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Cat. No. Product name CAS No.
DC65679 BI-2493 Featured

BI-2493 is a structural analogue of BI-2865 and a highly selective pan-KRAS inhibitor. BI-2493 can attenuate tumor growth. BI-2493 can be used for cancer iseases research.

2937344-16-4
DC60503 Lipid C12-A1 Featured

Lipid C12-A1 is an ionizable lipid. C12-A1-LPN is a potent and safe LNP platform to deliver Foxp3 mRNA to CD4+ T cells to engineer immunosuppressive FP3T cells. C12-A1 has a slightly lower average cell viability than C14-A1.

DC65680 Lipid 2-10 Featured

Lipid 2-10 is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure.

2055939-68-7
DC60504 RCS-03-104-4 Featured

RCS-03-104-4 is a cysteine-reactive JQ1 analogue, which potently induces BRD4 degradation with DC50 and Dmax of 79 nM and 71%, respectively. RCS-03-104-4 causes BRD4 degradation by inducing its proximity with the ubiquitin ligase activity of DCAF11.

DC65682 RCB-4-8 Featured

RCB-4-8 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.1 RCB-4-8-containing LNPs improve lung transfection efficiency by approximately 100-fold over MC3-containing LNPs in mice.

2941228-91-5
DC60505 IR-19-Py(A20-0l) Featured

IR-19-Py(A20-0l) is an ionizable, degradable lipid for nebulized mRNA delivery.

2940240-84-4
DC60506 IR-117-17 Featured

IR-117-17(A10-LIN) is an ionizable, degradable lipid for nebulized mRNA delivery. Nebulized IR-117-17 LNPs produced a 300-fold improvement in lung mRNA delivery over the top previously described LNP. and a two-fold improvement over the previously reported PBAE, including up to a 45-fold improvement in delivery to the large airways.

2940241-38-1
DC65685 BODIPY 581/591 C11 Featured

BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type).

217075-36-0
DC65686 Sotuletinib HCl Featured

Sotuletinib, also known as BLZ945, is a potent and selective CSF-1R kinase inhibitor. BLZ945 showed effects of CSF1R inhibition on other tumor-infiltrating immune cells. BLZ945 attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas. BLZ945 decreases the growth of malignant cells in the mouse mammary tumor virus-driven polyomavirus middle T antigen (MMTV-PyMT) model of mammary carcinogenesis. BLZ945 prevents tumor progression in the keratin 14-expressing human papillomavirus type 16 (K14-HPV-16) transgenic model of cervical carcinogenesis.

2222138-31-8
DC65687 Koenimbine Featured

Koenimbine is an anticancer agent that can be obtained from the leaves and fruits of Murraya koenigii. Koenimbine can induce apoptosis and necrosis in HT-29 and SW48 cells. Koenimbine can be used in the research of cancer.

21087-98-9
DC65688 Perlolyrin Featured

Perlolyrin (Tribulusterine) is an alkaloid that can be isolated from dried fruits of Tribulus terrestris.

29700-20-7
DC65689 PK-10 Featured

PK-10 is a synergistic antibacterial agent of Fluconazole.

DC65690 SKF-91488 HCl Featured

SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a Ki value of 0.9 microM. SKF 91488 dihydrochloride inhibits the methylation of labeled histamine in mice.

68941-21-9
DC65691 CTL-06 Featured

CTL-06 is an inhibitor of Fatty Acid Synthase (FASN).

DC65692 CBiPES HCl Featured

CBiPES hydrochloride is a mGlu2 receptor positive allosteric modulator (EC50: 92.8 nM). CBiPES hydrochloride attenuates stress-induced hyperthermia and PCP-induced hyperlocomotor activity. CBiPES hydrochloride can be used for research of neurological disease.

856702-40-4
DC65693 TZ3O Featured

TZ3O (compound TZ30) is an anticholinergic agent with neuroprotective effects.

2218754-19-7
DC65694 FZD7 antagonist F7H Featured

F7H is a Frizzled receptor FZD7 antagonist (IC50: 1.25 μM). Frizzled receptors (FZDs) influence Wnt signaling, mediating embryonic development and tissue homeostasis. F7H is a potent ligand for the FZD7 transmembrane domain (TMD).

897109-93-2
DC65695 COH1 inhibitor Featured

COH1 is a ribonucleotide reductase (RR) inhibitor. COH1 can be used in research into cancer, mitochondrial diseases, and neurodegenerative diseases.

20217-22-5
DC65696 BML-278 Featured

BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 µM.

120533-76-8
DC60507 CBD3063 Featured

CBD3063 is a selective, first-in-class, CRMP2-based peptidomimetic small molecule, which allosterically regulates Cav2.2 to achieve analgesia and pain relief without negative side effect profiles.

1281060-70-5
DC65697 HDAC6 inhibitor 4510 Featured

A novel and seletive HDAC6 inhibitor.

2758514-39-3
DC65698 4-Methylumbelliferyl a-D-Glucopyranoside Featured

17833-43-1
DC60508 4A3-SCC-10 Featured

4A3-SCC-10 is a biodegradable ionizable lipid with superior endosomal escape and rapid mRNA release ability. In comparison with DLin-MC3-DMA, 4A3-SCC-10-formulated LNPs significantly improve mRNA delivery in livers by 87-fold.

