| Cas No.: | 1263303-95-2 |
| SMILES: | O=C(/C(=N/O)/C#N)NC1C=CC(C2C=CC=CC=2)=CC=1 |
| Formula: | C15H11N3O2 |
| M.Wt: | 265.27 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: | [1]. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92. |
| Description: | DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03[1]. |
| Target: | pKa: 5.03 (DHODH)[1] |
| In Vitro: | Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 14a), is designed. Compound 14a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-11 (Compound 14b). DHODH-IN-14 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1]. |
| References: | [1]. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92. |
MSDS
| TITLE | DOWNLOAD |
| MSDS_12967_DC28916_1263303-95-2 |
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COA
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