Cat. No. | Product name | CAS No. |
DC7081 |
PF-04217903
Featured
PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM, susceptible to oncogenic mutations (no activity to Y1230C mutant). |
956905-27-4 |
DC8353 |
PF-04418948
Featured
PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM). |
1078166-57-0 |
DC11367 |
PF-04447943
Featured
PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis. |
1082744-20-4 |
DC7027 |
Glasdegib(PF-04449913)
Featured
PF-04449913 is a potent and orally bioavailable inhibitor of smoothened with IC50 of 5 nM(Gli-luciferase reporter reporter in C3H10T1/2); the hedgehog pathway inhibitor |
1095173-27-5 |
DC9442 |
PF-04457845
Featured
PF-04457845 is a potent and exquisitely selective inhibitor of FAAH, with an IC50 of 7.2 nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen. |
1020315-31-4 |
DC7227 |
PF-04620110
Featured
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. |
1109276-89-2 |
DC23600 |
PF-04856264
Featured
PF-04856264 is a potent, selective Nav1.7 blocker with IC50 of 28 nM, dispalys >1,000-fold selectivity over Nav1.5. |
1235397-05-3 |
DC8727 |
PF-04880594
Featured
PF-04880594 is an inhibitor of RAF with IC50 values of 0.19 nM/0.13 nM and 0.39 nM for BRAF/BRAFV599E and c-RAF, respectively. |
1111636-35-1 |
DC9948 |
SNX-5422(PF04929113)
Featured
PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor (Kd of 41 nM). PF-04929113 also inhibits Her-2 degradation (IC50 of 37 nM). |
908115-27-5 |
DC20164 |
PF-04965842 (Abrocitinib)
Featured
PF-04965842 is a potent JAK1 inhibitor with IC50s of 29 nM, 803 nM, > 10 000 nM and 1250 nM for JAK1, JAK2, JAK3 and tyrosine kinase (TYK) 2, respectively. |
1622902-68-4 |
DC3108 |
PF-04971729 (Ertugliflozin)
Featured
PF-04971729 is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2, is currently in phase 2 trials for the treatment of diabetes mellitus. |
1210344-57-2 |
DC9915 |
PF04995274,PF 04995274
Featured
PF-04995274 is a 5-HT4 receptor partial agonist. It thought to act centrally as a pro-cognitive agent that being developed for the treatment of Alzheimer's disease (AD). |
1331782-27-4 |
DC21486 |
PF-05150122
Featured
PF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.. |
1235406-03-7 |
DC10050 |
PF05175157
Featured
PF-05175157 is a potent and selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 located primarily in liver and adipose tissue and isoform ACC2 dominant in skeletal and heart muscle, with IC50 values of 27 nM and 33 nM, respectively. |
1301214-47-0 |
DC11937 |
PF 05180999
Featured
PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM. |
1394033-54-5 |
DC26091 |
PF-05198007
Featured
PF-05198007 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 9 nM, no significant activity against Nav1.5 (IC50>10 uM). |
1235406-19-5 |
DC20145 |
PF-05231023
Featured
PF-05231023, a long-acting fibroblast growth factor 21 (FGF21) analog, is a FGF21-receptor agonist, suitable for development as a potential treatment for T2DM. |
1037589-69-7 |
DC21476 |
PF-05381941
Featured
PF-05381941 (PF 05381941, PF05381941) is a potent, dual TAK1/p38a inhibitor with IC50 of 156/186 nM respectively, with good kinome selectivity against 50 representative kinases. |
1474022-02-0 |
DC12518 |
PF-06256142
Featured
PF-06256142 (PF06256142) is a potent and selective orthosteric agonist of the D1 receptor with EC50 (cAMP) of 33 nM, shows exquisitely selectivity over D2. |
1609583-14-3 |
DC10500 |
PF-06282999
Featured
PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases. |
1435467-37-0 |
DC12594 |
PF-06305591
Featured
PF-06305591 (PF06305591) is a potent, highly selective selective NaV1.8 blocker with IC50 of 15 nM, displays no significant activity against other sodium channel subtypes, K+ channels and Ca2+ channels. |
1449473-97-5 |
DC21488 |
PF-06372865
Featured
PF-06372865 is a novel potent, α2/3 functionally selective GABAA receptor positive allosteric modulator. |
1614245-70-3 |