C14-490(C14-3)|CAS 2639634-82-3|DC Chemicals

Cas No.:	2639634-82-3
Chemical Name:	C14-490
Synonyms:	1,1′-[[3-[4-[2-[[3-[bis(2-hydroxytetradecyl)amino]-2-ethoxypropyl](2-hydroxytetradecyl)amino]ethyl]-1-piperazinyl]-2-ethoxypropyl]imino]bis-2-tetradecanol;C14490 C14 490
SMILES:	OC(CCCCCCCCCCCC)CN(CC(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)OCC)CCN1CCN(CC(CN(CC(O)CCCCCCCCCCCC)CC(CCCCCCCCCCCC)O)OCC)CC1
Formula:	C₈₆H₁₇₇N₅O₇
M.Wt:	1393.4
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC67283	C14-490	C14-490 is an ionizable cationic lipid (pKa = 5.94).1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.C14-490-containing LNPs accumulate primarily in the fetal mouse liver and, to a lesser extent, in the lungs, intestine, and brain after vitelline vein injection on gestational day 16 (E16).1 CD45-functionalized LNPs containing C14-490 and encapsulating mRNA encoding GFP transfect Jurkat cells, which constitutively express the CD45 receptor (CD45R).C14-490-containing CD45-functionalized LNPs encapsulating Cre mRNA mediate genome modulation in bone marrow hematopoietic stem cells (HSCs) for at least four months after in utero injection in R26mT/mG mice at E13.5.
DC66221	E12CA1A3	E12CA1A3 is an ionizable cationic lipid (pKa = 6.4) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing E12CA1A3 and encapsulating an mRNA reporter induce luciferase reporter expression in mouse bone marrow-derived dendritic cells (BMDCs) and mice. LNPs containing E12CA1A3 are cleared more rapidly from the liver than LNPs containing DLin-MC3-DMA (Item No. 34364) in mice.
DC80070	A2-Iso5-2DC18	A2-Iso5-2DC18 is a top-performing lipid for mRNA delivery in bone marrow-derived dendritic cells (BMDCs), BMDMs and HeLa cells.