Home > Products > Featured products
Cat. No. Product name CAS No.
DC65769 1-Stearoyl-2-myristoyl-sn-glycero-3-PC Featured

1-Stearoyl-2-myristoyl-sn-glycero-3-PC (1S-2M-PC) belongs to the class of asymmetric phospholipids. 1-Stearoyl-2-myristoyl-sn-glycero-3-PC is abundant in biological membranes.

20664-02-2
DC65770 DMPE-mPEG2000(NA盐) Featured

384835-59-0
DC65771 DMG-mPEG5000 Featured

DC65772 rac-1,2-Distearoyl-3-chloropropanediol Featured

rac-1,2-Distearoyl-3-chloropropanediol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

72468-92-9
DC65773 1,2-Distearoyl-sn-glycerol Featured

1,2-Distearoyl-sn-glycerol (DSG; 1,2-Dioctadecanoyl-sn-glycerol) acts as an internal standard for Separation and identification of molecular species of 1,2-diacyl-sn-glycerol (DAG).

10567-21-2
DC65774 1,2-Dipalmitoyl-rac-glycerol Featured

1,2-Dipalmitoyl-rac-glycerol is a diacylglycerol containing palmitic acid at the sn-1 and sn-2 positions. It is found in a variety of vegetable oils, including palm, soybean, canola, and corn. 1 \n 1,2-Dipalmitoyl-rac-glycerol MaxSpec Standard is a quantitative grade standard of 1,2-dipalmitoyl-rac-glycerol prepared for mass spectrometry and related applications requiring quantitative reproducibility . The solution has been prepared gravimetrically and contained in argon-sealed deactivated glass ampoules. Concentrations were verified by comparison to independently prepared calibration standards. This 1,2-dipalmitoyl-rac-glycerol MaxSpec Standard is guaranteed to meet specifications for identity, purity, stability, and concentration and is supplied with a batch-specific Certificate of Analysis. Ongoing stability testing is performed to ensure concentrations remain accurate throughout the shelf life of the product. Note: Add more solution to the vial than listed. Therefore, accurate volume measurements are necessary to prepare calibration standards. Follow recommended storage and handling conditions to maintain product quality.

40290-32-2
DC65775 1,3-Dipalmitoyl-2-oleoyl Glycerol Featured

2190-25-2
DC65776 1,2-Dipalmitoyl-sn-phosphoglycerol(ammonium sait) Featured

1373168-73-0
DC65777 DLPA Featured

DLPA is a phosphatidic acid (PA) containing the medium-chain (12:0) lauric acid.

108321-06-8
DC65778 PLinPE Featured

26662-95-3
DC65779 PLPA Featured

322647-59-6
DC65780 DLPE Featured

DLPE is a derivative of phosphatidylethanolamine with lauric acid (12:0) acyl chains.

59752-57-7
DC65781 DPyPE Featured

DPyPE is a phosphatidylethanolamine lipid composed of polyisoprene alkyl chains. DPyPE is a co-lipid forvaxfectin mixed with GAP-DMORIE in a 1:1 ratio.

201036-16-0
DC65782 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine Featured

1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine is the main degradation product of deltamethrin metabolized by the prokaryotic protein (CYP6A14 and CYP6N6) complexes in vitro.

89576-29-4
DC65783 JDN18957 Featured

Also known as 1-Stearoyl-2-Oleoyl-sn-glycero-3-PE. It is is a phospholipid that contains stearic acid and oleic acid

6418-95-7
DC65784 SOPA-NA Featured

384833-24-3
DC65785 18:0 Diether PC Featured

1188-85-8
DC65786 mPEG2000-DSPE Featured

mPEG2000-DSPE is used in COVID 19 mRNA vaccines. It is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . Formulations containing DSPE-MPEG(2000) have been used to prepare liposomes with long circulation time for the delivery of anticancer and antimalarial agents.. mPEG2000-DSPE has also been widely used as hydrophilic surface modifying agent for a variety types of hydrophobic nanoparticles, including recently reported lipid nanoparticle mRNA vaccines.

