| DC9704 |
Unii-G55ZH52P57
Featured
|
BTZ043 is a inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), It can display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro. |
|
| DCAPI1392 |
BTZ043 racemate
Featured
|
BTZ043 racemate is a decaprenylphosphoryl-β-D-ribose 2-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis. |
|
| DC22041 |
BTZO-1
Featured
|
BTZO-1 is a cardioprotective agent and Macrophage migration inhibitory factor (MIF) activator, binds to MIF with Kd of 68.6 nM, regulates ARE-mediated gene expression. |
|
| DC6501 |
Bufalin
Featured
|
Bufalin inhibits steroid receptor coactivator 1 (SRC-1) and SRC-3 at doses as low as 5 nM, promotes the degradation of SRC-3 protein, and inhibits cancer cell growth both in vitro and in vivo. |
|
| DCAPI1140 |
Bumetanide
Featured
|
Bumetanide |
|
| DC11381 |
Butabindide (oxalate)
Featured
|
Butabindide is a potent inhibitor of cholecystokinin-inactivating peptidase/tripeptidyl peptidase 2 (CCK-inactivating peptidase/TPP-2; Ki = 7 nM).1 It is selective for CCK-inactivating peptidase/TPP-2 over a panel of serine proteases (Kis = >1 μM) as well as CCK receptors (Kis = >0.1 mM). |
|
| DC10693 |
O-Butyryl timolol
Featured
|
Butyryltimolol is a lipophilic ester prodrug of timolol, a beta adrenergic blocer with antihypertensive and hemodynamic properties. |
|
| DC7563 |
BV6
Featured
|
BV6 induced apoptotic and necrotic cell death in monocytes while T-cells, dendritic cells and
macrophages were largely protected against BV6-induced cell death. |
|
| DC8089 |
BVT 2733(BVT.2733)
Featured
|
BVT 2733 is a selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor,protecting osteoblasts against endogenous glucocorticoid induced dysfunction. |
|
| DC8278 |
BVT-14225
Featured
|
BVT 14225 is a new selective 11b-HSD1 inhibitor, it belongs to a class of arylsulfonamidothiazoles with in vitro and in vivo antidiabetic effects |
|
| DC21685 |
BVT-948
Featured
|
BVT-948 (SPS8I-3) is a noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) with IC50 of 0.09-1.7 uM. Results show that the effect of BVT948 (BVT.948) is to strengthen the insulin signal and has no effects on the duration of th |
|
| DC12041 |
BW-A 78U
Featured
|
BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM. |
|
| DC7675 |
BX-471（ZK 811752）
Featured
|
BX471 is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1); exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. |
|
| DC8808 |
BX-513 hydrochloride
Featured
|
BX-513 hydrochloride inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). |
|
| DC8062 |
BX517
Featured
|
BX517 is a novel phosphoinositide-dependent kinase-1 (PDK1) inhibitor. |
|
| DC7092 |
BX795
Featured
|
BX795 is a potent and selective dual inhibitor of TBK1/PDK1 with IC50s of 2 nM/6 nM respectively; > 50 fold selectivity over PKA, PKC, c-Kit, GSK3β etc. |
|
| DC7093 |
BX912
Featured
|
BX-912 is a selective inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1) with IC50 of 12 nM; >10 fold selectivity over PKA, PKC, C-Kit, EGFR etc. |
|
| DC11219 |
BXI-72
Featured
|
BXI-72 (NSC334072) is a potent, selective small molecule Bcl-XL inhibitor that targets the BH3 domain of Bcl-XL (Kd=0.9 nM). |
|
| DC7094 |
Alpelisib(BYL-719)
Featured
|
BYL719 is a potent and selective PI3Kα inhibitor with IC50 of 5 nM, ;liitle or no effect on PI3Kβ/γ/δ. |
|
| DC26049 |
Bz-IEGR-pNA (acetate)
Featured
|
Bz-IEGR-pNA is a colorimetric substrate for Factor Xa. |
|
| DC11453 |
Bz-Nle-Lys-Arg-Arg-AMC
Featured
|
Bz-Nle-Lys-Arg-Arg-AMC is a substrate for dengue virus NS2B-NS3 and yellow fever virus NS3 protease. |
|
| DC10864 |
C188-9
Featured
|
C188-9 is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors. |
|
| DC10937 |
C25-140
Featured
|
C25-140 is a specific, first-in-class small molecule inhibitor of the TRAF6-Ubc13 interaction, binds TRAF6, inhibits TRAF6-Ubc13 interaction and TRAF6 activity. |
|
| DC10276 |
C29
Featured
|
C29 is a potential TLR2 inhibitor. |
|
| DC7658 |
C646
Featured
|
C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM. Preferentially selective for p300 versus other acetyltransferases. |
|
| DC9528 |
C75 (trans)
Featured
|
C75 trans is the trans form of C75; C75 is a potent fatty-acid synthase(FASN) inhibitor with IC50 of 35.4 μM(LNCaP cell Proliferation inhibition).
|
|
| DC7697 |
CA-074-Me
Featured
|
CA-074 Me is a selective and cell-permeable inhibitor of cathepsin B. |
|
| DC10330 |
PD-1-IN-17
Featured
|
PD-1-IN-17 has CAS#CAS:1673560-66-1, which is a programmed cell death-1 (PD-1) inhibitor. PD-1-IN-17 was first reported in patent WO2015033301A1, (Compound 4), inhibits 92% splenocyte proliferation at 100 nM. PD-1-IN-17 may be related to CA-170 (AUPM170), which is a potent PD-1 inhibitor and curreently under clinical trials. |
|
| DC10648 |
CA4948-Analog
Featured
|
CA4948-Analog is an analog of Emavusertib. It has similar property to CA-4948, which is a potent, and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor. It was reported in patent WO 2015104688. Emavusertib, also known as CA-4948 i |
|
| DC12044 |
CA-5f
Featured
|
CA-5f is a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. |
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