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PF-06648671

  Cat. No.:  DC21501   Featured
Chemical Structure
1587727-31-8
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More than 5000 active chemicals with high quality for research!
Field of application
PF-06648671 is a potent γ-secretase modulator with IC50 of 8.9 nM against Aβ42. PF-06648671 has favorable brain availability in rodent, which translated into excellent central exposure in human and robust reduction of amyloid β (Aβ) 42 in cerebrospinal fluid (CSF).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1587727-31-8
Chemical Name: 2H-Pyrido[1,2-a]pyrazine-1,6-dione, 2-[(1S)-1-[(2S,5R)-5-[4-chloro-5-fluoro-2-(trifluoromethyl)phenyl]tetrahydro-2-furanyl]ethyl]-3,4-dihydro-7-(4-methyl-1H-imidazol-1-yl)-
Synonyms: PF6648671
Formula: C25H23ClF4N4O3
M.Wt: 538.928
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: PF-06648671 (PF6648671) is a novel oral γ-secretase modulator being developed for the treatment of Alzheimer's disease.Alzheimer DiseasePhase 1 Discontinued
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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