247925-28-6
DC65787 DOP-DEDA Featured

2247753-10-0
DC65788 DHSM Featured

54353-31-0
DC65789 HUN86681 Featured

HUN86681, also known as 1-Hexadecyl-2-acetylphosphatidylcholine, is a lipid Platelet activating factor (PAF). PAF is an ether phospholipid known to exhibit potential biological activities in a variety of cellular phenomena such as platelet aggregation, chemotaxis, hypotension, bronchoconstriction, vascular permeability regulation, inflammation, glycogenesis and in regular cellular breakdown of phosphatidylinositol.

77286-68-1
DC65790 1,2-Dipalmitoyl-sn-glycerol Featured

1,2-Dipalmitoyl-sn-glycerol is an endogenous metabolite.

30334-71-5
DC65791 DPPG sodium Featured

DPPG sodium is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

67232-81-9
DC65792 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine Featured

1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine can be chosen as a model used to investigate the volatile compounds from oxidised phosphatidylcholine molecular species. This method is applied to a real food sample, i.e. soy lecithin.

27098-24-4
DC65794 O-LySoPC Featured

19420-56-5
DC65795 2-Bromoisobutyric acid((s)-1,2-dimyristoyl-SN-giycerol)ester Featured

DC65796 Tritridecanoin Standard Featured

26536-12-9
DC65797 Diheptanoyllecithin Featured

Diheptanoyllecithin is a non-hydrolyzable analog.

39036-04-9
DC65798 DBr-1 Featured

DCAF1-BRD9 PROTAC DBr-1 potently degrades BRD9 with a DC50 of 90 nM but only weakly affected BRD7 protein levels. DBr-1 provides an alternative strategy to tackle intrinsic resistance to VHL-degrader.

DC65799 Compound 38 (NNMT inhibitor) Featured

Compound 38 (NNMT inhibitor) is a potent uncompetitive inhibitors of nicotinamide n-methyltransferase (NNMT). Compound 38 inhibits NNMT in both in vitro biochemical and cell-based assays with IC50 = 42 nM and 38 nM, respectively. Compound 38 shows favorable PK/PD and safety profiles as well as excellent oral bioavailability and pharmaceutical properties.

DC65800 ARV-393 Featured

ARV-393 is an orally active PROTAC that utilizes the ubiquitin-proteasome system to target the degradation of BCL6. ARV-393 consists of ligand conjugates targeting BCL6 and the E3 ligase cereblon, respectively. ARV-393 has DC50 and GI50 values of <1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). ARV-393 also demonstrated considerable tumor suppressor activity in tumor xenograft models. ARV-393 is being studied to inhibit non-Hodgkin lymphoma.

2851885-95-3
DC65801 ARV-102 Featured

a LRRK2 degrader for the treatment of PD and PSP

DC65803 KT-294 Featured

a TYK2 degrader for multiple immune-mediated diseases.

DC65804 HP518 Featured

an AR degrader for the treatment of mCRPC.

DC65805 BMS-986365 (CC-94676) Featured

BMS-986365 (CC-94676) is a highly potent and selective AR degrader that induces rapid and deep degradation of both wildtype and mutant forms of the receptor residing in either the cytoplasmic or nuclear compartments of the cell. BMS-986365 (CC-94676) is about 100-fold more potent than enzalutamide (ENZ) at inhibiting androgen-stimulated transcription of AR target genes, and 10 to 120-fold more potent than ENZ at inhibiting AR-dependent proliferation of multiple prostate cancer cell lines in vitro.

2446928-30-7
DC65806 AC682 Featured

an ER degrader for the treatment of BC.

DC65807 BGB-16673 Featured

a BTK degrader for the treatment of B-cell malignancies.

DC65808 HSK-29116 Featured

a BTK degrader for the treatment of B-cell malignancies.

