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UC-764864

  Cat. No.:  DC70861   Featured
Chemical Structure
2566480-62-2
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More than 5000 active chemicals with high quality for research!
Field of application
UC-764864 (UC764864) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2566480-62-2
Chemical Name: UC-764864
Synonyms: 2-Propen-1-one, 1-(4-ethylphenyl)-3-[(6-methyl-1H-benzimidazol-2-yl)thio]-, (2Z)-
SMILES: C(C1=CC=C(CC)C=C1)(=O)/C=C\SC1NC2=CC(C)=CC=C2N=1
Formula: C19H18N2Os
M.Wt: 322.424023151398
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_35074_DC70861_2566480-62-2
COA
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Cat. No. Product name Field of application
DC74330 HA-9104 HA-9104 is a specific small molecule inhibitor of E2 conjugating enzyme UBE2F with IC50 of 33.29 uM for inhibition of cullin-5 neddylation, abrogates UBE2F-NEDD8 thioester formation and inhibits cullin-5 neddylation.
DC70862 UC-764865 UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764865 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro.
DC70861 UC-764864 UC-764864 (UC764864) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro.
DC70605 ML307 ML307 is a potent, sub-micromolar (IC50=781 nM), first-in-class, small molecule inhibitor of Ubc13 enzyme activity, >128-fold selective against Caspase-3 and Bfl-1.
DC47678 M435-1279 M435-1279 is a UBE2T inhibitor. M435-1279 acts inhibit the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1.
DC9431 TZ9 TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM.
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