JHU-083|Glutamine antagonist|CAS 1998725-11-3

Cas No.:	1998725-11-3
Chemical Name:	ethyl (S)-2-((S)-2-amino-4-methylpentanamido)-6-diazo-5-oxohexanoate
Synonyms:	JHU083;JHU 083
SMILES:	C(OCC)(=O)[C@H](NC(=O)[C@H](N)CC(C)C)CCC(=O)C=[N+]=[N-]
Formula:	C₁₄H₂₄N₄O₄
M.Wt:	312.37
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Description:

JHU-083 inhibits increased glutaminase activity in isolated CD11b+ cells, but not other cells in the prefrontal cortex and hippocampus of mice subjected to CSDS. JHU-083 suppresses CSDS-induced upregulation of proinflammatory cytokines in CD11b+ cells. [1

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC8818	Acivicin	Acivicin is a glutamine analog that irreversibly inhibits glutamine-dependent amidotransferases involved in nucleotide and amino acid biosynthesis (Kis = 10 and 560 μM for anthranilate synthase and glutamate synthase, respectively).
DC26214	Caspase-9 Inhibitor III(Ac-LEHD-CMK)	#N/A
DC26213	YAP-TEAD Inhibitor 1 (Peptide 17)	#N/A
DC26139	2-(5-Chloro-1H-indol-2-yl)acetic acid	2-(5-Chloro-1H-indol-2-yl)acetic acid\|CAS 720000-48-6
DC26209	Papain Inhibitor	#N/A
DC11456	Chymotrypsin substrate（MeO-Suc-Arg-Pro-Tyr-pNA）	MeO-Suc-Arg-Pro-Tyr-pNA is a synthetic colorimetric peptide substrate displaying chymotrypsin-like specificity and is used in the measurement of Kallikreins. It is succinylated at N-terminus and has a nitroanilide tag at the C-terminus.
DC24032	PTP1B-IN-1	A 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for design of protein tyrosine phosphatase-1B (PTP1B) inhibitor.
DC11230	JHU-083	JHU-083 is a Glutamine antagonist, a DON prodrug.
DC8050	Akt Inhibitor IV	Akt Inhibitor IV is n Inhibitor of Akt protein kinase
DC9240	PS-47