| Cas No.: | 1931994-81-8 |
| Chemical Name: | Zabedosertib |
| Synonyms: | Zabedosertib;N-[6-(1-hydroxy-1-methyl-ethyl)-2-(2-methylsulfonylethyl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide;N1GRK350ZM;BAY1834845;N-[6-(2-hydroxypropan-2-yl)-2-(2-methylsulfonylethyl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide;Zabedosertib [INN];GTPL11415;BDBM395297;US10308634, Example 12;SB74225;BAY 1834845;D96922;2-Pyridinecarboxamide, N-(6-(1-hydroxy-1-methylethyl)-2-(2-(methyl |
| SMILES: | S(C([H])([H])[H])(C([H])([H])C([H])([H])N1C([H])=C2C([H])=C(C(=C([H])C2=N1)C(C([H])([H])[H])(C([H])([H])[H])O[H])N([H])C(C1C([H])=C([H])C([H])=C(C(F)(F)F)N=1)=O)(=O)=O |
| Formula: | C20H21F3N4O4S |
| M.Wt: | 470.4654 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: | [1]. Bothe, Ulrich; Siebenreicher, Holger; Schmidt, Nicole; Nubbemeyer, Reinhard; Boemer, Ulf; Guenther, Judith; Steuber, Holger; Lange, Martin; Stegmann, Christian; Sutter, Andreas; et al.New substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to produce drugs.WO2016083433A1 |
| Description: | Zabedosertib (BAY 1834845) is a IRAK4 inhibitor with immunomodulatory potential. IRAK4 is a protein kinase involved in signaling innate immune responses from Toll-like receptors. |
| References: | [1]. Bothe, Ulrich; Siebenreicher, Holger; Schmidt, Nicole; Nubbemeyer, Reinhard; Boemer, Ulf; Guenther, Judith; Steuber, Holger; Lange, Martin; Stegmann, Christian; Sutter, Andreas; et al.New substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to produce drugs.WO2016083433A1 |
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