DC60509 4A3-SCC-PH Featured

4A3-SCC-PH is a biodegradable ionizable lipid with superior endosomal escape and rapid mRNA release ability. In comparison with DLin-MC3-DMA, 4A3-SCC-PH-formulated LNPs significantly improve mRNA delivery in livers by 176-fold. 4A3-SCC-PH enhance Fluc mRNA release and luciferase expression in tumor cells, further assisting cancer metastasis delineation and surgical resection.

DC65699 Mal-propyl-Ala-Ala-Asn-PAB Featured

Mal-propyl-Ala-Ala-Asn(Trt)-PAB is a hetero bifunctional cross-linker, useful in antibody drug conjugation (ADC).

2922956-69-0
DC65700 SIALYLGLYCOPEPTIDE Featured

Sialylglycopeptide is a complex N-glycan, bearing a short peptide fragment. Sialylglycopeptide, as a starting material for the semi-synthesis of N-glycans, can be used for various researches.

189035-43-6
DC60598 IAG933 Featured

IAG933 (IAG-933) is a potent, selective and orally efficacious YAP1/WWTR1(TAZ)-panTEAD protein-protein interaction inhibitor (YAP/TAZ-TEADs PPI), inhibits TEAD-driven transcriptional activity and displays anti-cancer effects.

2714434-21-4
DC65702 DFHBI-1T Featured

DFHBI-1T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=472 nm/507 nm). DFHBI-1T binds to RNA aptamers (Spinach, Spinach2, iSpinach, and Broccoli) and causes specific fluorescence and lower background fluorescence. DFHBI-1T is used to image RNA in live cells.

1539318-36-9
DC65703 DFAME Featured

DFAME is a red fluorophore (Ex=508 nm, Em=641 nm). Beetroot and Corn are dimeric fluorogenic RNA aptamers that can bind to DFAME to form Beetroot-DFAME (Kd=460nM) and Corn-DFAME (Kd= 3600nM). Beetroot-DFAME (Kd=460nM) and Corn-DFAME can be used to form RNA assemblies in living cells. Creating RNA assemblies can be used for the study of RNA Nanostructures. DNA/RNA Nanostructures would be useful in cell and gene therapy (CGT) research.

1420815-55-9
DC65701 L-369 Featured

L-369 (Lipid 369,L369) is novel class of ionizable lipid for siRNA delivery with improved in vivo elimination profile with excellent translation across species,including NHP, wide safety margin.

1443522-24-4
DC65704 Mazdutide Featured

Mazdutide (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a glucagon-like peptide-1 (GLP-1R)/glucagon receptor GCGR co-agonist. Mazdutide has safety and tolerability, and it can be used for research in obesity and type 2 diabetes (T2D).

2259884-03-0
DC65705 Cagrilintide Featured

Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity.

1415456-99-3
DC60510 Iso-A11B5C1 Featured

Iso-A11B5C1 is an ionizable lipid. The iso-A11B5C1 LNP demonstrates a high level of muscle-specific mRNA delivery efficiency. exhibiting transfection efficiency comparable to the commercially available lipid SM-102, while considerably reducing inadvertent mRNA expression in main organs such as the liver and spleen.Additionally, study results show that intramuscular administration of mRNA formulated with iso-A11B5C1 LNP caused potent cellular immune responses, even with limited expression observed in lymph nodes.

DC60511 RLY-2608 Featured

RLY-2608 is an oral allosteric pan-mutant isoform-selective PI3K伪 inhibitor that was discovered using MD modeling and cryo-EM to identify allosteric networks and opportunities for small molecules, followed by DEL screening.

2733573-94-7
DC60512 LY3522348 Featured

LY3522348 is a highly selective, oral dual inhibitor of human ketohexokinase isoforms C and A (hKHK-C, hKHK-A). LY3522348 displayed a robust pharmacodynamic response in a mouse model of fructose metabolism and was advanced into clinical trials.

2568608-48-8
DC60513 Pelcitoclax Featured

Pelcitoclax, also known as APG 1252 and BM1251, is a potent and selective Bcl-2/Bcl-XL inhibitor. APG-1252 A Bcl-2 homology (BH)-3 mimetic and selective inhibitor of the anti-apoptotic proteins B-cell lymphoma 2 (Bcl-2) and Bcl-XL, with potential pro-apoptotic and antineoplastic activities. Upon administration, Bcl-2/Bcl-XL inhibitor APG-1252 specifically binds to and inhibits the activity of the pro-survival proteins Bcl-2 and Bcl-XL. This restores apoptotic processes and inhibits cell proliferation in Bcl-2/Bcl-XL-dependent tumor cells.

1619923-36-2
DC60514 AM-2-19 (SF001) Featured

AM-2-19 (SF001) is an ergosterol-extracting polyene antifungal that is discovered through modifications to the amphotericin B toxin by chemists.

2761794-74-3
DC60515 INX-315 Featured

INX-315 is a novel and potent CDK2 inhibitor with IC50 of 2.3 nM and shows high selectivity over other CDK family members (374 nM against CDK1/cyclin and 950 nM against CDK9/cyclin,respectively). INX-315 promotes retinoblastoma protein hypo-phosphorylation and therapy-induced senescence (TIS) in CCNE1-amplified tumors, overcomes breast cancer resistance to CDK4/6i and delays the onset of CDK4/6i resistance in breast cancer.

2745060-92-6
DC60516 TRIM-473 Featured

TRIM-473 is a novel ligand for the PRY-SPRY domain of the E3 RING ligase TRIM58 with EC50 of 5.3 μM.

