6-[1-(Hexyloxy)ethoxy]hexanal is the tail fragement for MK16.MK16 is a novel blood-brain barrier (BBB)-crossing lipid nanoparticle (BLNP) platform developed for efficient mRNA delivery to the central nervous system (CNS).

SM-6.1 is a small molecule delivery vehicle developed by Arrowhead, targeting αvβ6, which selectively delivers therapeutic siRNA to lung epithelial cells and mediates durable gene silencing post-inhalation.

2-[(2-aminoethyl)(methyl)amino]ethanol, also known as N,N-bis(2-aminoethyl)methylamine, is an organic compound characterized by its amine functional groups. It features a primary amine and a secondary amine, contributing to its reactivity and ability to form hydrogen bonds. This compound is typically a colorless to pale yellow liquid with a relatively high boiling point, indicating significant intermolecular interactions. It is soluble in water due to the presence of hydroxyl and amine groups, which enhance its polarity. The substance is often used in various applications, including as a building block in the synthesis of surfactants, pharmaceuticals, and other chemical intermediates. Its basicity allows it to act as a ligand in coordination chemistry. Additionally, it may exhibit biological activity, making it of interest in medicinal chemistry. Safety precautions should be taken when handling this compound, as it may cause irritation to the skin and eyes. Proper storage conditions are essential to maintain its stability and prevent degradation.

Tail of CICL-1 lipid

Oleyl bromide ((Z)-1-Bromooctadec-9-ene) is a hydrophobic compound that can carry out ring-opening reaction through a process called "encapsulation". Oleyl bromine can also be used as the starting material in the synthesis of oleylphosphonates.

This study developed CRD-PEG-T7, a prostate cancer-targeting gene delivery system featuring a disulfide-crosslinked arginine-aspartic acid peptide vector modified with T7 targeting ligands for selective pDNA delivery in PCa gene therapy.

1,2-O-Dioctadecyl-sn-glycerol (Compound 7b) is a lipid-based molecule that serves as a key component in the synthesis of thermostable lipid nanoparticles, enhancing their stability and functionality.

Azido-acetal linker is stable at physiological pH (7.4) but rapidly hydrolyzes in the acidic environment of endosomes useful as a fragment of lipid synthesis.

C14-4 Core (Core 4) is the core structure of C14-4.

MK-0752 is a moderately potent γ-secretase inhibitor, it is used as a head group of MK16 which is a a novel blood-brain barrier (BBB)-crossing lipid nanoparticle (BLNP) platform developed for efficient mRNA delivery to the central nervous system (CNS).