DC65809 CG001419 Featured

a mutant and wild-type NTRK degrader for the treatment of solid tumors.

DC65810 KT-333 Featured

KT-333 is a molecular glues that degrades STAT3 protein. KT-333 mediates the selective degradation of STAT3 through the ubiquitin-proteasome system by binding to STAT3 protein and E3 ubiquitin ligase von Hippel-Lindau protein (VHL). KT-333 has strong selectivity for STAT3 protein degradation and good antitumor activity. KT-333 can be used in the study of hematologic malignancies such as large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL).

2502186-79-8
DC65811 KT-253 Featured

a MDM2 degrader for the treatment of r/r high grade myeloid malignancies and solid tumors.

DC65812 ASP3082 Featured

a KRASG12D degrader for the treatment of solid tumors.

DC65813 FHD-609 Featured

a BRD9 degrader for treating synovial sarcoma.

2676211-64-4
DC65814 GT-20029 Featured

a topical AR degrader for the treatment of acne vulgaris.

DC65815 20-HETE inhibitor-1 Featured

20-HETE inhibitor-1 (comp 83) is a 20-HETE formation inhibitor

2472030-28-5
DC65816 APG-2575 (lisaftoclax) Featured

APG-2575 (lisaftoclax) is a dual Bcl-2 and Bcl-xl inhibitor with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively.

2180923-05-9
DC65817 Compound 4 (VHL-CDO1 glue degrader) Featured

Compound 4 (VHL-CDO1 glue degrader) is a molecular glue degrader for cysteine dioxygenase 1 (CDO1) by recruiting it into the Von Hippel-Lindau (VHL) E3 ligase complex and leading to its selective degradation.

DC65818 CMX990 Featured

CMX990 is a novel covalent SARS-CoV-2 3CL protease inhibitor with EC50 of 10 nM, and shows good oral bioavailability and tolerability in preclinical species. Compared with nirmatrelvir, CMX990 has distinctly differentiated potency (~5-fold more potent in primary cells) and human in vitro clearance (>4-fold better microsomal clearance and >10-fold better hepatocyte clearance), with good in vitro-to-in vivo correlation.

2882934-64-5
DC65819 Acetylcholine Featured

Acetylcholine is stored in vesicles in the presynaptic neuron. These fuse with presynaptic membrane upon stimulation by a nerve signal, thus, generating a pulse of neurotransmitter, which diffuses across the membrane. Acetylcholine may either bind reversibly to one of two different types of acetylcholine receptors on the postsynaptic membrane or be destroyed by the acetylcholine-hydrolyzing enzyme, acetylcholinesterase.

51-84-3
DC65820 Synucleozid-2.0 Featured

Synucleozid-2.0 is a drug-like small molecule that decreases α-Synuclein (SNCA) levels by inhibiting ribosomes from assembling onto SNCA mRNA. Synucleozid-2.0 dose-dependently inhibits SNCA translation with IC50 of ~2 µM.

DC65821 Upadacitinib hemihydrate Featured

Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor with an IC50 of 43 nM, being developed for the treatment of several autoimmune disorders.

2050057-56-0
DC65822 Valemetostat tosylate Featured

Valemetostat (DS-3201) tosylate, a first-in-class EZH1/2 dual inhibitor with IC50 values <10 nM. Valemetostat tosylate can be used for the research of relapsed/refractory peripheral T-cell lymphoma.

1809336-93-3
DC65823 IR-820(New Indocyanine Green) Featured

IR-820 is a near infrared dye with its excellent fluorescence penetration, good color rendering and better stability. IR-820 is an infrared blood pool contrast agent to detect and quantify diseased tissue in live animals. IR-820 has maximal excitation and emission wavelengths of 710 and 820 nm, respectively. IR-820 emission is significantly improved in vivo on serum binding to albumin, and elimination occurs predominantly via the gastrointestinal tract. Note: this product has ~80% dye.