DC60517 Compoud 18 (AEP inhibitor) Featured

Compoud 18 (AEP inhibitor) is first orthosteric, selective, orally bioavailable, and brain penetrant inhibitor with IC50 of 7.8 nM against asparagine endopeptidase (AEP) with an irreversible binding mode.

DC60518 ACBI3 Featured

ACBI3 is a selective, potent and in vivo active pan-KRAS PROTAC degrader, potently degrades 13 out of 17 of the most prevalent oncogenic KRAS alleles (DC50=3.9 nM in GP2d cells).

2938169-76-5
DC60519 ABBV-467 Featured

 ABBV-467 is a selective MCL-1 inhibitor. In vivo, intermittent dosing of ABBV-467 as monotherapy or in combination with venetoclax inhibits the growth of xenografts from human hematologic cancers.

2287186-66-5
DC60520 BMS-502(SCHEMBL21830991) Featured

BMS-502 is a dual DGKα and ζ inhibitor. BMS-502 demonstrated dose-dependent immune stimulation in the mouse OT-1 model, setting the stage for a drug discovery program.

2407854-18-4
DC60521 pociredir Featured

Pociredir is an embryonic ectoderm development (EED) protein inhibitor. Pociredir can be used for the research of inflammatory or hemoglobinopathies, such as sickle cell disease.

2490674-02-5
DC60522 TP0472993 Featured

TP0472993 is an oral 20-hydroxyeicosatetraenoic acid synthesis inhibitor

2126874-77-7
DC60523 CT-3 Featured

CT-3 is an irreversible trypanosomal topo. II inhibitor.

2403729-27-9
DC60524 GNE-7883 Featured

 GNE-7883 is a pan-TEAD inhibitor.

2648450-42-2
DC60525 KCL-286 Featured

KCL-286 is an oral RARβ agonist.

1952276-71-9
DC60526 AEF 0117 Featured

AEF0117 is a Signaling-specific CB1 inhibitor.

1610878-71-1
DC60527 LUNA18 Featured

LUNA18 is an 11-mer cyclic peptide inhibitor for the intracellular tough target RAS with Kd (KRAS/G12D) of 0.043 nM and cellular IC50 of 1.4 nM (AsPC-1). LUNA18 orally and dose-dependently exhibits potent anti-cancer activities in a mouse xenograft model. LUNA18 shows 21–47% oral bioavailability in animals such as mouse, rat, monkey, and dog and notably does not require special formulations.

2676177-63-0
DC60528 DNL343 Featured

DNL343 is a potent, selective, and brain-penetrant eukaryotic translation initiation factor 2B (eIF2B) activator with ATF4 IC50 of 9.8 nM.

2278265-85-1
DC60529 LY3473329 (Muvalaplin) Featured

LY3473329 (Muvalaplin) is a potent, multivalent disruptor of lipoprotein(a) (Lp(a)). LY3473329-HCl binds to apolipoprotein KIV8 selectively with a potency of 22 nM and inhibits the formation of Lp(a) particles in vitro with IC50 of 0.09 nM.

2565656-70-2
DC60530 BTK-IN-24(NX-5948) Featured

NX-5948,be also known as BTK-IN-24,is an oral BTK degrader.

2649400-34-8
DC60531 VX-548(Suzetrigine) Featured

Suzetrigine is a SCN10A blocker. The SCN10A is associated with the onset of pain due to peripheral neuropathy. Suzetrigine functions as an analgesic.

2649467-58-1
DC60532 BMS-986172 Featured

BMS-986172 is a highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a L BMS-986172 showed on-target- and mechanism-based pharmacology. Moreover, its favorable pharmacokinetic (PK) profile and the lack of species variability in the glucuronidation potential resulted in a greater confidence level in the projection of a low dose for achieving targeted efficacious exposures in humans. Consistent with these projections.

1808258-99-2
DC60533 Encaleret Featured

Encaleret, also known as JIT-305, is an oral calcium-sensing receptor (CaSR) antagonist, for the treatment of osteoporosis.

787583-71-5
DC60534 PF-07202954 Featured

PF-07202954 is a DGAT2 Inhibitor (IC50 = 10 nM) with Longer Predicted Half-Life.

2639372-47-5
DC60535 NT-0796 Featured

NT-0796 is a Brain-Penetrant and Highly Potent. NLRP3 Inflammasome Inhibitor (IC50 = 0.32 nM) for Neuroinflammatory Disorders.

2272917-13-0
DC65706 STM3006 Featured

STM3006 is a highly potent, selective and orally active METTL3 inhibitor. STM3006 can be used for the research of acute myeloid leukaemia (AML).

2499664-52-5
DC60536 Zosurabalpin (RG6006) Featured

Zosurabalpin (RG6006) is a class of tethered macrocyclic peptide (MCP) antibiotic. Zosurabalpin (RG6006), effectively treats highly drug-resistant contemporary isolates of CRAB (carbapenem-resistant acinetobacter baumannii) both in vitro and in mouse models of infection, overcoming existing antibiotic resistance mechanisms.

2379336-76-0
DC60537 NC-TNP Featured

NC-TNP (noncationic thiourea lipids nanoparticles) could compress mRNA by strong hydrogen bonds interaction between thiourea groups of NC-TNP and the phosphate groups of mRNA. NC-TNP could escape the recycling pathway to inhibit the egress of internalized nanoparticles from the intracellular compartment to the extracellular milieu. NC-TNP-encapsulated mRNA shows higher gene transfection efficiency in vitro and in vivo than mRNA-LNP formulation. NC-TNP also shows spleen targeting delivery ability with higher accumulation ratio (spleen/liver), compared with traditional LNP.

