L-701,324

Cas No.:	142326-59-8
Chemical Name:	2(1H)-Quinolinone,7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-
Synonyms:	2(1H)-Quinolinone,7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-;7-Chloro-1-(4-hydroxy-3-phenoxyphenyl)-quinolin-2(1H)-one;7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone;7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one;L-701,324;Sulprostone;7-Chloro-4-hydroxy-3-(3-phenoxy)phenylquinolin-2[1H]-one;L 701324;L-701324
SMILES:	O=C1NC2=C(C=CC(Cl)=C2)C(O)=C1C3=CC=CC(OC4=CC=CC=C4)=C3
Formula:	C21H14NO3Cl
M.Wt:	363.79376
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.Target: NMDA ReceptorL-701324 is a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents. L-701324 exhibits a beneficial action in the animal model of parkinsonian rigidity, but not that of parkinsonian akinesia. L-701324 (2.5-40 mg/kg, i.p.) dose-dependently decreased the muscle tone enhanced by haloperidol (1-5 mg/kg, i.p.).

References:

[1]. Piotr Wlaz, et al. Differential effects of glycine on the anticonvulsant activity of D-cycloserine and L-701,324 in mice. Pharmacological Reports 2011,63,1231-1234