| DC12172 |
L-JNKI-1 |
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK. |
|
| DC21234 |
LKY-047 |
LKY-047 is a decursin derivative that potently and selectively inhibits CYP2J2, competitively inhibits CYP2J2-mediated astemizole O-demethylase and terfenadine hydroxylase activity with Ki of 0.96 and 2.61 uM, respectively. |
|
| DC21235 |
LLL3 |
LLL3 is a structural analogue of STA-21 that acts as a novel STAT3 inhibitor, inhibits STAT3-dependent transcriptional and DNA binding activities. |
|
| DC20438 |
LLP2A |
LLP2A is a high-affinity, selective peptidomimetic ligand of α4β1 integrin with IC50 of 2 pM. |
|
| DC21237 |
LLS2 |
LLS2 is a novel potent Galectin-1 (Gal1) inhibitor that decreases membrane-associated H-Ras and K-Ras and contributed to the suppression of pErk pathway. |
|
| DC21238 |
LLS30 |
LLS30 is a potent, allosteric Galectin-1 (Gal-1) inhibitor, inhibits AR negative cells PC3, DU145, and AR positive cells, 22RV1 and CWR-R1 cells with IC50 of 10.4 μM, 5.3 μM, 3.3 μM and 5.9 μM, respectively. |
|
| DC21239 |
LLY-2707 |
LLY-2707 (LLY 2707, LLY2707) is a novel potent, selective, nonsteroidal glucocorticoid receptor antagonist with Ki of 2.13 nM. |
|
| DC21240 |
LLY-283
Featured
|
LLY-283 (LLY283) is a potent, selective inhibitor of arginine methyltransferase 5 (PRMT5) with IC50 of 22 nM. |
|
| DC7856 |
LLY-507
Featured
|
LLY-507 is a chemical probe for SMYD2 (a protein lysine methyltransferase). |
|
| DC10758 |
LM22B-10
Featured
|
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo. |
|
| DC23127 |
LMD-009 |
LMD-009 (LMD 009, LMD009) is a potent, selective, nonpeptide CCR8 agonist that stimulates CCR8-mediated chemotaxis, inositol phosphate accumulation and calcium release with EC50 of 11-87 nM. |
|
| DC11148 |
LMD-A |
LMD-A (CCR8 antagonist LMD-A) is a highly potent, small molecule antagonist of chemokine receptor CCR8 with EC50 of 2.5 nM. |
|
| DC10892 |
LMI070 (NVS-SM1)
Featured
|
LMI070 (NVS-SM1) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. |
|
| DC4241 |
LMK-235
Featured
|
LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor (IC50 values are 4.22, 11.9, 55.7, 320, 852, 881, and 1278 nM for HDAC 5, 4, 6, 1, 11, 2, and 8, respectively). |
|
| DC20259 |
LML134
Featured
|
LML134 (compound 18b) is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders[1]. |
|
| DC20275 |
LMP-744 hydrochloride
Featured
|
LMP744(Mj-III-65,NSC-706744) is a DNA intercalator and topoisomerase inhibitor with antitumor activity. |
|
| DC10836 |
LMPTP inhibitor 23
Featured
|
LMPTP inhibitor 1 is a potent molecule for diabetes which can increase liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes by inhibiting the IR phosphatase LMPTP. |
|
| DC12602 |
LMT-28
Featured
|
LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130. |
|
| DC21247 |
LN-1-255 |
LN-1-255 is a 6-alkylidene-2'-substituted penicillin sulfone that acts as an effective beta-lactamase inhibitor. |
|
| DCAPI1208 |
L-NAME HCl |
L-NAME is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, respectively. |
|
| DC25003 |
LOC14
Featured
|
LOC-14 is a small molecule reversible Protein disulfide isomerase (PDI) inhibitor with Kd of 62 nM. |
|
| DC10188 |
Lodoxamide
Featured
|
Lodoxamide is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis. |
|
| DC10694 |
Loflucarban
Featured
|
Loflucarban is an antiinfective drug |
|
| DC12324 |
Loganetin |
Loganetin is a non-toxic natural product that may be applied in the antibacterial drug development for treating multidrug-resistant Gram negative infections. |
|
| DC12142 |
LOM612 |
LOM612 is a potent activator of FOXO nuclear translocation, with an EC50 value of 1.5 μM in cells. |
|
| DCAPI1400 |
Lomefloxacin HCl (Maxaquin) |
Lomefloxacin HCl (Maxaquin) |
|
| DC7188 |
Lomeguatrib(PaTrin-2)
Featured
|
Lomeguatrib (PaTrin-2) is a modified guanine base, which can repress the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) with an IC50 value of 6 nM. |
|
| DC9177 |
Lomerizine hydrochloride |
Lomerizine dihydrochloride is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine. |
|
| DC7778 |
Lometrexol(LY 264618)
Featured
|
Lometrexol is a tight-binding antifolate inhibitor of the purine de novo enzyme glycinamide ribonucleotide formyltransferase (GARFT), was the first GARFT inhibitor to be investigated clinically. |
|
| DC7900 |
AEGR-733(Lomitapide)
Featured
|
Lomitapide (AEGR-733) is a novel proprietary MTP-inhibitor. |
|