DC60538 TAK-994 Featured

TAK-994 is an oral, selective OX2R agonist developed by Takeda for the treatment of narcolepsy type 1 (with cataplexy) and type 2 (without cataplexy). The molecule follows Takeda’s previous clinical molecule, TAK-925 (danavorexton), which was the first OX2R agonist to be tested in people with NT1 but had poor oral bioavailability and was administered intravenously in the clinic.

2861934-86-1
DC60539 RAS Inhibitor A122 Featured

RAS Inhibitor A122 - This oral tri-complex RAS(MULTI)(ON) inhibitor is a relative from a patent application of the currently undisclosed RMC-6236, which is currently in Phase I/Ib clinical trials for solid tumors. The RAS(MULTI) series was identified via SBDD based on extensive knowledge of RAS tricomplex inhibitors such as G12C tricomplex inhibitor, RMC-6291.

DC60540 KIO-301 Featured

KIO-301 – A photoswitchable HCN channel blocker with positive initial results from a Phase I/II for retinitis pigmentosa and choroideremia study that is being developed by KIORA Therapeutics.

1643463-61-9
DC65707 Thiophene, 2-methyl-5-(phenylsulfonyl)- Featured

5324-81-2
DC65708 3-Methyl-5-(methylsulfamoyl)thiophene-2-carboxylic acid Featured

1096800-92-8
DC65709 PS-13 precursor 19 Featured

PS-13 precursor 19 is the precursor of PS-13. PS13 is a highly potent COX-1 inhibitor (IC50=1 nM) and 1,000 times more selective for COX-1 than COX-2 (7).

726196-75-4
DC65710 PS13 Featured

PS13 is a highly potent COX-1 inhibitor (IC50=1 nM) and 1,000 times more selective for COX-1 than COX-2 (7). In non-human primates, 11C-PS13 showed selective binding to COX-1 over COX-2 in most major organs including the spleen, gastrointestinal tract, kidneys, and brain.

524699-85-2
DC65711 SK-575 Featured

SK-575 is a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations and induces potent and specific degradation of PARP1 in various human cancer cells even at low picomolar concentrations. SK-575 achieves durable tumor growth inhibition in mice when used as a single agent or in combination with cytotoxic agents, such as temozolomide and cisplatin.

2523016-96-6
DC60542 NP3-562 Featured

NP3-562 is a potent, orally bioavailable, tricyclic NLRP3 inhibitor with IC50 of 0.26 μM in the FP binding assay. NP3-562 demonstrates excellent potency in human whole blood and full inhibition of IL-1β release in a mouse acute peritonitis model.

DC65712 TL 13-27 Featured

TL 13-27 is a negative control for TL 12-186. Demonstrates no kinase degradation in vitro.

2250025-90-0
DC65713 mPEG-5000-DSPE, Na Featured

DSPE-MPEG(5000) is a PEGylated form of 1,2-distearoyl-rac-glycero-3-PE (DSPE). It has been used in the synthesis of lipid nanoparticles (LNPs) and liposomes for in vitro and in vivo two-photon bioimaging.

147867-65-0
DC90033 RGT1383 Featured

RGT1383 is a novel GLP-1R agonist, an analog of PF-06882961.

2428641-93-2
DC90070 (-)-tetrabenazine Featured

Inhibitor of VMAT-2, decreasing monamines into synaptic vesicles

1026016-84-1
DCC0270 5-alpha-hydroxy-laxogenin Featured

5-alpha-hydroxy-laxogenin is a derivative of the spirostane-type steroid, laxogenin. 5α-Hydroxy-laxogenin can be used as a plant-based anabolic agent as a dietary supplement.

56786-63-1
DCC0281 5-ht3 Antagonist-4i Featured

5-HT3 antagonist 4 is a 5-HT3 receptor (5HT3R) antagonist. 5-HT3 antagonist 4 prevents diabetes-induced depressive phenotypes in mice.

930478-88-9
DCC0466 Adamts-5 Inhibitor Featured

Selective inhibitor of ADAMTS-5 (A disintegrin and metalloproteinase with thrombospondin motifs 5 or aggrecanase-2)

929634-33-3
DCC0543 Alk-001 Featured

ALK-001 is a vitamin A analog potentially for the treatment of Stargardt’s disease.

118139-36-9
DCC0545 Alkyne-a-dsbso Featured

Novel Enrichable and MS-Cleavable Cross-linker to Define Protein-Protein Interactions by Mass Spectrometry

1704097-05-1
DCC0593 Sotorasib racemate Featured

Sotorasib racemate (Compound A) is an orally active racemate of Sotorasib, a covalent inhibitor of KRAS G12C mutant which induces adaptive feedback activation of MAPK pathway. Sotorasib racemate also exerts inhibitor activity against KRAS G12C induced cancer and can be applied to cancer research.

2252403-56-6
DCC0661 Ap1510 Featured

AP1510 is a potent cell-permeable ligand for human FKBP12. AP1510 regulates protein-protein interactions through dimerization.

