C14-490(C14-3)|CAS 2639634-82-3|DC Chemicals

Cas No.:	2639634-82-3
Chemical Name:	C14-490
Synonyms:	1,1′-[[3-[4-[2-[[3-[bis(2-hydroxytetradecyl)amino]-2-ethoxypropyl](2-hydroxytetradecyl)amino]ethyl]-1-piperazinyl]-2-ethoxypropyl]imino]bis-2-tetradecanol;C14490 C14 490
SMILES:	OC(CCCCCCCCCCCC)CN(CC(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)OCC)CCN1CCN(CC(CN(CC(O)CCCCCCCCCCCC)CC(CCCCCCCCCCCC)O)OCC)CC1
Formula:	C₈₆H₁₇₇N₅O₇
M.Wt:	1393.4
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC67283	C14-490	C14-490 is an ionizable cationic lipid (pKa = 5.94).1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.C14-490-containing LNPs accumulate primarily in the fetal mouse liver and, to a lesser extent, in the lungs, intestine, and brain after vitelline vein injection on gestational day 16 (E16).1 CD45-functionalized LNPs containing C14-490 and encapsulating mRNA encoding GFP transfect Jurkat cells, which constitutively express the CD45 receptor (CD45R).C14-490-containing CD45-functionalized LNPs encapsulating Cre mRNA mediate genome modulation in bone marrow hematopoietic stem cells (HSCs) for at least four months after in utero injection in R26mT/mG mice at E13.5.