| DC10957 |
MB725
Featured
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MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM). |
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| DC10062 |
MBP146-78
Featured
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MBP146-78 inhibits the growth of Eimeria spp. both in vitro and in vivo. |
|
| DC12094 |
MBQ-167 |
MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively. |
|
| DC7193 |
MBX-2982
Featured
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MBX-2982 is a selective, orally-available GPR119 agonist for the treatment of type 2 tiabetes. |
|
| DC10872 |
MBX-4132
Featured
|
MBX-4132 a trans translation inhibitor by binding to the bacterial ribosome. |
|
| DC5128 |
MC1568
Featured
|
MC1568 is a class II (IIa) HDAC inhibitor selective for HDAC4 and HDAC6 |
|
| DC21270 |
MC-1575 |
MC-1575 is a potent and selective class IIa HDAC inhibitor with IC50 of 440 nM for maize HD1-A, displays >70-fold selectivity over HD1-B. |
|
| DC12527 |
MC180295
Featured
|
MC180295 (MC-180295, MC 180295) is a novel potent, highly selective CDK9 inhibitor with IC50 of 5 nM, displays >22-fold selectivity over other CDKs. |
|
| DC23370 |
MC2884 |
MC2884 is a novel hybrid, dual HAT/EZH2 inhibitor with IC50 of 3.27, 8.35 and 4.56 uM for CBP, KAT5 and p300, respectively. |
|
| DC10940 |
MC3343
Featured
|
MC3343 (MC-3343) is a novel potent, non-nucleoside DNA methyltransferase (DNMT) inhibitor with IC50 of 5.7 and 1.7 uM for DNMT1 and DNMT3a. |
|
| DC11358 |
CPP32 Fluorogenic Substrate III |
Mca-DEVDAPK(Dnp)-OH is a substrate for caspase-3. |
|
| DC11338 |
MMP-2/MMP-7 Fluorogenic Substrate Control
Featured
|
Mca-PL is a fluorogenic peptide that has been used as a building block in the synthesis of Mca-PLGL-Dpa-AR-NH2, a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7. |
|
| DC8550 |
MCB-613
Featured
|
MCB-613 is a novel and potent stimulator of p160 steroid receptor coactivators (SRCs). It is a Pan-SRCs stimulator. |
|
| DC23706 |
Netoglitazone(MCC 555)
Featured
|
Netoglitazone, also known as isaglitazone and MCC-555, is an agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic activity. Netoglitazone exerts both peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonist activity. Netoglitazone decreases bone formation and increases marrow adipocyte formation in vivo.MCC 555 (Isaglitazone. |
|
| DC26109 |
MCL0129 tetrahydrochloride
Featured
|
MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3. |
|
| DC26085 |
MCL0129 |
MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3. |
|
| DC22643 |
Mcl1-IN-2 |
Mcl1-IN-2 is an Mcl-1 inhibitor without a reported IC50 value.. |
|
| DC20444 |
Mcl-1-Puma inhibitor 8 |
Mcl-1-Puma inhibitor 8 is a small-molecule dual-acting compound that targets the apoptotic Mcl-1-PUMA interface with Ki of 0.3 uM (Mcl-1, FPA), reduces multiple cancer cells and inhibits PUMA-mediated apoptosis. |
|
| DC10353 |
MCOPPB triHydrochloride |
MCOPPB 3Hcl is a nociceptin receptor agonist with pKi of 10.07; weaker activity at other opioid receptors. |
|
| DC23820 |
MCP110
Featured
|
MCP110 is a potent Ras/Raf-1 interaction inhibitor. |
|
| DC23644 |
MCT1-IN-4a |
MCT1-IN-4a is a potent, selective monocarboxylate transporter 1 (MCT1) inhibitor with IC50 of 90 nM. |
|
| DC10120 |
MC-Val-Cit-PAB
Featured
|
MC-Val-Cit-PAB, also known as MC-Val-Cit-PAB-OH, is a cathepsin cleavable ADC peptide linker. MC-Val-Cit-PAB is useful for making ADC conjugate (antibody-drug conjugate). FDA approved drugs such as brentuximab vedotin used this linker. |
|
| DC8461 |
Mc-Val-Cit-PABC-PNP（VCMMAE linker）
Featured
|
Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker. |
|
| DC7841 |
MDA 19 |
MDA 19 is a selective human CB2 receptor agonist with Ki of 43.3 nM. |
|
| DC12581 |
MDI-2268
Featured
|
MDI-2268 (MDI2268) is a small-molecule, in vivo-active inhibitor of plasminogen activator inhibitor type-1 (PAI-1), demonstrates excellent pharmacokinetics, potent activity against vitronectin-bound PAI-1 in vivo, and efficacy in murine model of venous thrombosis. |
|
| DC7743 |
Mdivi-1
Featured
|
Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. |
|
| DC10569 |
MDK1088（T.cruzi Inhibitor）
Featured
|
MDK-1088, also known as T.cruzi Inhibitor, is a Trypanosoma cruzi inhibitor. MDK-1088 has CAS#1350920-22-7 . The last 4 digit f CAS# was used in its name. |
|
| DC10573 |
MDK34597 (PI3K inhibitor)
Featured
|
MDK34597 is a PI3K inhibitor.MDK34597 is an analog of PI-103 and acts as a dual PI3K/mTOR Inhibitor. |
|
| DC10572 |
MDK35833（Oct3/4-inducer-1）
Featured
|
MDK35833, also known as Oct3/4-inducer-1, is a potent Oct3/4-inducer. |
|
| DC9297 |
MDK-5220(Orexin-2 receptor agonist)
Featured
|
MDK-5220(Orexin-2 receptor agonist) is the first selective nonpeptidic orexin 2 receptor (OX2R) agonist (OX2R EC50 = 0.023 μM, Emax = 98%; OX1R EC50 = 1.616 μM, Emax = 100%) |
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