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1-Azakenpaullone

  Cat. No.:  DC5144   Featured
Chemical Structure
676596-65-9
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Field of application
1-Azakenpaullone is a potent and ATP-competitive GSK-3β (glycogen synthase kinase-3β) inhibitor (IC₅₀ = 18 nM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 676596-65-9
Chemical Name: 1-AZAKENPAULLONE
Synonyms: 1-AZAKENPAULLONE;1-Azakenpaullone (1-Akp);1-Azakenpaullone​;9-Bromo-7,12-dihydro-pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one;azakenpaullone;HMS3229B07;Kinome_3492;9-Bromo-7,12-dihydro-pyrido[3′,2′:2,3]azepino[4,5-b]indol-6(5H)-one
SMILES: CC1C=CC2=C(C3CC(=O)NC4=CC=CN=C4C=3N2)C=1
Formula: C16H13N3O
M.Wt: 263.293923139572
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: 1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β), with an IC50 value of 18 nM[1].
Target: GSK-3β:18 nM (IC50) CDK1/cyclin B:2 μM (IC50) CDK5/p25:4.2 μM (IC50)
References: [1]. Kunick C, et al. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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DC5144 1-Azakenpaullone 1-Azakenpaullone is a potent and ATP-competitive GSK-3β (glycogen synthase kinase-3β) inhibitor (IC₅₀ = 18 nM).
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