MK-8876|MK 8876;MK8876

Cas No.:	1426960-33-9
Chemical Name:	2-(4-Fluorophenyl)-5-(11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-[methyl(methylsulfonyl)amino]-3-benzofurancarboxamide
Synonyms:	MK 8876;MK8876
SMILES:	O1C2=CC(N(C)S(C)(=O)=O)=C(C3N=C4C5=CC6=C(N5COC4=CC=3)C=CC=C6F)C=C2C(C(NC)=O)=C1C1=CC=C(F)C=C1
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A novel, broadly acting non-nucleoside inhibitor of HCV NS5B polymerase with IC50 of 3 nM and 2 nM for GT1b and GT2a, respectively; demonstrates a pan-genotypic potency profile and maintains potency against clinically relevant mutants; has moderate bioavailability in rats and dogs, but shows low plasma clearance characteristics consistent with once-daily dosing.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC8612	Simeprevir(TMC-435)	Simeprevir (TMC 435350) is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM).
DC8178	Beclabuvir(BMS-791325)	non-nucleoside inhibitor of the NS5B
DC11494	INX-08189	INX-08189 is a phosphoramidate prodrug of O-6-methyl-2-C-methyl guanosine, potent inhibitor of HCV NS5B polymerase with IC50 of 10 nM in replicon assay.
DC11081	Coblopasvir	Coblopasvir (KW136, KW-136) is a novel HCV NS5A inhibitor under development for treatment of HCV infection..
DC7541	Balapiravir	Balapiravir (R1626, Ro 4588161) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479).
DC11731	Ruzasvir	A potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively..
DC11825	MK-8876	A novel, broadly acting non-nucleoside inhibitor of HCV NS5B polymerase with IC50 of 3 nM and 2 nM for GT1b and GT2a, respectively.
DC11823	BMS-929075	A highly potent, selective, orally bioavailable HCV NS5B polymerase inhibitor with IC50 of 9, 4, and 18 nM for GT1a, GT1b, and GT1b-C316N mutant in HCV replicon assay, respectively.