| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC22978 | PF-04471141 hydrochloride | A potent and selective, CNS-penetrant PDE1 inhibitor with IC50 of 35 nM for PDE1B.. |
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| DC22802 | MK2-IN-28 | A potent and selective, non-ATP competitive, allosteric MAPKAPK2/3 (MK2/3) inhibitor with IC50 of 8 nM for MK2, hTNFα EC50 of 0.31 uM. |
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| DC20888 | Fadrozole | A potent and selective, orally bioavailable aromatase inhibitor with IC50 of 1.7 nM, 180 times more potent than aminoglutethimide. |
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| DC21004 | EXEL-8232 | A potent and selective, orally bioavailable JAK2 inhibitor with IC50 of 2 nM. |
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| DC23843 | BMS-935177 | A potent and selective, orally bioavailable, reversible BTK inhibitor with IC50 of 2.8 nM. |
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| DC22913 | WEB-2086 Featured | A potent and specific antagonist of platelet activating factor (PAF) receptor that inhibits PAF-induced human platelet and neutrophil aggregation in vitro with IC50 of 0.17 and 0.36 uM, respectively. |
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| DC23392 | RX-37 | A potent and specific BET bromodomain inhibitor with Ki of 3.2-24.7 nM for BD1 and BD2 domains of BRD2, BRD3, and BRD4. |
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| DC22375 | RS-102895 Featured | RS102895 is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1. |
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| DC22432 | CCX2553 | A potent and specific CCR6 antagonist. |
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| DC24199 | OSU-T315 (ILK-IN-1) Featured | OSU-T315 (ILK-IN-1) is a potent and specific integrin-linked kinase (ILK) inhibitor which inhibits PDK2 function in the AKT pathway activation |
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| DC22444 | Leptomycin B Featured | A potent and specific nuclear export inhibitor that binds to and inhibits CRM1 (XPO1). |
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| DC23495 | DBIBB | A potent and specific, nonlipid agonist of LPA2 receptor with EC50 of 100 nM, without activating or inhibiting LPA1/3/4/5 receptors. |
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| DC22771 | Proxalutamide Featured | Proxalutamide (GT-0918) is a nonsteroidal antiandrogen (NSAA) – specifically, a selective high-affinity silent antagonist of the androgen receptor (AR) for the potential treatment of COVID-19, prostate cancer, and breast cancer. |
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| DC25033 | EGA | A potent anthrax lethal toxin entry inhibitor with IC50 of 1.7 uM, inhibits endosomal trafficking pathways exploited by multiple toxins and viruses. |
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| DC21425 | NSC639829 | A potent anticancer agent that demonstrates potent antitumor activity in vitro against several cancer cell lines as well as in vivo against several tumor models, effectively inhibits in vitro tubulin polymerization. . |
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| DC11901 | Leflutrozole | A potent aromatase inhibitor for the treatment of hypogonadism.. |
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| DC22639 | RWJ-49815 | A potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM. |
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| DC23289 | BCL6 inhibitor 7 | A potent BCL6 protein-protein interaction inhibitor with Kd of 78 nM. |
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| DC23212 | DMCM hydrochloride | A potent benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity. |
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| DC11568 | HJB-97 | A potent BET bromodomian inhibitor with IC50 of 3-7 nM for BRD2/3/4 BD1 and BD2.. |
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| DC22443 | Paxilline Featured | A potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels that binds to the α-subunit of BKCa with Ki of 1.9 nM. |
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| DC21833 | DMP 543 Featured | A potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM. |
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| DC21621 | Ronacaleret hydrochloride | A potent calcium sensing receptor (CaSR) negative allosteric modulator with IC50 of 146 nM for hCaSR. |
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| DC21622 | Ronacaleret | A potent calcium sensing receptor (CaSR) negative allosteric modulator with IC50 of 146 nM for hCaSR. |
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| DC22641 | NWL-117 | A potent Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM. |
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| DC24000 | MK-0812 succinate | A potent CCR2 specific antagonist that blocks MCP-1 mediated response with an IC50 of 3.2 nM. |
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| DC23536 | AF-399 42016530 | A potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo. |
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| DC23535 | ST 016907 | A potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo.. |
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| DC22649 | NU-6102 | A potent CDK1 and CDK2 inhibitor with IC50 of 9.5 nM and 5.4 nM against CDK1/cyclinB and CDK2/cyclinA3 respectively. |
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| DC11625 | Divin | A potent chelator of iron that arrests late stages of cytokinesis by blocking the physical process of constriction in dividing cells. |
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