| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC67080 | Tri-GalNAc(OAc)3-Perfluorophenyl Featured | Tri-GalNAc(OAc)3-Perfluorophenyl is a pentafluorophenyl modified Tri-GalNAc(OAc)3 (HY-148118), a tri-GalNAc ligand that can be used for the synthesis of GalNAc-LYTAC. GalNAc-LYTAC engages the asialoglycoprotein receptor for targeted protein degradation. tri-GalNAc: triantenerrary N-acetylgalactosamine; LYTAC: lysosome-targeting chimera. |
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| DC60672 | BAY-184 Featured | BAY-184 is the first, potent and selective acylsulfonamide-benzofuran in vivo-active KAT6A/B inhibitor with IC50 of 71 nM. |
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| DC67081 | CY5-SE Featured | Cy5-SE (Cy5 NHS Ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm):649, Emission (nm): 670. |
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| DC60674 | XY-07-191 Featured | XY-07-191 is the negative control of XY-07-35. |
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| DC60675 | MrTAC-HaXS8 Featured | MrTAC-HaXS8 is a methylarginine targeting chimera (MrTAC). MrTAC-HaXS8 induces lysosomal GSK3β proteolysis with DC50 of 11.3 nM. |
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| DC60676 | MRT-6160 Featured | MRT-6160 is a first-in-class molecular glue degrader that specifically targets VAV1 for proteasomal degradation with DC50 of 7 nM. |
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| DC60677 | Compound 31 (MerTK inhibitor) Featured | Compound 31 (MerTK inhibitor) is a potent azetidine-benzoxazole MerTK inhibitor with IC50 of 1.3 nM. Compound 31 potently engages the target in vivo and demonstrates single agent activity in the immune-driven MC-38 murine syngeneic tumor model. |
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| DC60678 | ALG-055009 Featured | ALG-055009 is a potent and selective thyroid hormone receptor beta (THR-β) agonist with EC50 of 0.063 μM. ALG-055009 is highly metabolically stable, with good permeability and a relatively low efflux ratio. |
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| DC60679 | DYR684 Featured | DYR684 is a potent, selective, and metabolically stable PROTAC of the protein kinases DYRK1A and DYRK1B with Kd of 6.3 nM and 16 nM, respectively. |
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| DC67083 | INDEX NAME NOT YET ASSIGNED Featured |
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| DC60680 | AMG 193 Featured | AMG 193 is an orally bioavailable and MTA-cooperative PRMT5 inhibitor with IC50 of 0.107 μM in MTAP-null cells, which is about 40-fold selective over MTAP WT cells. |
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| DC60681 | SD-436 Featured | SD-436 is a highly potent and selective STAT3 degrader with DC50 of 0.1 nM in human PBMCs and displays >10,000-fold degradation selectivity for STAT3 over other STAT proteins. |
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| PR0047243 | ERD-1233 Featured | ERD-1233 is a potent and orally efficacious estrogen receptor α (ERα) degrader with DC50 of 0.9 nM. ERD-1233 does not display any liability in CYP inhibition, hERG inhibition, and microsomal and plasma stability. ERD-1233 effectively reduces ER protein in ER+ tumors and achieves tumor regression in the ER wild-type MCF-7 xenograft tumor model. ERD-1233 is a potent and orally efficacious estrogen receptor α (ERα) degrader with DC50 of 0.9 nM. ERD-1233 does not display any liability in CYP inhibition, hERG inhibition, and microsomal and plasma stability. ERD-1233 effectively reduces ER protein in ER+ tumors and achieves tumor regression in the ER wild-type MCF-7 xenograft tumor model. |
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| DC9973 | Osilodrostat phosphate Featured | Osilodrostat (LCI699) phosphate is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat phosphate is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat phosphate inhibits aldosterone and corticosterone synthesis. Osilodrostat phosphate has blood pressure lowering ability. Osilodrostat phosphate can be used for research of Cushing syndrome (CS). |
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| DC60687 | DYR530 Featured | DYR530 is a high affinity DYRK1A inhibitor with Kd of 0.91 nM. |
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| DC60688 | Gibberellin A3 methyl ester Featured |
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| DC60690 | Gibberellin A4 Featured | Gibberellin A4 is a natural compound that can be isolated from Sphaceloma manihoticola. Gibberellin A4 is a causal agent of cassava superelongation disease. |
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| DC60689 | Gibberellin A5 Featured | Gibberellin A5 is a plant hormone that promotes floral development. |
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| DC60691 | Gibberellin A12 Featured |
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| DC67084 | gibberellin A12 aldehyde Featured |
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| DC67085 | Gibberellin A19 Featured |
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| DC67086 | GIBBERELLIN A20 Featured |
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| DC67087 | 2β,3β,4aα-Trihydroxy-1β-methyl-8-methylenegibbane-1α,10β-dicarboxylic acid 1,4a-lactone Featured |
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| DC67088 | Gibberellin 44 Featured |
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| DC67089 | GIBBERELLIN A51 Featured |
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| DC67090 | GIBBERELLIN A53 Featured |
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| A121 | Ocrelizumab Featured |
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| A115 | Casirivimab Biosimilar Featured | Casirivimab (REGN10933) is a human monoclonal antibody that targets the SARS-CoV-2 virus, which causes COVID-19. Casirivimab is ineffective against COVID-19 variants. Casirivimab can be used in combination with Imdevimab (HY-P99342), which alters the lung response of K18-hACE2 mice to the SARS-CoV-2 δ variant, effectively reducing viral load and improving symptoms. |
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| A108 | L19-TNF Biosimilar(Anti-Fibronectin Reference Antibody) Featured |
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| A120 | Imdevimab Featured | Imdevimab (REGN10987) is a human monoclonal antibody to target SARS-CoV-2 virus, which causes COVID-19. Imdevimab lacks efficacy against COVID-19 variants. Imdevimab can be used in combination with Casirivimab (HY-P99341), it reduces viral load and improves diseases. |
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