| DC4103 |
Dabrafenib Mesylate
Featured
|
Dabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. |
|
| DC7182 |
Dacinostat (NVP-LAQ824, LAQ824)
Featured
|
Dacinostat (NVP-LAQ824, LAQ824) is a highly potent HDAC inhibitor with IC50 of 32 nM. |
|
| DC7394 |
Daclatasvir dihydrochloride (BMS-790052)
Featured
|
Daclatasvir (BMS-790052) is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture. |
|
| DC4197 |
Actinomycin D
Featured
|
Dactinomycin (also known generically as Actinomycin D ) is the most significant member of actinomycines, which are a class of polypeptide antibiotics isolated from soil bacteria of the genus Streptomyces. |
|
| DC20353 |
Dafadine A
Featured
|
Dafadine A is the first reported small-molecule DAF-9 cytochrome P450 inhibitor that robustly induces dauer formation in in the nematode Caenorhabditis elegans. |
|
| DC21469 |
Dagrocorat |
Dagrocorat (PF 00251802) is a potent, selective high-affinity dissociated agonist of the glucocorticoid receptor.. |
|
| DC23077 |
Daidzin
Featured
|
Daidzin is a potent, selective aldehyde dehydrogenase 2 (ALDH2,IC50 = 80 nM) inhibitor, which has antiallergic anti-oxidant, anti-carcinogenic, antithrombotic,and anti-atherosclerotic activities |
|
| DCAPI1493 |
Dalbavacin
Featured
|
Dalbavancin, a semisynthetic lipoglycopeptide being developed for the treatment of skin and skin structure infections (SSSIs), has a half-life of 5 to 7 days in humans and offers promise for a convenient weekly dosing regimen. |
|
| DC3163 |
Dalcetrapib (JTT-705)
Featured
|
Dalcetrapib (JTT-705) is a rhCETP inhibitor with IC50 of 0.2 μM. |
|
| DC22810 |
Damnacanthal |
Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase with IC50 of 17 nM for inhibition of p56lck autophosphorylation. |
|
| DC21881 |
Danicamtiv (MYK-491)
Featured
|
Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency. |
|
| DC11082 |
Danicopan (ACH-4471)
Featured
|
Danicopan (ACH-4471, ACH-0144471) is a highly potent, orally active Factor D inhibitor with Kd of 0.54 nM, inhibits the proteolytic activity of purified Factor D against substrate Factor B in complex with C3b, blocking production of Bb fragment IC50 of 15 nM. |
|
| DC9689 |
Danirixin (GSK1325756)
Featured
|
Danirixin(GSK1325756) is a selective CXCR2 antagonist. |
|
| DCAPI1028 |
Danofloxacin Mesylate |
Danofloxacin Mesylate |
|
| DC8238 |
Danoprevir
Featured
|
Danoprevir is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM, inhibition effect for HCV genotypes 1A/1B/4/5/6 is ~10-fold higher than 2B/3A. |
|
| DC12338 |
Dansylamide |
Dansyl amide is a fluorescent dye that is used in biochemistry and chemistry to label substances with the fluorescent dansyl group. |
|
| DC8665 |
Dantrolene sodium hemiheptahydrate |
Dantrolene sodium hemiheptahydrate is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. Dantrolene sodium hemiheptahydrate is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ fro |
|
| DC9116 |
Dantrolene sodium |
Dantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Dantrolene sodium is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. |
|
| DC4125 |
PHA-739358 (danusertib)
Featured
|
Danusertib (PHA-739358) is an Aurora inhibitor for Aurora A/B/C, Bcr-Abl, c-RET and FGFR with IC50 of 13 nM/79 nM/61 nM, 25 nM, 31 nM and 47 nM, respectively. |
|
| DC6904 |
DAPAGLIFLOZIN
Featured
|
Dapagliflozin, also known as BMS-512148, is a drug used to treat type 2 diabetes approved in 2012 by FDA. Dapagliflozin inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2) which are responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter mechanism causes blood glucose to be eliminated through the urine. In clinical trials, dapagliflozin lowered HbA1c by 0.6 versus placebo percentage points when added to metformin. |
|
| DC20170 |
Dapagliflozin propanediol monohydrate
Featured
|
Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors. |
|
| DC20941 |
DAPH-1
Featured
|
DAPH-1 (CGP 52411) is a small molecule that directly inhibits prion protein Sup35 prionogenesis with IC50 of 0.58 uM, inhibits and reverses the formation of Aβ42 fibers and reduces their toxicity to neurons in culture. |
|
| DC20354 |
DAPH-12 |
DAPH-12 is a small molecule that directly inhibits and reverses prion protein Sup35 prionogenesis (IC50=0.18 uM). |
|
| DC7395 |
Dapivirine
Featured
|
Dapivirine(TMC 120, TMC 120 R147681) is a NNRTI for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. |
|
| DC9630 |
Dapoxetine (hydrochloride)
Featured
|
Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor(SSRI).
|
|
| DC8188 |
Daprodustat
Featured
|
Daprodustat(GSK1278863) isa HIF-prolyl hydroxylase inhibitor. |
|
| DC10259 |
Dapson |
Dapsone, also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. |
|
| DC7396 |
DAPT
Featured
|
DAPT(GSI-IX) is an inhibitor of γ-secretase; DAPT causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma. |
|
| DC1050 |
Daptomycin
Featured
|
Daptomycin is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. |
|
| DC7397 |
Darapladib
Featured
|
Darapladib is a selective and orally active inhibitor of Lp-PLA2 (IC50= 270 pM) |
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