| DC20838 |
BRD0705
Featured
|
BRD0705 is a potent, paralog-selective GSK3α inhibitor with IC50 of 66 nM, 8-fold selectivity over GSK3β (IC50=515 nM). |
|
| DC20831 |
BRD2492
Featured
|
BRD2492 is a highly potent, selective HDAC1/2 inhibitor (IC50=2/19 nM, respectively) that displays excellent selectivity versus HDAC3 (IC50=2.08 uM, ≥110-fold selectivity) and all other HDAC isoforms, increases caspase-3 activation.. |
|
| DC20832 |
BRD3308
Featured
|
BRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM, displays >20-fold selectivity over HDAC1 and HDAC2, >500-fold selectivity over other HDAC isoforms. |
|
| DC7674 |
BRD4770
Featured
|
BRD4770 is a selective inhibitor of the histone methyltransferase G9a. |
|
| DC22711 |
BRD5814
Featured
|
BRD5814 is a potent, selective, highly brain penetrant β-arrestin biased dopamine D2 receptor (D2R) antagonist with Ki of 0.27 uM. |
|
| DC8446 |
BRD7116
Featured
|
BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity. |
|
| DC7936 |
BRD73954
Featured
|
BRD-73954 is a biochemical inhibitor histone deacetylase cancer histone modification epigenetics gene regulation small molecule HDAC6 HDAC8. |
|
| DC8409 |
BRD7552
Featured
|
BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. |
|
| DC20981 |
Brequinar sodium
Featured
|
Brequinar sodium (DuP-785, Brequinar, NSC 368390) is a potent and selective inhibitor of DHODH with IC50 of 20 nM, triggers differentiation in the ER-HoxA9, U937, and THP1 cells with an ED50 of 1 uM. |
|
| DC10605 |
Brevianamide F
Featured
|
Brevianamide F , also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines. |
|
| DC8286 |
Brexpiprazole(OPC34712)
Featured
|
Brexpiprazole is a novel D2 dopamine partial agonist. |
|
| DC8179 |
Briciclib(ON 013105,ON 014185)
Featured
|
Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells. |
|
| DC23147 |
Brigatinib (AP-26113)
Featured
|
Brigatinib (AP-26113, AP26113) is a potent, selective, second generation ALK inhibitor with IC50 of 0.62 nM, exhibits about fivefold greater potency in vitro compared with crizotinib. |
|
| DC2019 |
Brivanib (bms-540215)
Featured
|
Brivanib is an ATP-competitive inhibitor against human VEGFR2 and FGFR with IC50 of 25 nM and 148 nM, respectively. |
|
| DC9535 |
Brivaracetam
Featured
|
Brivaracetam(UCB-34714) is a 4-substituted pyrrolidone butanamide as agent with significant antiepileptic activity; high affinity SV2A ligand and also shows an ability to inhibit Na+ channels.
|
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|
| DC20180 |
BRL-50481
Featured
|
BRL-50481 is a novel and selective inhibitor of phosphodiesterase (PDE) 7 with a Ki value, derived from secondary (Dixon) plots, of 180±10 nM, being at least 200-fold selective for hrPDE7A1 over all other PDEs. |
|
| DC23899 |
Bromocriptine mesylate
Featured
|
Bromocriptine (CB-154) is a dopamine D2 receptor agonist (Ki=3 nM) and and various serotonin receptors, also inhibits the release of glutamate by reversing the glutamate GLT1 transporter. |
|
| DC8386 |
Bromodeoxyuridine (BrdU)
Featured
|
Bromodeoxyuridine (BrdU) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells. |
|
| DC7543 |
Bromosporine
Featured
|
Bromosporine is a broad spectrum bromodomain inhibitor. Accelerates FRAP recovery of BRD4 and CREBBP in cells at a concentration of 1 μM. |
|
| DC11038 |
Bryostatin 1
Featured
|
Bryostatin 1 (NSC 339555) is a macrocyclic lactone derived from a marine invertebrate, fuctions as an activator of PKC with high binding affinity (Ki=1.35 nM). |
|
| DC9846 |
BS-181
Featured
|
BS-181 is a highly selective CDK7 inhibitor with IC50 of 21 nM. ; >40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. |
|
| DC8101 |
BS-181 hydrochloride
Featured
|
BS-181 is a highly selective CDK7 inhibitor with IC50 of 21 nM. ; >40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. |
|
| DC8517 |
BS194
Featured
|
BS-194 is a selective and potent CDK inhibitor, which inhibits CDK2, CDK1, CDK5, CDK7, and CDK9 with IC50 values of 3, 30, 30, 250, and 90 nM respectively. |
|
| DC12380 |
BSJ-03-123
Featured
|
BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions. |
|
| DC10460 |
BT-11
Featured
|
BT-11 is an orally active and selective LANCL2 modulator. |
|
| DC10164 |
BTB-1
Featured
|
BTB-1 is a small molecule inhibitor of the mitotic motor protein Kif18A. |
|
| DC20199 |
BTK inhibitor 1;Compound 27
Featured
|
BTK inhibitor 1 (Compound 27) |
|
| DC23413 |
BTRX335140
Featured
|
BTRX-335140 (CYM-53093, BTRX335140, CYM53093) is a potent, selective, orally active κ opioid receptor (KOR) antagonist with IC50 of 0.8 nM. |
|
| DC12456 |
BTT-266
Featured
|
BTT-266 (BTT266) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction, directly binds to CaVβ3 with Kd of 3.6 uM. |
|
| DC23703 |
BTYNB
Featured
|
BTYNB is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA with IC50 of 5 uM. |
|
