Milademetan |CAS 1398568-47-2|DC Chemicals

Cas No.:	1398568-47-2
Chemical Name:	Milademetan
Synonyms:	Milademetan;DS-3032;L-erythro-Hexonamide, 2,6-anhydro-5-[[[(3'R,4'S,5'R)-6''-chloro-4'-(2-chloro-3-fluoro-4-pyridinyl)-1'',2''-dihydro-4,4-dimethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-[3H]indol]-5'-yl]carbonyl]amino]-3,4,5-trideoxy-;DS-3032B (Milademetan)
SMILES:	O=C1NC2=CC(Cl)=CC=C2[C@]21[C@@H](C1=CC=NC(Cl)=C1F)[C@H](C(=O)N[C@H]1CO[C@H](C(=O)N)CC1)NC12CCC(C)(C)CC1
Formula:	C₃₀H₃₄Cl₂FN₅O₄
M.Wt:	618.526468753815
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

DS-3032b is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity; binds to, and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53; restores p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC11726	Milademetan	Milademetan (DS-3032) is a specific and orally active MDM2 inhibitor for the research of acute myeloid leukemia (AML) or solid tumors. Milademetan (DS-3032) induces G1 cell cycle arrest, senescence and apoptosis.