| DC10613 |
NVP-HDM201(Siremadlin )
Featured
|
HDM201 is an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity. |
|
| DC12045 |
HS-1371
Featured
|
HS-1371 is a novel kinase inhibitor of RIP3-mediated necroptosis. |
|
| DC11128 |
HS148
Featured
|
HS148 (DAPK3 inhibitor HS148) is a selective DAPK3 inhibitor with Ki of 119 nM, >10-fold selectivity over Pim kinases.. |
|
| DC11126 |
HS56 |
HS56 (Pim-DAPK3 inhibitor HS56) is a potent, dual Pim/DAPK3 inhibitor with Ki of 72 nM (Pim-3) and 315 nM (DAPK3), shows micromolar potency toward Pim-1 and Pim-2 (Ki=1.5 and 17 uM). |
|
| DC11127 |
HS94
Featured
|
HS94 (DAPK3 inhibitor HS94) is a selective DAPK3 inhibitor with Ki of 126 nM, >20-fold selectivity over Pim kinases.. |
|
| DC10361 |
Iberin
Featured
|
Iberin, a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. It inhibits cell survival with an IC50 of 2.3 μM in HL60 cell. |
|
| DC7175 |
JNJ-26854165 (Serdemetan)
Featured
|
JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. |
|
| DC8084 |
kb NB 142-70
Featured
|
kb NB 142-70 is a selective protein kinase D (PKD) inhibitor. |
|
| DC11627 |
KEA1-97
Featured
|
KEA1-97 (KEA 1-97) is a small molecule that disrupts the interaction of thioredoxin with caspase 3. |
|
| DC10041 |
KR-33494
Featured
|
KR-33494 is a fluorescent-tagged and biotin-tagged probe of a potent inhibitor for Fas-mediated cell death (FAF1), KR-33493. |
|
| DC10777 |
Leonurine
Featured
|
Leonurine, a natural alkaloid extracted from Herba leonuri, has been proved to have anti-inflammatory effect. |
|
| DC7920 |
Liproxstatin-1
Featured
|
Liproxstatin-1 is able to suppress ferroptosis in cells, in Gpx4(-/-) mice, and in a pre-clinical model of ischaemia/reperfusion-induced hepatic damage. |
|
| DC10958 |
MB710 |
MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro.. |
|
| DC10957 |
MB725
Featured
|
MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM). |
|
| DC8414 |
MI-77301 (SAR405838)
Featured
|
MI-77301 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1. |
|
| DC8264 |
MM-41 |
MM41 is a quadruplex-interactive compound which binds strongly to the quadruplexes encoded in the promoter sequences of the BCL-2 and k-RAS genes. |
|
| DC10074 |
MX69
Featured
|
MX69 is the MDM2/XIAP inhibitor, used for cancer treatment. |
|
| DC7879 |
NSC 66811 |
NSC 66811 is a potent MDM2 inhibitor (Ki = 120 nM). |
|
| DC8746 |
NSC319726
Featured
|
NSC319726 is a mutant p53R175 reactivator; inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM); shows no inhibition for p53 wild-type cells. |
|
| DC9257 |
NSC59984
Featured
|
NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway.The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 μM for p53-null HCT116 cells. |
|
| DC3125 |
Nutlin-3
Featured
|
Nutlin 3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM. |
|
| DC8454 |
Nutlin-3a
Featured
|
Nutlin-3a is arbitrarily referred to as enantiomer a because it appears as the first peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known. |
|
| DC8455 |
Nutlin-3b |
Nutlin-3b is 150-fold less potent as an inhibitor of p53-MDM2 interaction than (−)-nutlin-3, demonstrating an IC50 value of 13.6 µM. |
|
| DC7217 |
Obatoclax (GX15-070)
Featured
|
Obatoclax (GX15-070) is Bcl-2 homology domain-3 (BH3) mimetic, antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L). |
|
| DC8144 |
Pifithrin-β (hydrobromide)
Featured
|
Pifithrin-β HBr (Cyclic Pifithrin-α HBr) is a potent p53 inhibitor with IC50 of 23 uM in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1. |
|
| DC7233 |
Pifithrin-u
Featured
|
Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy. |
|
| DC9902 |
PRIMA-1
Featured
|
PRIMA-1 is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A. |
|
| DC10070 |
PRIMA-1MET(APR-246)
Featured
|
PRIMA-1MET is methylated derivative of PRIMA-1. It can restore mutant p53 activity. |
|
| DC8128 |
Pyridoclax(MR29072)
Featured
|
Pyridoclax(MR-29072) is a potent Mcl-1 inhibitor with Kd value of 25 nM. |
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|
| DC9283 |
Q-VD-Oph
Featured
|
Q-VD-Oph is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9. |
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