| Cas No.: | 1562338-42-4 |
| Chemical Name: | Branaplam |
| Synonyms: | LMI070;Branaplam;LMI-070;NVS-SM1;Branaplam free base;5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenol;P12R69543A;(6Z)-3-(1H-pyrazol-4-yl)-6-[3-(2,2,6,6-tetramethylpiperidin-4-yl)oxy-1H-pyridazin-6-ylidene]cyclohexa-2,4-dien-1-one;Branaplam [INN];Branaplam (LMI070);LMI070 (NVS-SM1);BCP19909;BDBM50465914;s6642;DB14918;Q27285 |
| SMILES: | O(C1C([H])=C([H])C(C2C([H])=C([H])C(C3C([H])=NN([H])C=3[H])=C([H])C=2O[H])=NN=1)C1([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H] |
| Formula: | C22N5O2H27 |
| M.Wt: | 393.4821 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | LMI070 (Branaplam) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. |
| References: | [1]. Palacino J, et al. SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice. Nat Chem Biol. 2015 Jul;11(7):511-517. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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