172616-80-7
DC65824 PKH 26 Featured

PKH 26 is a red fluorescent dye, PKH 26 can stably bind to the lipid region of cell membrane and emit red fluorescence (Ex/Em=551/567 nm), which is mainly used for in vitro cell labeling, in vitro cell proliferation studies and in vivo and in vitro cell tracing studies.

154214-55-8
DC65825 5(6)-Carboxyfluorescein Featured

5(6)-Carboxyfluorescein (5(6)-FAM) is an amine-reactive pH-sensitive green fluorescent probe. 5(6)-Carboxyfluorescein (5(6)-FAM) can be used to label proteins, peptides and nucleotides. 5(6)-Carboxyfluorescein can be used for the detection of tumour areas in vivo.

72088-94-9
DC65826 SYBR(R) GREEN I NUCLEIC ACID GEL STAIN Featured

163795-75-3
DC65827 DiR Featured

DiR is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins.

100068-60-8
DC65828 Methylliberine Featured

51168-26-4
DC65829 Tetramethyluric acid Featured

Tetramethyluric acid (1,3,7,9-Tetramethyluric acid; Theacrine), also known as tetramethyluric acid or theophylline, is a purine alkaloid with a structure similar to caffeine. Tetramethyluric acid is a biomaterial or organic compound that can be used as a research-related biomaterial or organic compound in life sciences.

2309-49-1
DC65830 1-M-PES(1-Methoxy-5-methylphenazinium ethyl sulfate) Featured

1-m-PES is an electron mediator which has higher stability of solutions than 1-Methoxy PMS. The stability in neutral to alkali conditions has been extremely improved with 1-Methoxy PES. 1-M-PES is a stable small-molecular compound and it has an equal or higher thermal stability than diaphorase. The 1-Methoxy PES solution can be stored long term.

DC60545 200Oi10 Featured

200Oi10 is an ionizable lipidoid. 200Oi10 formulated LNPs facilitate mRNA delivery to the pancreas.

DC60546 514O6,10 Featured

514O6,10 is an ionizable lipidoid. 514O6,10 formulated LNPs facilitate mRNA delivery to the pancreas.

DC60548 IBG1 Featured

IBG1 is a PROTAC-like degrader, which comprises JQ1 tethered to E7820. IBG1 selectively degraded BRD2 and BRD4 but not BRD3. IBG1 results in potent BRD4 degradation with DC50 of 0.15 nM and pronounces growth inhibition in various cancer cell lines.

DC60549 IBG3 Featured

IBG3 is a PROTAC-like degrader. IBG3 shows greater degradation efficiencies over BRD4 and BRD2 than those of IBG1 with DC50 of 6.7 pM and 8.6 pM, respectively.

DC60550 IBG4 Featured

IBG4 is a PROTAC-like degrader. IBG4 shows high specificity for BRD4 and does not efficiently degrade BRD2.

DC65831 LNK01001 Featured

DC65832 GT20029 Featured

DC65833 LNK01002 Featured

DC65834 LNK01003 Featured

DC65835 PF-04745637 Featured

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1.

1917294-46-2
DC65836 H5K29116 Featured

DC65837 MZ-001 Featured

DC65838 CFT8919 Featured

DC65839 MC1 Precursor Featured

Precursor of MC1, which is a selective and potent inhibitor for COX-2, used as the radioligands for development as clinically useful PET radioligands.

1018480-97-1
DC65840 KYM-001 Featured

DC65841 MC1 Featured

MC1 is a selective and potent inhibitor for COX-2, and [11C]MC1 detected COX-2 in nonhuman primates after intracerebral injection of an inflammogen.

1018480-89-1
DC65842 0G416 Featured

DC65843 HC-X029 Featured

DC65844 ICP-490 Featured

DC65845 GT-919 Featured

DC65846 MGD molecule Featured

DC60547 ZNL-0056 Featured

ZNL-0056 is an ATP-competitive inhibitor that targets both the Cys797 and Cys775 in the ATP binding site of EGFR, which is the first compound capable of targeting a nonconserved and partially buried Cys775.

