Cat. No. | Product name | CAS No. |
DC11466 |
PF-06409577
Featured
PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM. |
1467057-23-3 |
DC22783 |
PF-06446846
Featured
PF-06446846 (PF-6446846) is a potent, highly selective inhibitor of PCSK9 translation with IC50 of 0.3 uM for inhibition the secretion of PCSK9 by Huh7 cells. |
1632250-49-7 |
DC7971 |
PF-06447475
Featured
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively. |
1527473-33-1 |
DC11288 |
PF-06454589
Featured
PF-06454589 is a potent and selective LRRK2 inhibitor. |
1527473-30-8 |
DC7924 |
PF06463922(Lorlatinib)
Featured
PF06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity. |
1454846-35-5 |
DC21501 |
PF-06648671
Featured
PF-06648671 is a potent γ-secretase modulator with IC50 of 8.9 nM against Aβ42. PF-06648671 has favorable brain availability in rodent, which translated into excellent central exposure in human and robust reduction of amyloid β (Aβ) 42 in cerebrospinal fluid (CSF). |
1587727-31-8 |
DC24082 |
PF-06650833
Featured
PF06650833 is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0.2 and 2.4 nM in the cell and PBMC assay, respectively. PF06650833 is used to treat diseases such as rheumatoid arthritis, l |
1817626-54-2 |
DC10779 |
PF-06651600
Featured
PF-06651600 is a potent JAK3-selective inhibitor with an IC50 of 33.1 nM. |
1792180-81-4 |
DC12489 |
PF-06700841 free base
Featured
PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus. |
1883299-62-4 |
DC12488 |
PF-06700841 tosylate
Featured
PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus. |
2140301-96-6 |
DC20067 |
PF-06737007
Featured
PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect. |
1863905-38-7 |
DC10022 |
PF06840003
Featured
PF-06840003 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1),with potential immunomodulating and antineoplastic activities. |
198474-05-4 |
DC10834 |
PF-06869206
Featured
PF-06869206 is an Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). |
2227425-05-8 |
DC22194 |
PF-06873600
Featured
PF-06873600 (PF06873600, PF 06873600) is a potent, orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively. |
2185857-97-8 |
DC21478 |
PF-06928215
Featured
PF-06928215 (PF06928215) is a high affinity Cyclic GMP-AMP synthase (cGAS) inhibitor with Kd of 200 nM, IC50 of 4.9 uM. |
2378173-15-8 |
DC2047 |
Crizotinib (PF-2341066)
Featured
PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nnM, respectivley. |
877399-52-5 |
DC7201 |
PF-2545920(MP-10)
Featured
PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM. |
898562-94-2 |
DC1091 |
PF-299804 (Dacomitinib,PF-00299804)
Featured
PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively. |
1110813-31-4 |
DC7480 |
PF-3274167(cligosiban)
Featured
PF-3274167 is a high-affinity nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM. |
900510-03-4 |
DC23267 |
PF-3450074
Featured
PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro. |
1352879-65-2 |
DC22797 |
PF-3644022
Featured
PF-3644022 is a potent and selective, freely reversible, ATP-competitive inhibitor of MAPKAP2 (MK2) with Ki of 3 nM. |
1276121-88-0 |
DC8059 |
PF 429242
Featured
PF-429242 is a potent inhibitor of S1P(cellular proprotein convertase sterol regulatory element-binding protein (SREBP) site 1 protease) |
947303-87-9 |