178446-42-9
DCC0768 aTAG 4531 Featured

aTAG 4531 (CFT-4531) is a potent, selective, and onmechanism tool degrader of MTH1 with DC50 value of 0.28 nM and Ki value of 1.8 nM. degradation activity is due to the intricate formation of the ternary complex between the MTH1 aTAG, CRBN E3 ligase, and aTAG tool degrader .

2412985-00-1
DCC0844 Azd1897 Featured

AZD1897 is a PIM1, PIM2, and PIM3 inhibitor with IC50 values of less than 3 nM for these three PIM kinases. AZD1897 exhibits anticancer activity and synergistically inhibits the activity of acute myeloid leukemia (AML) cells in combination with Capivasertib (HY-15431). This synergistic inhibitory effect is achieved through the inhibition of the mTOR and MCL1 pathways.

1204181-93-0
DCC0857 Azide-a-dsbso Featured

Azide-A-DSBSO crosslinker is a mass spectrometry (MS)-cleavable, membrane-permeable, homobifunctional, azide-labeled, acid-cleavable cross-linked peptide. Azide-A-DSBSO crosslinker enables the study of protein-protein interactions via cross-linking mass spectrometry (XL-MS).

1704097-02-8
DCC0907 Bb-83698 Featured

BB-83698 is a peptide deformylase inhibitor and potent antimicrobial with excellent activity against streptococci and Moraxella catarrhalis strains.

325795-25-3
DC90961 Bff-816 Featured

Novel, systemically active kynurenine aminotransferase 2 (KAT2) inhibitor, significantly decreased escape latency in the Morris water maze, indicating improved performance in spatial and contextual memorynovel

2008006-36-6
DCC1048 Bms184394 Featured

Novel selective inhibitor of RARγ

DCC1108 Bpn-14136 Featured

Novel RBP4 antagonist with good in vitro potency and selectivity and optimal rodent pharmacokinetic (PK) and pharmacodynamic (PD) characteristics

1628945-93-6
DCC1169 Bulgecin A Featured

Bulgecin A is an inhibitor of binuclear metallo-beta-lactamases and Lytic transglycosolase.

92953-54-3
DCC1203 Calcein-am Featured

Cell permeable derivative of calcein, becoming fluorescent on hydrolysis

148504-34-1
DCC1281 (E/Z)-CCR-11 Featured

(E/Z)-CCR-11 (Comp 12) is a selective CD38 inhibitor, with an IC50 of 20.8 μM against CD38 cyclase. (E/Z)-CCR-11 promotes increases in cellular NAD+ levels and interferon γ.

301687-87-6
DCC1351 Cga-jk3 Featured

CGA-JK3 is CGA-JK3 is an ATP-competitive inhibitor of IKKβ-catalyzed kinase activity. CGA-JK3 inhibits IκBα phosphorylation in LPS (HY-D1056) - induced RAW 264.7 cells.

1621626-06-9
DCC1618 Cyanotryptophan Featured

Blue fluorescent amino acid, exhibiting blue fluorescence (λ max ~ 405 nm) with a high quantum yield and long lifetime

1132749-42-8
DCC1706 Dd04107 Featured

Novel inhibitor of α-calcitonin gene-related peptide (α-CGRP) exocytotic release from primary sensory neurons, selectively interacting with Synaptotagmin 1

1202877-06-2
DCC1779 Did Perchlorate Featured

Lipophilic fluorescent reagent, labeling membranes and other hydrophobic structures

127274-91-3
DCC1837 Dolastatin 10 Featured

Highly potent cytotoxic microtubule inhibitor

110417-88-4
DCC1870 Dsm502 Featured

Novel potent inhibitor of dihydroorotate dehydrogenase (DHODH)

2426616-55-7
DCC1968 Entasobulin Featured

Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity.

501921-61-5
DCC2205 Gac0001e5 Featured

GAC0003A4 is an LXR inverse agonist that inhibits LXR transcriptional activity. GAC0003A4 also efficiently degrades LXRβ protein. GAC0003A4 has the potential to be used in advanced pancreatic cancer and other refractory malignancies.

929492-71-7
DCC2206 Gac0003a4 Featured

Novel LXR inverse agonist, functioning as LXR a degrader, significantly reducing LXR protein levels in PDAC cell lines

927969-67-3
DCC2242 GFB-12811 Featured

GFB-12811 is a high selective and orally active CDK5 inhibitor with an IC50 of 2.3 nM. GFB-12811 is highly selective over the other tested kinases (CDK1/2/6/7/9).

2775311-17-4
DCC2251 Gilteritinib Fumarate Featured

Gilteritinib (ASP2215) hemifumarate is a potent and ATP-competitive FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively.

1254053-84-3
DCC2356 Gsk1733953a Featured

Novel Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG

930470-97-6
DCC2390 Gsk3-in-38 Featured

GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy. GSK3-IN-3 is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDA.

331963-27-0
DCC2512 Hdl376 Featured

HDL376 is a scavenger receptor class B type I (SR-BI) inhibitor. HDL376 directly inhibits SR-BI-mediated lipid transport in cells and in liposomes reconstituted with purified SR-BI (IC50 = 0.22 μM). HDL376 can be used for the research of atherosclerotic coronary artery disease.

147751-31-3
DCC2842 JNJ-40355003 Featured

JNJ-40355003 is a potent and selective atty acid amide hydrolase (FAAH) inhibitor.

1394894-41-7
DCC3008 L-778123 Featured

L-778123 is a dual FPTase and GGPTase-I inhibitor, with IC50s of 2 nM and 98 nM respectively.

