| DC23113 |
Mirk-IN-1
Featured
|
Mirk-IN-1 is a potent, specific inhibitor of Dyrk1B (Mirk kianse) and Dyrk1A with IC50 of 68 nM and 22 nM respectively, shows SW620 cell IC50 of 1.9 uM. |
|
| DC10013 |
Mirogabalin
Featured
|
Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium-channel complexes in the CNS. |
|
| DC10532 |
Mirogabalin besylate
Featured
|
Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium-channel complexes in the CNS. |
|
| DCAPI1370 |
Mirtazapine (Remeron, Avanza) |
Mirtazapine (Remeron, Avanza) |
|
| DC10568 |
Mitapivat
Featured
|
Mitapivat is an activator of pyruvate kinase isoenzyme M2 (PKM2), |
|
| DC20452 |
MitoBloCK 1 |
MitoBloCK 1 is a small molecule inhibitor that blocks the import of substrates that use the TIM22 import pathway, but not TIM23 or the Mia40/Erv1 translocation pathways. |
|
| DC12625 |
MitoBloCK-10
Featured
|
MitoBloCK-10 (MB-10) is a potential attenuator of protein import into mitochondria via targeting Tim44, inhibits the import of substrates that use the TIM23 import pathway. |
|
| DC12626 |
MitoBloCK-11
Featured
|
MitoBloCK-11 (MB-11) is a s mall molecule inhibitor of mitochondrial protein import possibly acts through transport protein Seo1, but not Tom70 or Tom20; inhibits precursor proteins that contain hydrophobic segments, confers growth in media lacking uracil in a specific manner and affects zebrafish development. |
|
| DC8935 |
Mitomycin C
Featured
|
Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells. |
|
| DCAPI1234 |
Mitotane (Lysodren) |
Mitotane (Lysodren) |
|
| DC12364 |
Mito-TEMPO
Featured
|
Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic with superoxide and alkyl radical scavenging properties. |
|
| DCAPI1315 |
Mitoxantrone HCl |
Mitoxantrone HCl |
|
| DC21279 |
MIV-247 |
MIV-247 (MIV247) is a potent, selective, orally active inhibitor of cathepsin S with Ki of 2.1 nM (human cathepsin S). |
|
| DC22150 |
MIV-711 |
MIV-711 (MIV711, MV076159) is a potent, selective cathepsin K inhibitor with Ki of 0.98 nM, displays >1300-fold versus the other human cathepsins. |
|
| DC9836 |
Mivebresib(ABBV-075）
Featured
|
Mivebresib is a novel BET family inhibitor, disrupts critical transcription programs that drive prostate cancer growth to induce potent anti-tumor activity in vitro and in vivo. |
|
| DC20978 |
Mizagliflozin
Featured
|
Mizagliflozin (DSP-3235, KGA-3235, GSK-1614235) is a potent, selective, orally active SGLT1 inhibitor with Ki of 27 nM, displays >350-fold selectivity over SGLT2. |
|
| DC9468 |
Mizolastine |
Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. |
|
| DC9011 |
Mizoribine
Featured
|
Mizoribine(NSC 289637; HE 69; β-Bredinin) is an immunosuppressive agents (IC50=100 uM) that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH. |
|
| DC21282 |
MJN110
Featured
|
MJN110 (MJN-110) is a potent, selective, and orally active MAGL inhibitor with IC50 of 2.1 nM (2-AG hydrolysis). |
|
| DC21283 |
MJN-228 |
MJN-228 is a selective ligand for the lipid-binding protein nucleobindin 1 (NUCB1) with IC50 of 3.3 uM (blocks AEA-DA probe labeling of NUCB1). |
|
| DC1009 |
Laropiprant
Featured
|
MK 0524 is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 µM for the DP1 and DP2 receptors, respectively. |
|
| DC23419 |
MK-0249 |
MK-0249 is a novel potent, selective histamine H3 inverse agonist for the treatment of cognitive impairment with schizophrenia.. |
|
| DC23658 |
MK-0343 |
MK-0343 (MRK-409) is a potent, α2/3 subtype selective, partial GABAA receptor agonist, shows greater agonist efficacy at the α3 over α1 subtypes. |
|
| DC9456 |
MK-0354 |
MK-0354 is a partial agonist of GPR109a receptor, for hGPR109a/ mGPR109a with EC50 of 1.65/1.08 μM, showed no activation of GPR109b.
|
|
| DC21289 |
MK-0429 |
MK-0429 is a potent, selective, orally-active nonpeptide αvβ3 integrin inhibitor with IC50 of 0.08 nM in SPAV3 assay. |
|
| DC21290 |
MK-0448 |
MK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM. |
|
| DC10045 |
MK-0557
Featured
|
MK-0557 is a highly selective, orally administered neuropeptide NPY5R antagonist, could limit weight regain after very-low-calorie diet (VLCD)-induced weight loss. |
|
| DC23665 |
MK-0674 |
MK-0674 is a potent, selective, reversible and orally active cathepsin K inhibitor with IC50 of 1 nM. |
|
| DC23343 |
MK-0731 |
MK-0731 is a potent, selective kinesin spindle protein (KSP) inhibitor with IC50 of 2.2 nM, cell EC50 of 5.3 nM. |
|
| DC3167 |
MK0812 |
MK-0812 is chemokine receptor CCR-2 antagonist |
|
