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GSK2245035

  Cat. No.:  DC28386   Featured
Chemical Structure
1207629-49-9
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More than 5000 active chemicals with high quality for research!
Field of application
GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 is used for asthma.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1207629-49-9
Chemical Name: GSK2245035
Synonyms: GSK2245035;5L3SX16QBQ;GTPL9254;LFMPVTVPXHNXOT-HNNXBMFYSA-N;SB19815;compound 32 [PMID: 26861551];J3.609.218A;(S)-6-amino-2-(pentan-2-yloxy)-9-(5-(piperidin-1-yl)pentyl)-7,9-dihydro-8H-purin-8-one;6-amino-2-[(2S)-pentan-2-yloxy]-9-[5-(piperidin-1-yl)pentyl]-8,9-dihydro-7H-purin-8-one;6-amino-2-{[(1S)-1-methylbutyl]oxy}-9[5-(1-piperidinyl) pentyl]-7,9-dihydro-8H-purin-8-one;8H-Purin-8-one, 6-amino-7;8H-Purin-8-one, 6-amino-7,9-dihydro-2-((1S)-1-methylbutoxy)-9-(5-(1-piperidinyl)pentyl)-;6-amino-2-[(2S)-pentan-2-yl]oxy-9-(5-piperidin-1-ylpentyl)-7H-purin-8-one;GSK-2245035;HY-118250;F3409-0744;AKOS032954203;DA-63925;compound 32 (PMID: 26861551);6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one;6-amino-7,9-dihydro-2-[(1S)-1-methylbutoxy]-9-[5-(1-piperidinyl)pentyl]-8H-purin-8-one;6-amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl) pentyl]-7,9-dihydro-8H-purin-8-one;G16656;CHEMBL4297492;SCHEMBL565847;NSC-853260;GLXC-15811;UNII-5L3SX16QBQ;CS-0065520;6-amino-2-((1-methylbutyl)oxy)-9-(5-(1-piperidinyl)pentyl)-7,9-dihydro-8H-purin-8-one;MS-26512;1207629-49-9;NSC853260
SMILES: O(C1N=C(C2=C(N=1)N(C(N2)=O)CCCCCN1CCCCC1)N)[C@@H](C)CCC
Formula: C20H34N6O2
M.Wt: 390.522964000702
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC70332 CU-CPD107 CU-CPD107 is a TLR8-specific small molecule with unique synergistic agonist activities in the presence of ssRNA, but inactive without the aid of ssRNA.CU-CPD107 significantly inhibited of R848-induced signaling in HEK-Blue hTLR8 cells with an IC50 of 13.7 uM.CU-CPD107 only inhibited synthesized small-molecule agonist-induced TLR8 signaling without affecting other TLRs.CU-CPD107 synergistically increased IFN-β, TNF-α, IL-1β, IL-6, and IL-8 mRNA expression levels in the presence of 5 μg/ml ssRNA40 in HEK-Blue hTLR8 cells, whereas CU-CPD107 alone did not. CU-CPD107 only activated TLR8-mediated signaling in the presence of ssRNA.CU-CPD107 showed no pure agonistic activity, addressing a major challenge that has existed for previous TLR7 and TLR8 agonists as vaccine adjuvants or antiviral drugs.
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DC28386 GSK2245035 GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 is used for asthma.
DC10276 C29 C29 is a potential TLR2 inhibitor.
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