183499-57-2
DCC3108 Lk-514 Featured

Novel selective agonist of the human melanocortin 1 receptor (hMC1R) for sunless tanning and prevention of genotoxicity of UV in melanocytes

DCC3120 Lobeglitazone Sulfate Featured

Peroxisome proliferator-activated receptor-α/γ (PPAR α/γ) dual agonist

763108-62-9
DCC3204 M4k2009 Featured

M4K2209 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 9 nM, >180-fold selective over ALK5 (IC50=2427 nM).

2600795-07-9
DCC3234 Maropitant Citrate [359875-09-5] Featured

Neurokinin receptor antagonist with antiemetic activity

359875-09-5
DCC3263 MCC950 free acid Featured

Potent and selective inhibitor of NLRP3, reducing interleukin-1β (IL-1β) production in vivo and attenuating the severity of experimental autoimmune encephalomyelitis (EAE)

210826-40-7
DCC3273 Mcmmad Featured

Novel mc (maleimidocaproyl) linker plus MMAD (Monomethylauristatin D) to be used for prepare antibodies conjugates via cysteine-capped mechanism

1401963-15-2
DCC3294 Mebeverine Hydrochloride Featured

Second generation papaverine analog, acting as an anticholinergic agent

2753-45-9
DCC3322 Methylaervine Featured

Natural antifungal agent, significantly inducing lipid peroxidation, activating the antioxidant enzymes, and exhibiting effective activity against F. solani (EC50 = 10.56 µM)

86293-40-5
DC3333 mG2N001 Featured

mG2N001 is a potent negative allosteric modulator (NAM) of metabotropic glutamate receptor 2 (mGluR2) with IC50 of 93 nM.

DCC3449 Momelotinib Dihydrochloride Featured

Momelotinib (dihydrochloride) is a JAK1/JAK2 inhibitor that also antagonizes ACVR1, leading to downregulation of Hepcidin expression and increased availability of iron for erythropoiesis. Momelotinib (dihydrochloride) can reduce transfusion burden and spleen enlargement caused by myelofibrosis, showing potential value in research and application within the field of myelofibrosis.

1380317-28-1
DCC3720 Nrf2-activator Featured

Nrf2-Activator is a potent Nrf-2 activator.

1554271-18-9
DCC3870 Obtusilactone B Featured

Specific inhibitor of vaccinia-related kinase 1 (VRK1)-mediated phosphorylation of barrier-to-autointegration factor (BAF)

58940-66-2
DCC3875 Octreotideacetate GMP grade Featured

Agonist of sst2, sst3 and sst5 somatostatin receptors

83150-76-9
DCC3952 Oxiperomide Featured

Dual dopamine D2 and muscarinic M1 receptor ligand with putative antipsychotic and pro-cognitive potential

5322-53-2
DCC3965 P-2281 Featured

Novel potent inhibitor of mTOR activity, significantly suppressing macroscopic and histologic abnormalities associated with chemically-induced murine ulcerative colitis.

1112994-35-0
DCC3985 Palbociclib Dihydrochloride Featured

Selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6

571189-11-2
DCC4088 Pf-06424439 Mesylate Featured

Potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2)

1469284-79-4
DC30002 PF-06835919 Featured

PF-06835919, also known as MDK1846, is a potent ketohexokinase (KHK) inhibitor. PF-06835919 is reported in patent US 20170183328 A1, example 4. Increased fructose consumption and its subsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin resistance in humans. Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, identification of a selective KHK inhibitor may help to further elucidate the effect of KHK inhibition on these metabolic disorders.

2102501-84-6
DCC4102 Pf-543 Hydrochloride Featured

Novel, potent and specific inhibitor of sphingosine kinase-1 (SphK1)

1706522-79-3
DCC4236 Pradigastat Featured

Pradigastat (LCQ-908) is a potent, selective and orally active diacylglycerol acyltransferase 1 (DGAT1) inhibitor. Pradigastat has anti-obesity and anti-diabetic effects.

956136-95-1
DCC4245 Prmt5-in-c17 Featured

Novel potent, selective, and cell active protein arginine methyltransferase 5 (PRMT5) inhibitor

330951-01-4
DCC4275 Prx-08066 Maleate Featured

Novel potent and selective 5-HT2B receptor antagonist

866206-55-5
DCC4285 Psb-1434 Featured

Highly potent, selective, competitive, and reversible inhibitor of monoamine oxidase B (MAO-B)

1619884-65-9
DCC4286 Psb-1491 Featured

Highly potent, selective, competitive, and reversible inhibitor of monoamine oxidase B (MAO-B)

1619884-67-1
DCC4365 Rac-nbi-74330 Featured

rac-NBI-74330 is a potent and selective CXCR3 antagonist.

473722-68-8
DCC4502 Rs-25344 Featured

Selective phosphodiesterase-4 (PDE4) inhibitor

152814-89-6
DCC4907 Ssr180575 Featured

SSR-180,575 is a drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO. It has been shown to have neuroprotective and cardioprotective effects and to stimulate steroidogenesis of pregnenolone in the brain, which may be linked to its neuroprotective action.

220448-02-2
DCC5054 FPR Agonist 43 Featured

FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist.

903895-98-7
DCC5080 Tecovirimat Hydrate Featured

Novel inhibitor of viral p37, blocking the ability of virus particles to be released from infected cells, being used for the treatment of smallpox, monkeypox, orthopoxvirus, and orthopoxviral Disease.

