 508 nm. |
|
| DC66359 |
UCCF-853
Featured
|
UCCF-853 is a CFTR modulator. |
|
| DC66360 |
CCR-11
Featured
|
CCR-11 is an antibacterial agent. CCR-11 can inhibit the proliferation of B. subtilis cells with an IC50 value of 1.2 μM. CCR-11 inhibits HeLa cell proliferation with an IC50 value of 18.1 μM. CCR-11 inhibits bacterial cytokinesis by inhibiting FtsZ assembly. CCR-11 can be used for the research of FtsZ-targeted antibacterial agents. |
|
| DC66361 |
mAChR antagonist 1
Featured
|
mAChR antagonist 1 (compound 4a) is a mAChR antagonist with Ki values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively. |
|
| DC66362 |
A3373
Featured
|
A3373, a novel chemical inhibitor of Phospholipase D1 (PLD1) and PLD2, with IC50 of 325 nM and 15.15?μM, respectively, inhibits LPS-induced immune response and plays important roles in autoimmune arthritis, bone demineralization and osteoclastogenesis. |
|
| DC66363 |
MAO-B-IN-26
Featured
|
MAO-B-IN-26 (Compound IC9) is a MAO-B and acetylcholinesterase inhibitor. MAO-B-IN-26 protects SH?SY5Y cells against Aβ induced cytotoxicity, morphological changes, ROS generation and membrane damage. MAO-B-IN-26 also inhibits Aβ induced autophagy and apoptosis. MAO-B-IN-26 can be used as a neuroprotective agent against Alzheimer’s disease. |
|
| DC66364 |
STING-IN-7
Featured
|
STING-IN-7 (compound 21) is a potent STING inhibitor with an IC50 of 11.5 nM. STING-IN-7 inhibits the phosphorylation of STING and interferon regulatory factor 3 (IRF3). |
|
| DC66365 |
PP5-IN-1
Featured
|
PP5-IN-1 (Compound P053) is a competitive inhibitor of Serine/threonine protein phosphatase-5 (PP5) that binds to its catalytic domain and causes apoptosis in renal cancer. |
|
| DC66366 |
TNKS-2-IN-2
Featured
|
TNKS-2-IN-2 is a potent and selective inhibitor of TNKS2 with an IC50 of 22 nM. |
|
| DC66367 |
RORγ inverse agonist 1
Featured
|
RORγ inverse agonist 1 is the inverse agonist of RORγ. |
|
| DC66368 |
sulfo-SPDB-DM4
Featured
|
sulfo-SPDB-DM4 is a agent-linker conjugate for ADC by using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker. |
|
| DC66369 |
WAY-232897
Featured
|
WAY-232897 is an active molecule for the study of amyloid diseases and synucleinopathies. |
|
| DC66370 |
WAY-639418
Featured
|
WAY-639418 is an active molecule for the study of amyloid diseases and synucleinopathies. |
|
| DC66371 |
WAY-312858
Featured
|
WAY-312858 is an active molecule for the study of amyloid diseases and synucleinopathies. |
|
| DC66372 |
N-(2-Hydroxyphenyl)picolinamide
Featured
|
N-(2-Hydroxyphenyl)picolinamide is an active molecule. |
|
| DC66373 |
WAY-658674
Featured
|
WAY-658674 is an active molecule for the study of amyloid diseases and synucleinopathies. |
|
| DC66374 |
WAY-323756
Featured
|
WAY-323756 is an active molecule for research into amyloid diseases and synucleinopathies. |
|
| DC66375 |
WAY-309236
Featured
|
WAY-309236 is an active molecule for the study of amyloid diseases and synucleinopathies. |
|
| DC66376 |
N-Cyclopropyl-4-iodobenzamide
Featured
|
N-Cyclopropyl-4-iodobenzamide is an active molecule. |
|
| DC66377 |
WAY-620147
Featured
|
WAY-620147 (compound 6) is an N-(2-morpholinoethyl)nicotinamide derivative that inhibits monoamine oxidase (Monoamine Oxidase). WAY-620147 inhibits MAO-A and MAO-B with IC50s of 26 μM and 55 μM, respectively. |
|
| DC66378 |
WAY-637940
Featured
|
WAY-637940 is an active molecule. |
|
| DC66379 |
WAY-604603
Featured
|
WAY-604603 is an active molecule. |
|
| DC66380 |
WAY-621924
Featured
|
WAY-621924 is an active molecule. |
|
| DC66381 |
WAY-354574
Featured
|
WAY-354574 is an active molecule targeting deacetylase (Sirtuin) for the study of Huntington's disease (HD). |
|
| DC66382 |
WAY-608106
Featured
|
WAY-608106 is an active molecule. |
|
| DC66383 |
Topoisomerase I inhibitor 9
Featured
|
Topoisomerase I inhibitor 9 (compound 3d) is a leishmanial topoisomerase IB inhibitor. Topoisomerase I inhibitor 9 has antileishmanial activity against L. donovani promastigotes, with the IC50 of 34.81μM. |
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