| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC25080 | 6-Maleimidohexanoic acid N-hydroxysuccinimide ester | A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. |
|
| DC11564 | CDK9-PROTAC | A heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9. |
|
| DC12012 | PD 404182 Featured | PD 404182 is a high affinity inhibitor of KDO 8-P synthase (Ki = 26 nM). Also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). Exhibits antiangiogenic and antiviral activity in vitro. Putative antibiotic against gram-negative bacteria. |
|
| DC22860 | Saframycin A | A heterocyclic quinone antibiotic that inhibits RNA synthesis in vivo and in vitro. |
|
| DC23757 | MLS-000532223 | A high affinity, selective inhibitor of Rho family GTPases with EC50 of 16-120 uM. |
|
| DC23268 | MIV 150 | A high-affinity, allosteric HIV-1 and HIV-2 reverse transcriptase inhibitor (NNRTI) with EC50 of 1 nM. |
|
| DC21592 | ML165 | A high-affinity, selective platelet integrin αIIbβ3 receptor antagonist with IC50 of 96 nM. |
|
| DC22429 | 4-BBPB Featured | A highly potent agonist of σ1 receptor with Ki of 0.8 nM. |
|
| DC22523 | 3-Deazaneplanocin A hydrochloride | A highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2. |
|
| DC23476 | MRS-2500 | A highly potent and selective antagonist of the platelet P2Y1 receptor with Ki of 0.78 nM. |
|
| DC23477 | MRS-2500 tetraammonium | A highly potent and selective antagonist of the platelet P2Y1 receptor with Ki of 0.78 nM. |
|
| DC21604 | SA-57 | A highly potent and selective dual FAAH/MAGL inhibitor with IC50 of 1-3 nM against FAAH, inhibits mouse (IC50=410 nM) and human (IC50=1.4 uM) MAGL. |
|
| DC11765 | GRK2-IN-115h hydrochloride | A highly potent and selective GRK2 inhibitor with IC50 of 18 nM. |
|
| DC25060 | XDM-CBP | A highly potent and selective inhibitor of CBP/p300 bromodomain with Kd of 0.23/0.47 uM respectively, with high selectivity over all other BD families, including the BET family. |
|
| DC21649 | Volixibat potassium | A highly potent and selective inhibitor of the apical sodium-dependent bile acid transporter (ASBT) in development for the treatment of nonalcoholic steatohepatitis (NASH).. |
|
| DC21648 | Volixibat | A highly potent and selective inhibitor of the apical sodium-dependent bile acid transporter (ASBT) in development for the treatment of nonalcoholic steatohepatitis (NASH).. |
|
| DC9843 | AKR1C3 Inhibitor 5f Featured | A highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3. |
|
| DC22436 | JDTic | A highly potent and selective kappa Opioid receptor (KOR) antagonist with Ki of 0.3 nM. |
|
| DC22674 | TCV-309 | A highly potent and selective platelet activating factor (PAF) antagonist. |
|
| DC22560 | TCV-309 chloride | A highly potent and selective platelet activating factor (PAF) antagonist. |
|
| DC11779 | TNKS-IN-41 | A highly potent and selective tankyrase inhibitor with pIC50 of 8.5 and 8.1 for TNKS1 and TNKS2, respectively. |
|
| DC24134 | GCGR-IN-1 | A highly potent glucagon receptor antagonist.. |
|
| DC24083 | 4-IBP Featured | A highly potent sigma receptor agonist with Ki of 1.7 nM and 25.2 nM for σ1 and σ2, respectively. |
|
| DC21813 | MT-7716 | A highly potent, brain-penetrating ORL1 receptor (NOP receptor) agonist with Ki of 0.76 and 0.50 nM for rat and human ORL1 receptors, respectively. |
|
| DC21258 | LY 2812223 | A highly potent, functionally selective mGlu2 receptor agonist with EC50 of 13.6 nM in GTPγS functional binding assay. |
|
| DC23409 | AZD 8683 | A highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4. |
|
| DC22822 | Saxagliptin hydrate | A highly potent, long-acting, orally active DPP4 inhibitor with Ki of 0.6 nM. |
|
| DC11861 | TAK-441 | A highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays. |
|
| DC23848 | YM-359445 | A highly potent, orally active VEGFR-2 inhibitor with IC50 of 8.5 nM, without activity against PKA, PKCα, PDK-1 and JNK3 (IC50>1 uM). |
|
| DC24063 | Cediranib maleate Featured | A highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively. |
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