Cat. No. | Product name | CAS No. |
DC8359 |
STF-31
Featured
STF-31 is an inhibitor of GLUT1 (IC50 = ~1 µM) that blocks glucose uptake. |
724741-75-7 |
DC10456 |
STF-62247
Featured
STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). |
315702-99-9 |
DC26063 |
STING Agonist C11
Featured
STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway. |
875863-22-2 |
DC12505 |
STING agonist-4
Featured
STING agonist 4 is an amidobenzimidazole (ABZI)-based compound that functions as a STING agonist with Kd of 1.6 nM (binding of endogenous full-length STING, THP-1 cell lysates); caused dose-dependent phosphorylation of IRF3 and STING that was inhibited by the TBK1 inhibitor BX795, induced dose-dependent secretion of IFN-β with EC50 of 3.1 uM in PBMCs (18-fold more potent than cGAMP); promotes production of IFN-γ-induced protein 10 (IP-10), IL-6 and TNFα by a mechanism that is dependent on STING-mediated activation of TBK1; unlike cGAMP and DMXAA, compound 2 efficiently activates STING function while maintaining an open STING confirmation. |
2138300-40-8 |
DC11451 |
STING agonist compound 1
Featured
diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
2138299-33-7 |
DC10960 |
STING inhibitor C-176
Featured
STING inhibitor C-178 is a covalent, in vivo-active, small-molecule inhibitor of STING |
314054-00-7 |
DC10959 |
STING inhibitor C-178
Featured
STING inhibitor C-178 is a covalent, small-molecule inhibitor of STING, blocks palmitoylation (PMA)-induced clustering of STING; covalently binds to Cys91, directly targets mouse STING (mmSTING) but not human STING (hsSTING). |
329198-87-0 |
DC10201 |
STK16-IN-1
Featured
STK16-IN-1 is a STK16 kinase inhibitor with an IC50 of 295 nM. |
1223001-53-3 |
DC9844 |
STK321130(FLT3-IN-2)
Featured
STK321130(FLT3-IN-2)is potent FLT3 inhibitor |
923562-23-6 |
DC11264 |
STO-609 (acetate)
Featured
STO-609 is a cell-permeable inhibitor of calcium/calmodulin-dependent kinase kinases (CaMKK) isoforms CaMKKα and CaMKKβ (Ki = 80 and 15 ng/ml, respectively). |
1173022-21-3 |
DC9961 |
STO-609
Featured
STO-609 is a selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively); competes for the ATP-binding site. |
52029-86-4 |
DCAPI1552 |
streptomycin
Featured
Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes . |
57-92-1 |
DC21709 |
SU 16f
Featured
SU 16f is a potent and selective PDGFRβ inhibitor with IC50 of 10 nM, displays >14-fold, >229-fold and >10,000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. |
251356-45-3 |
DC10602 |
SU 4313
Featured
SU 4313 is a bioactive chemical. |
186611-55-2 |
DC10601 |
SU 4942
Featured
SU 4942 is a bioactive chemical. |
76086-99-2 |
DC10600 |
SU 5205
Featured
SU 5205 is a VEGFR2 inhibitor. |
3476-86-6 |
DC10519 |
SU 5214
Featured
SU 5214 is a modulator of tyrosine kinase signal transduction. |
186611-04-1 |
DC8102 |
SU6656
Featured
SU 6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). |
330161-87-0 |
DC1093 |
SU11274 (PKI-SU11274)
Featured
SU11274 is a selective Met inhibitor with IC50 of 10 nM. |
658084-23-2 |
DC7302 |
SU14813
Featured
SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), Kit, and fms-like tyrosine kinase 3 (FLT-3). |
627908-92-3 |
DC7509 |
SU1498
Featured
SU1498 is a selective inhibitor of the VEGFR2; inhibits Flk-1with an IC50 of value of 700 nM. |
168835-82-3 |
DC9781 |
SU4312(NSC86429)
Featured
SU4312(NSC86429) is a selective, cell-permeable inhibitor of VEGFR2 and PDGFR tyrosine kinases (IC50s = 0.8 and 19.4 μM, respectively). |
5812-07-7 |