DCAPI1496 |
Ambrisentan
Featured
|
A nonpeptide endothelin ETA receptor antagonist. Antihypertensive. |
|
DC11919 |
Arimoclomol
Featured
|
A nontoxic heat shock protein (HSP) coinducer and potentiator of the heat shock response. |
|
DC11920 |
Arimoclomol maleate
Featured
|
A nontoxic, orally active heat shock protein (HSP) coinducer and potentiator of the heat shock response. |
|
DC11523 |
Landipirdine |
A novel 5-HT receptor antagonist for the treatment of Parkinson's disease.. |
|
DC11929 |
ME-344 |
A novel mitochondrial and mTOR inhibitor with potent anti-cancer activity, inhibits leukemia cell lines with IC50 of 70-260 nM. |
|
DC11910 |
IPL-576092 |
A novel orally active, anti-inflammatory compound that inhibits leukocyte infiltration and changes in lung function in response to allergen challenge. |
|
DC11811 |
SCY-078 |
A novel orally bioavailable fungal beta-1,3-D glucan synthetase inhibitor against Candida species C. glabrata (MIC 0.03 to 0.25 ug/ml), C. parapsilosis (MIC 0.06 to 0.25 ug/ml). |
|
DC11515 |
Azeloprazole |
A novel potent proton pump inhibitor that irreversibly inhibits H+,K+-ATPase activity with IC50 of 0.28 uM. |
|
DC11607 |
JTZ-951(Enarodustat)
Featured
|
A novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2. |
|
DC11608 |
JTZ-951 hydrochloride |
A novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2. |
|
DC11546 |
Azeloprazole sodium |
A novel potent, orally active proton pump inhibitor that irreversibly inhibits H+,K+-ATPase activity with IC50 of 0.28 uM. |
|
DC11854 |
IDX899 |
A novel potent, selective HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) with EC50 of 1, 1.3, 2.8 and 11 nM for WT, K103N, Y181C and K103N/Y181C, respectively. |
|
DC11536 |
Imigliptin dihydrochloride |
A novel potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM. |
|
DC11631 |
INCB040093 |
A novel potent, selective, orally available PI3Kδ inhibitor with IC50 of 31 nM. |
|
DC11547 |
LY-2562175
Featured
|
LY2562175 is a potent and selective FXR agonist, with an EC50 of 193 nM. |
|
DC11908 |
Ralaniten |
A novel small-molecule inhibitor of androgen receptor (AR) N-terminal domain inhibitor for the treatment of advanced prostate cancer. |
|
DC11909 |
Ralaniten acetate |
A novel small-molecule inhibitor of androgen receptor (AR) N-terminal domain inhibitor for the treatment of advanced prostate cancer. |
|
DC11825 |
MK-8876 |
A novel, broadly acting non-nucleoside inhibitor of HCV NS5B polymerase with IC50 of 3 nM and 2 nM for GT1b and GT2a, respectively. |
|
DC11799 |
G1T38 |
A novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 2 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively. |
|
DC11800 |
G1T38 dihydrochloride |
A novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 2 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively. |
|
DC22584 |
Mavorixafor(AMD-070)
Featured
|
A potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay. |
|
DC11674 |
PF-DcpSi |
A potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM. |
|
DC11772 |
AZD-4316 |
A potent respiratory syncytial virus (RSV) fusion inhibitor.. |
|
DC11647 |
JNJ-2408068
Featured
|
JNJ 2408068 is a potent RSV (respiratory syncytial virus) inhibitor. JNJ2408068 significantly inhibits replication of RSV A and B subtypes in the lungs of cotton rats without any evidence of toxicity. The minimum protective dose of JNJ 2408068 appears to be approximately 0.39 mg/kg[1]. |
|
DC11641 |
Cridanimod
Featured
|
A potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route. |
|
DC11533 |
PH-46A N-Methyl-D-Glucamine salt |
A potent, first-in-class, oral small-molecule agent for the treatment of inflammatory bowel diseases.. |
|
DC11532 |
PH-46A |
A potent, first-in-class, oral small-molecule agent for the treatment of inflammatory bowel diseases.. |
|
DC24010 |
Plpro-IN-6(PLpro inhibitor)
Featured
|
A potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 2.6 uM. |
|
DC11893 |
Firibastat |
A potent, orally active, centrally acting aminopeptidase inhibitor, the prodrug of the specific and selective aminopeptidase A inhibitor EC33. |
|
DC11518 |
Cavosonstat
Featured
|
Cavosonstat is a potent, orally bioavailable inhibitor of S-nitrosoglutathione reductase (GSNOR) and CFTR modulator. |
|