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Nitrobenzylthioinosine

  Cat. No.:  DC42123   Featured
Chemical Structure
38048-32-7
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More than 5000 active chemicals with high quality for research!
Field of application
Nitrobenzylthioinosine is an ENT1 transporter inhibitor that binds to ENT1 transporter with high affinity. Nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Nitrobenzylthioinosine can cross the blood-brain barrier.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 38048-32-7
Chemical Name: Inosine,6-S-[(4-nitrophenyl)methyl]-6-thio-
Synonyms: Inosine,6-S-[(4-nitrophenyl)methyl]-6-thio-;S-(4-Nitrobenzyl)-6-thioinosine;NBMPR;S-(4-Nitrobenzyl)-6-;6-S-[(4-Nitrophenyl)methyl]-6-thioinosine;NBTI
SMILES: [N+](C1C=CC(CSC2=NC=NC3=C2N=CN3C2OC(CO)C(O)C2O)=CC=1)([O-])=O
Formula: C17H17N5O6S
M.Wt: 419.411782026291
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
Description: Nitrobenzylthioinosine is an ENT1 transporter inhibitor that binds to ENT1 transporter with high affinity. Nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Nitrobenzylthioinosine can cross the blood-brain barrier[1][2][3].
Target: ENT1 transporter[1]
References: [1]. Lauri Alanko, et al. Nitrobenzylthioinosine (NBMPR) binding and nucleoside transporter ENT1 mRNA expression after prolonged wakefulness and recovery sleep in the cortex and basal forebrain of rat. J Sleep Res. 2003 Dec;12(4):299-304. [2]. C M Anderson, et al. Ability of nitrobenzylthioinosine to cross the blood-brain barrier in rats. Neurosci Lett. 1996 Nov 29;219(3):191-4. [3]. P J Marangos, et al. [3H]nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Eur J Pharmacol. 1982 Dec 3;85(3-4):359-60.
MSDS
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