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SU-909

  Cat. No.:  DC21710   Featured
Chemical Structure
2126749-48-0
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More than 5000 active chemicals with high quality for research!
Field of application
SU-909 (SU909, IKKα-IN-48) is a potent, selective IKKα inhibitor with Ki of 0.08±0.07 uM, 10-20-fold selectivity over IKKβ (IC50=1.0±0.28 uM); inhibits FCS-stimulated phosphorylation of p100 in U2OS cells with IC50 of 8.8 uM, inhibits the noncanonical NF-kB pathway without affecting IKKβ-dependent IKappa-Bα loss in the canonical pathway.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2126749-48-0
Chemical Name: 4-(2-Amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzenesulfonamide
Synonyms: BDBM50257823;4-(2-Amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzenesulfonamide
SMILES: S(C1C=CC(=CC=1)C1=C2C(C#N)=CNC2=NC(N)=N1)(N)(=O)=O
Formula: C13H10N6O2S
M.Wt: 314.322499752045
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Anthony NG, et al. J Med Chem. 2017 Aug 24;60(16):7043-7066.
Description: SU-909 (SU909, IKKα-IN-48) is a potent, selective IKKα inhibitor with Ki of 0.08±0.07 uM, 10-20-fold selectivity over IKKβ (IC50=1.0±0.28 uM); inhibits FCS-stimulated phosphorylation of p100 in U2OS cells with IC50 of 8.8 uM, inhibits the noncanonical NF-kB pathway without affecting IKKβ-dependent IKappa-Bα loss in the canonical pathway.
References: References 1. Anthony NG, et al. J Med Chem. 2017 Aug 24;60(16):7043-7066. View Related Products by Target IκB kinase (IKK)
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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