| DC2066 |
Apoptosis Activator 2
Featured
|
Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells. |
|
| DC2015 |
AT-101 (AT101) |
AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members. |
|
| DC8232 |
AZD5582
Featured
|
AZD5582 is a novel class of dimeric Smac mimetics as potent IAP antagonist; binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC50 = 15, 21, and 15 nM, respectively). |
|
| DC9695 |
BH3I-1
Featured
|
BH3I-1 is a cell permeable BH3 mimetic that binds to Bcl-xL. BH3I-1 is an inhibitor of Bcl-xL. |
|
| DC7603 |
Bioymifi
Featured
|
Bioymifi(DR5 Activator) is the first novel and potent small-molecule activatior of the TRAIL receptor DR5 in human cancer cells. |
|
| DC10966 |
BRD1991 |
BRD1991 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity.. |
|
| DC7563 |
BV6
Featured
|
BV6 induced apoptotic and necrotic cell death in monocytes while T-cells, dendritic cells and
macrophages were largely protected against BV6-induced cell death. |
|
| DC11219 |
BXI-72
Featured
|
BXI-72 (NSC334072) is a potent, selective small molecule Bcl-XL inhibitor that targets the BH3 domain of Bcl-XL (Kd=0.9 nM). |
|
| DC10419 |
C 87 |
C87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM. |
|
| DC8113 |
Carubicin
Featured
|
Carubicin is an anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata. |
|
| DC7568 |
Z-DEVD-FMK
Featured
|
Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo. |
|
| DC9955 |
BCL6 inhibitor(CID5721353)
Featured
|
CID5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor). |
|
| DC7385 |
CID-755673
Featured
|
CID755673 is a potent and selective cell-active small molecule inhibitor for PKD with an IC50 of 182 nM; exhibits selective PKD1 inhibition when compared with AKT, PLK1, CAK, CAMKIIα, and PKC isoforms. |
|
| DC10839 |
CIL56(CA3)
Featured
|
CIL56 is a small molecule that induces cellular ferroptosis through production of iron-dependent reactive oxygen species (ROS). |
|
| DC10657 |
COTI-2
Featured
|
COTI-2 is a small molecule candidate anti-cancer drug which can convert mutant p53 to wild-type conformation. |
|
| DC11726 |
Milademetan
Featured
|
Milademetan (DS-3032) is a specific and orally active MDM2 inhibitor for the research of acute myeloid leukemia (AML) or solid tumors. Milademetan (DS-3032) induces G1 cell cycle arrest, senescence and apoptosis. |
|
| DC10400 |
Ecteinascidin 770 |
Ecteinascidin 770 (ET-770) is a 1,2,3,4-tetrahydroisoquinoline alkaloid with potent anti-cancer activities; inhibits U373MG cells with an IC50 of 4.83 nM. |
|
| DC3156 |
Elesclomol (STA-4783)
Featured
|
Elesclomol (STA-4783) is a novel potent oxidative stress inducer that illicits pro-apoptosis events among tumor cells.. |
|
| DC9762 |
Emricasan
Featured
|
Emricasan (IDN-6556, PF-03491390) is a potent irreversible pan-caspase inhibitor. |
|
| DC10742 |
Ferrostatin-1 (Fer-1)
Featured
|
Ferrostatin-1 is a selective inhibitor of erastin induced ferroptosis with EC50 value of 60 nM. |
|
| DC10522 |
FIN56
Featured
|
FIN56 is a specific inducer of ferroptosis. |
|
| DC10972 |
Flavokawain B |
Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM), via up-regulation of death-receptor 5 and Bim expression. |
|
| DC10447 |
FX1
Featured
|
FX1 is a novel specific inhibitor of the B cell lymphoma 6 (BCL6). |
|
| DC10133 |
Gambogic Acid
Featured
|
Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-xl, Bcl-2, Bcl-w, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM, respectively. |
|
| DCAPI1148 |
Gossypol |
Gossypol |
|
| DC10787 |
GSK2982772
Featured
|
GSK2982772 is a potent and ATP competitive RIP1 inhibitor with an IC50 of 16 nM. |
|
| DC9721 |
GSK2983559 active metabolite
Featured
|
GSK2983559 active metabolite is an active metabolite of GSK2983559. GSK2983559 active metabolite is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1. |
|
| DC9733 |
GSK583
Featured
|
GSK583 is a Highly Potent and Selective Inhibitor of RIP2 Kinase (RIP2K bing IC50=5 nM; rat in vivo PD IC50 = 50 nM). |
|
| DC10471 |
GSK-872
Featured
|
GSK-872 is a potent and selective RIPK3 (receptor-interacting protein kinase-3) inhibitor. |
|
| DC1066 |
HA14-1
Featured
|
HA14-1 is a nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of~9 μM. |
|
