| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC20911 | Omuralide Featured | A potent 20S proteasome inhibitor with IC50 of 49 nM (inhibition of proteasomal chymotrypsin-like proteolytic activity).. |
|
| DC21726 | TAK-802 | A potent acetylcholinesterase (AChE) inhibitor with IC50 of 1.3 nM. |
|
| DC21727 | TAK-802 hydrochloride | A potent acetylcholinesterase (AChE) inhibitor with IC50 of 1.3 nM. |
|
| DC11614 | ENT1-IN-39 | A potent adenosine transport activity of ENT-1 with IC50 of 26.9 nM. |
|
| DC20957 | TCDD | A potent AHR (aryl hydrocarbon receptor) agonist that induces degradation of AhR by the ubiquitin-proteasome pathway. |
|
| DC23997 | Aleglitazar | A potent and balanced dual PPARα/γ agonist (EC50= 50/21 nM). |
|
| DC22969 | BC-54 | A potent and biologically-active PDE4/7 inhibitor with IC50 of 50-100 nM for PDE4A/B/D, and 140 nM for both PDE7A/B. |
|
| DC20804 | BMS-204352 | A potent and effective calcium-sensitive opener of maxi-K potassium channels (maxi-K) with EC50 of 392 nM at -48.4 mV in HEK293 isolated outside-out membrane patches. |
|
| DC22960 | ICA-105574 Featured | A potent and efficacious hERG channel activator steeply potentiates current amplitudes more than 10-fold with EC50 of 0.5 uM. |
|
| DC11715 | PV-1115 | A potent and highly selective Chk2 inhibitor with IC50 of 0.14 nM. |
|
| DC11974 | L 741742 hydrochloride | A potent and highly selective D4 dopamine receptor antagonist with Ki of 3.5 nM, >200-fold selectivity over D2 and D3 receptors. |
|
| DC21158 | JAK3-IN-2 Featured | A potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM. |
|
| DC20835 | BRD-7880 | A potent and highly specific inhibitor of Aurora B and Aurora C with IC50 of 7 and 12 nM respectively, with less activity against Aurora A (IC50>2 uM). |
|
| DC22627 | Trametinib DMSO solvate Featured | A potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM. |
|
| DC22496 | W-54011 | A potent and orally active non-peptide C5a receptor (CD88. |
|
| DC11865 | DS-5272 | A potent and orally active p53-MDM2 interaction inhibitor with IC50 of 2.4 nM. |
|
| DC11743 | BMS-681 | A potent and orally bioavailable dual antagonist of CCR2 and CCR5 with binding IC50 of 0.7 nM and 2.4 nM, respectively. |
|
| DC22772 | ANI-7 | A potent and selective (up to 263-fold) inhibitor of breast cancer cells with GI50 of 0.5 uM (MCF-7), via activation the aryl hydrocarbon receptor (AhR) pathway. |
|
| DC22622 | WAY-100635 | A potent and selective 5-HT1A receptor antagonist. |
|
| DC21471 | PF-03246799 | A potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A. |
|
| DC22368 | Alosetron | A potent and selective 5-HT3 receptor antagonist has been shown to be beneficial in the treatment of irritable bowel syndrome.. |
|
| DC23952 | GR-79236 Featured | GR79236 is a highly potent and selective adenosine A1 receptor agonist (Ki = 3.1 nM) that has analgesic and anti-inflammatory actions in humans and animals. |
|
| DC20655 | AM-1221 | A potent and selective agonist for the cannabinoid receptor CB1 with Ki of 0.28 nM, 180-fold selectivity over CB2.. |
|
| DC22498 | A-443654 Featured | A potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1. |
|
| DC23832 | ALK5-IN-16i | A potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3. |
|
| DC22584 | Mavorixafor(AMD-070) Featured | A potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay. |
|
| DC22583 | AMD-070 hydrochloride(Mavorixafor) Featured | A potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay. |
|
| DC22376 | Pitolisant oxalate | A potent and selective antagonist of H3 receptor with Ki/EC50 of 0.16/1.5 nM. |
|
| DC22377 | Pitolisant | A potent and selective antagonist of H3 receptor with Ki/EC50 of 0.16/1.5 nM. |
|
| DC24108 | CCT241533 | A potent and selective ATP-competitive inhibitor of CHK2 K5777:N5777with IC50 of 3 nM. |
|