1162664-19-8
DCC5325 Unc0737 Featured

UNC0737 is a negative control of UNC0638 and the N-methyl analog of UNC0638. UNC0737 was designed to eliminate the hydrogen bond interaction seen in the G9a-UNC0224 cocrystal structure between Asp1083 of G9a and the secondary amino group at the 4-position of UNC0224's quinazoline ring3. UNC0737 was >300-fold less potent than UNC0638 in G9a and GLP biochemical assays. As expected, UNC0737 was a poor inhibitor of G9a (IC50 = 5,000 ± 200 nM (n = 2)) and GLP (IC50 > 10,000 nM (n = 2)) in the SAHH-coupled assays.

1327276-39-0
DCC5343 Unipr500 Featured

Novel Eph antagonist, inhibiting Eph/ephrin interactions, enhancing glucose-stimulated insulin secretion (GSIS), and acting as a hypoglycemic agent

DCC5423 Setmelanotide Tfa Salt Featured

Novel highly-selective melanocortin-4 receptor (MC4R) agonist, increasing resting energy expenditure in obese individuals

920014-72-8
DCC5447 Vu0366248 Featured

VU0366248 is a mGlu5 negative allosteric modulator.

1243310-20-4
DCC5479 Vuf10497 Featured

VUF10497 is a potent histamine H4 receptor (H4R) inverse agonist with anti-inflammatory activity.

1080623-12-6
DCC5498 Biricodar(Vx-710) Featured

Biricodar (VX-710) is a modulator of P-glycoprotein and MRP-1; shows effective chemosensitizing activity in multidrug resistant cells.

159997-94-1
DCC5500 w-13 Hydrochloride Featured

W-13 hydrochloride is a calmodulin antagonist. W-13 hydrochloride can inhibit Tamoxifen (HY-13757A)-resistant human breast cancer cell growth.

88519-57-7
DCC5576 Ym-244769 Featured

YM-244769 is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC50s of 18 nM and 50 nM, respectively. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 can also increase urine volume and urinary excretion of electrolytes in mice.

838819-70-8
DCC5670 Zxh-1-161 Featured

Novel Selective Degrader of GSPT1

2407654-51-5
DC65714 Filanesib hydrochloride Featured

Filanesib (ARRY-520) hydrochloride is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity.

1385020-40-5
DC65715 VU0364739 Featured

VU0364739 is a selective PLD2 inhibitor (IC50: 22 nM). VU0364739 decreases cancer cell proliferation.

1244640-48-9
DC65716 RMC6236 Featured

RMC-6236 (Compound A122) is a potent RAS(ON)MULTI inhibitor and can be used for the research of cancer.

2765081-21-6
DC65717 DPPE Featured

DPPE is a derivative of phosphatidylethanolamine with (16:0) palmitoyl acyl chains

923-61-5
DC65718 DMPE Featured

DMPE is derivative of phosphatidylethanolamine with (14:0) myristic acid acyl chains.

998-07-2
DC65719 mPEG-DMG, MW 5,000 Featured

mPEG-DMG, MW 5,000 is a large PEG lipid containing a DMG group and a methoxy cap. The methoxy cap is inert while the DMG group is a popular ligand for developing PEG-lipids and lipid nanoparticles more broadly. Varying the size of a PEG linker greatly impacts its molecular dynamics, thereby affecting DMPK and ADME properties of a given API.

DC65720 Bis(linoleyl) ketone Featured

1169768-30-2
DC65721 1,2(R)-Dioleyloxy-sn-giycero-3-phosphocholine Featured

145849-25-7
DC65722 1,2-Dioleyloxy-sn-giycero-3-phosphocholine Featured

1068-79-0
DC65723 1-Palmitoyl-sn-glycero-3-phosphocholine Featured

1-Palmitoyl-sn-glycero-3-phosphocholine is an abundant gonadal LPC (lysophosphatidylcholine).

17364-16-8
DC65724 1-Stearoyl-sn-glycero-3-phosphocholine Featured

1-Stearoyl-sn-glycero-3-phosphocholine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

19420-57-6
DC65725 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC Featured

1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers.

26853-31-6
DC65726 DPPE-cap-Biotine Featured

384835-52-3
DC65727 DMPG Featured

DMPG is a phospholipid containing the saturated long-chain (14:0) myristic acid.

200880-40-6
DC65728 DSPA Featured

DSPA is a form of phosphatidic acid (PA) containing a phosphatidic acid head group and 18:0 fatty acids

108321-18-2
DC65729 DOPG-Na Featured

DOPG-Na is a phospholipid containing the long-chain (18:1) fatty acid oleic acid inserted at the sn-1 and sn-2 positions. It can be used in the generation of micelles, liposomes, and other artificial membranes. DOPG is an anionic phospholipid derivative. The negatively charged liposomes prepared with DOPG has been found to possess the best loading capacity and encapsulation rate for Peptide Nucleic Acid (PNA) oligomers.

67254-28-8
DC65730 DPhPC Featured

DPhPC is a phospholipid used to synthesize bilayer vesicles. DPhPC bilayers do not permit ions to leak in the absence of a pore/ion channel, which can be used for studies on channel proteins.

207131-40-6
DC65731 DPPA Featured

DPPA is a form of phosphatidic acid (PA).

