| DC23792 |
MAL3-101 |
MAL3-101 is a Hsc70 modulator that inhibits Hsp70 ATPase activity, exhibits antiproliferative activity in breast cancer cells SK-BR-3 with IC50 of 27 uM. |
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| DC22143 |
MALAT1-IN-1
Featured
|
MALAT1 inhibitor 5 (Malat1 inhibitor 5) is a selective small molecule targeting of Metastasis-associated lung adenocarcinoma transcript 1 (Malat1/MALAT1 mouse/human), a highly conserved long non-coding RNA; does not affect Neat1 lncRNA levels. |
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| DC12536 |
Malic Enzyme inhibitor ME1
Featured
|
Malic Enzyme inhibitor ME1 (ME1) is a small molecule inhibitor of Malic Enzyme (ME1) with IC50 of 0.15 uM, suppresses growth of human CRC cells in vitro, with little effect on normal rat intestinal epithelial cells.. |
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| DCAPI1277 |
Malotilate |
Malotilate |
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| DC11066 |
MALT1 paracaspase inhibitor 3 |
MALT1 paracaspase inhibitor 3 is a potent, specific, covalent inhibitor of MALT1 paracaspase with Ki of 10 nM, exhibits 10-and 100-fold improved potency in vitro and in vivo compared with Z-VRPR-fmk. |
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| DC20141 |
Maltitol
Featured
|
Maltitol is a sugar alcohol used as a sugar substitute. It has 75-90% of the sweetness of sucrose (table sugar) and nearly identical properties. Maltitol may also be used as a plasticizer in gelatin capsules, as an emollient, and as a humectant. |
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| DC12138 |
Maltohexaose (Amylohexaose) |
Maltohexaose is a natural saccharide, and can be produced from amylose, amylopectin and whole starch. |
|
| DC12157 |
Maltopentaose (Maltopentose) |
Maltopentaose is the shortest chain oligosaccharide that can be classified as maltodextrin and is also used in a study to investigate glycation and phosphorylation of α-lactalbumin. |
|
| DC9190 |
Manidipine Dihydrochlorid |
Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. |
|
| DC11315 |
Manidipine(CV-4093) |
Manidipine is a dihydropyridine L- and T-type calcium channel blocker. |
|
| DC23814 |
MAP4K4-IN-17
Featured
|
MAP4K4-IN-17 is a potent and highly selective MAP4K4 inhibitor with IC50 of 14.9 nM, showes improved overall drug-like properties compared to PF-06260933. |
|
| DC21916 |
MAP4K4-IN-37 |
MAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM. |
|
| DC20442 |
MAP4K4-IN-44 |
MAP4K4-IN-44 is a potent, moderately selective small molecule MAP4K4 inhibitor with IC50 of 5 nM in LC3K assay, demonstrates favorable in vivo bioavailability in mouse.. |
|
| DC21857 |
Mapracorat |
Mapracorat (ZK 245186) is a potent, selective and non-steroid glucocorticoid receptor (GR) agonist with binding Ki of 1.9 nM. |
|
| DC4217 |
Maraviroc
Featured
|
Maraviroc (Selzentry, UK-427857, Celsentri) is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM, respectively. |
|
| DC21269 |
Marbostat-100 |
Marbostat-100 is a potent, selective HDAC6 inhibitor with Ki of 0.7 nM, displays >200-fold selectivity over HDAC1-5, and HDAC7-10. |
|
| DC8909 |
Maribavir
Featured
|
Maribavir(GW257406X; BW1263W94; 1263W94) inhibits HCMV replication is by inhibition of an HCMV encoded protein kinase enzyme called UL97 or pUL97. |
|
| DC8031 |
Marimastat |
Marimastat is a broad spectrum MMP inhibitor and selective TACE inhibitor |
|
| DC10639 |
Marinopyrrole A (Maritoclax) |
Marinopyrrole A (Maritoclax) is a selective Mcl-1 antagonist. It binds to Mcl-1, but not Bcl-XL, and targets Mcl-1 for proteasomal degradation. Maritoclax disrupts the interaction between Bim and Mcl-1 with an IC50 of 10.1 μM. |
|
| DC22297 |
Marmesin
Featured
|
Marmesin is a coumarin originally isolated from the mature bark of A. marmelos. |
|
| DC20883 |
Maropitant citrate |
Maropitant citrate (Cerenia) is a selective neurokinin 1 receptor (NK1) antagonist for prevention of vomiting due to motion sickness in dogs.. |
|
| DC9519 |
Maropitant |
Maropitant is a neurokinin (NK1) receptor antagonist. |
|
| DC20443 |
MARPIN |
MARPIN is a novel ATR-Chk1 pathway inhibitor that inhibits hydroxyurea (HU)-induced phosphorylation of Ser345 on Chk1 with IC50 of 7.7 uM. |
|
| DC7460 |
Masitinib
Featured
|
Masitinib is a broad coronavirus 3CL inhibitor that effectively blocks replication of SARS-CoV-2. Science 20 Jul 2021: eabg5827 DOI: 10.1126/science.abg5827 |
|
| DC11524 |
Mavacamten（MYK-461）
Featured
|
Mavacamten（MYK-461）is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain. |
|
| DC8378 |
Mavatrep(JNJ-39439335)
Featured
|
Mavatrep is an orally bioavailable TRPV1 antagonist (Ki=6.5 nM), exhibits minimal effect on the enzymatic activity (IC50 > 25 μM) of CYP isoforms 3A4, 1A2, and 2D6. |
|
| DC7681 |
Mavoglurant (AFQ 056)
Featured
|
Mavoglurant (AFQ056) is an experimental drug candidate for the treatment of fragile X syndrome.It exerts its effect as an antagonist of the metabotropic glutamate receptor 5 (mGLU5). |
|
| DC11285 |
MAZ51
Featured
|
MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 µM) without blocking VEGFC-mediated stimulation of VEGFR2. |
|
| DC11236 |
MB-07811 (VK-2809)
Featured
|
MB-07811 (VK-2809) is an orally bioavailable, liver-targeted prodrug of MB07344, which is a thyroid hormone receptor-beta agonist (TRβ) agonist, efficiently converted to MB07344 by liver microsomes in vivo. |
|
| DC10958 |
MB710 |
MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro.. |
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