169051-60-9
DC65732 1,2-dipalmitoyl-3-succinylglycerol Featured

108032-13-9
DC65733 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium salt Featured

321595-13-5
DC65735 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Featured

253685-27-7
DC65736 1,2-Dilauroyl-sn-giycero-3-phospho-l-serine sodium-salt Featured

208757-51-1
DC65737 1,2-Dimyristoyl-sn-giycero-3-phospho-l-serine (Na salt) Featured

105405-50-3
DC65738 1-Stearoyl-2-oleoyl-sn-glycero-3-PC Featured

2-Oleoyl-1-stearoyl-sn-glycero-3-phosphocholine (1-Stearoyl-2-oleoyl-sn-glycero-3-PC) is an active compound. 2-Oleoyl-1-stearoyl-sn-glycero-3-phosphocholine can be used for various biochemical studies.

56421-10-4
DC65739 18:0-18:2 PE Featured

18:0-18:2 PE is a lipid for agents delivering. 18:0-18:2 PE is mainly composed of unsaturated fatty acids. 18:0-18:2 is considered important precursors of important odorants (IOs) in Eriocheir sinensis.

7266-53-7
DC65740 1-Stearoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine sodium Featured

1-Stearoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine sodium is a glycerophospholipid.

322647-11-0
DC65741 1,2-Dipalmitoyl-sn-giycero-3-phosphoethanolamine-N-[3-(2-pyridyldithio)propionate](sodiuM salt) Featured

474944-16-6
DC60543 DIM1 Featured

DIM1 is a sugar-alcohol-derived ionizable lipid with mannitol as the precursor. DIM1T is an optimal LNP formulation for potent mRNA delivery in adipose stem cells (ASCs). Importantly, DIM1T LNPs demonstrated considerably higher mRNA delivery efficiency than MC3, ALC-0315, and SM102. The DIM1T LNP-SEC engineered ASCs (DS-ASCs) prolong expression of hepatocyte growth factor (HGF) and C-X-C motif chemokine ligand 12 (CXCL12), which show superior wound healing efficacy over their wild-type and DIM1T LNP-mRNA counterparts in the diabetic cutaneous wound model.

DC60544 CBI1 Featured

CBI1 (covalent BAX inhibitor 1) is a compound that selectively derivatizes BAX at C126 with BME50 value of 905 μM. CBI1 inhibits BAX activation by triggering ligands or point mutagenesis.

DC65742 (s)-1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Featured

71357-99-8
DC65743 1,2-O-Dioctadecyl-sn-glycerol Featured

82188-61-2
DC65744 1,2-Dioleoyl-sn-glycero-3-phosphocholine Featured

37070-48-7
DC65745 POPE Featured

POPE is a phospholipid, and can be used for drug delivery.

26662-94-2
DC65746 1,2-dieicosanoyl-sn-glycero-3-phosphocholine Featured

61596-53-0
DC65747 1,2-Dioleoyl-3-palmitoyl-rac-glycerol Featured

65390-75-2
DC65748 1,2-Dibutyryl-sn-glycero-3-phosphocholine Featured

3355-26-8
DC65749 18:1 DGS 1,2-Dioleoyl-sn-glycerol-3-succinate Featured

127640-49-7
DC65750 1,2-dioctanoyl-sn-glycero-3-phosphate acid (sodium salt) Featured

321883-54-9
DC65751 L-Dilinoleoyllecithin Featured

L-Dilinoleoyllecithin is a phosphatidylcholine (PC or GPCho). It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphocholines can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PC(18:2(9Z,12Z)/18:2(9Z,12Z)), in particular, consists of two chains of linoleic acid at the C-1 and C-2 positions. The linoleic acid moieties are derived from seed oils. Phospholipids, are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling.While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. PCs can be synthesized via three different routes. In one route, choline is activated first by phosphorylation and then by coupling to CDP prior to attachment to phosphatidic acid. PCs can also synthesized by the addition of choline to CDP-activated 1,2-diacylglycerol. A third route to PC synthesis involves the conversion of either PS or PE to PC.

998-06-1
DC65752 1,2-Dihexadecyl-sn-glycero-3-phosphoethanolamine Featured

61423-61-8
DC65753 DOTAP Mesylate Featured

DOTAP mesylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

252769-92-9
DC65754 DSG Featured

1429-59-0
DC65756 Trilinolein Featured

Trilinolein is an endogenous metabolite.

537-40-6
DC65757 AOP Featured

156311-85-2
DC65758 Methoxypoly(ethylene glycol)propionitrile(mPEG-CN) Featured

DC65759 Methoxypoly(ethylene glycol)Giycerol(mPEG-GLC) Featured

DC65760 Methoxypoly(ethylene glycol)Epoxide(mPEG-epoxide) Featured

DC65761 DMG-mPEG2000(酯型) Featured

DC65762 Polyethylene glycol[PEG]dimyristoyl glycerol Epoxide Featured

DC65763 MPEG-GLC Featured

DC65764 14:0 PEG2000 PE Featured

14:0 PEG2000 PE (DMPE-PEG2000) is a PEG-phospholipid conjugate to prepare nanostructured lipid carrier.

474922-82-2
DC65765 mPEG2000-CH2CH2CN Featured

DC65766 mPEG2000-NPC Featured

DC65767 2-(2-(2-Aminoethoxy)ethoxy)acetic acid hydrochloride Featured

134979-01-4
DC65768 (R)-3-((4-methoxybenzyl)propane-1,2-diol Featured

109786-74-5
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