2767987-38-0
DC60551 Compound 181 Featured

Compound 181 is a selective and highly potent stabilizer of the 14-3-3σ/ERα complex. Compound 181 shows potency comparable to the natural product Fusicoccin-A.

DC60553 Mosnodenvir ( JNJ-1802) Featured

Mosnodenvir (JNJ-1802) is an orally active pan serotype dengue virus (DENV) inhibitor, with EC50 values ranging from 0.057 to 11 nM for four dengue virus (DENV) serotypes. Mosnodenvir blocks viral replication by inhibiting the formation of complexes between two viral proteins, nonstructural protein 3 (NS3) and NS4B, thereby preventing the formation of new viral RNA. Mosnodenvir exhibits picomolar to nanomolar antiviral activity in vitro and has antiviral efficacy in mice and non-human primates.

2890688-86-3
DC60554 Lipid 20b Featured

Lipid 20b is an ionizable lipid containing a thiophene moiety (Thio-lipid) for mRNA delivery. Lipid 20b enables LNPs to transfect the liver and spleen. Lipid 20b is potent in mRNA delivery to the retina with no acute toxicity.

DC60555 C14-O2 Featured

C14-O2 is an oxidized lipid for mRNA delivery. C14-O2-LNP is capable of potent and selective delivery of mRNA to blood monocytes. C14-O2 LNP is used to deliver a functional CD19-CAR mRNA and is shown to engineer functional CAR monocytes directly in situ.

2639634-77-6
DC60556 Lipid 29d Featured

Lipid 29d is an ionizable lipid containing a thiophene moiety (Thio-lipid) for mRNA delivery. Lipid 29d enables LNPs to transfect the lung and spleen.

DC65848 1,2-didecanoyl-sn-glycero-3-phosphate (sodium salt) Featured

1,2-didecanoyl-sn-glycero-3-phosphate is one kind of phosphatidic acid, which is a minor constituent of biological membranes is a simplest glycerophospholipid. It has glycerol backbone with phosphate present at C-3 position. The C-1 and C-2 positions are esterified with fatty acids.It is used as a component in the lipid bilayer to study how lipid geometry acts in coat protein I (COPI) vesicle fission, and maybe used to activate protein kinase C (PKC).

321883-64-1
DC65849 A1-28 Featured

A1-28 is a disulfide bond-containing ionizable cationic lipid.1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for genome editing in vitro.

DC65850 VL422 Featured

VL422 is an ionizable cationic lipid.1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for gene editing in vitro and in vivo. LNPs containing VL422 and encapsulating Cas9 mRNA and sgRNA targeting the gene encoding angiopoietin-related protein 3 (ANGPTL3), a protein whose loss-of-function decreases LDL, HDL, and cholesterol plasma levels, induce a deletion in a premature stop codon in ANGPTL3 in the livers of cynomolgus monkeys.

2765519-47-7
DC65851 CL15F6 Featured

CL15F6 is an ionizable cationic lipid (pKa = 6.75).1 It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA and polymer-lipid hybrid nanoparticles for the delivery of plasmid DNA in vitro.1,2

2766493-40-5
DC65852 C3-K2-E14 Featured

C3-K2-E14 is an ionizable cationic lipid (pKa = 5.5).1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA or siRNA in vitro and in vivo. LNPs containing C3-K2-E14 and encapsulating siRNA targeting the gene encoding colony-stimulating factor 1 (Csf1) reduce the percentage of circulating Ly6Chi monocytes and increase the percentage of circulating Ly6Cint monocytes in mice.

2933215-86-0
DC65853 (S)-C12-200 Featured

(S)-C12-200 is an ionizable cationic lipid (pKa = 7.12) and an isomer of C12-200 (Item No. 36699).1 It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Intravenous administration of LNPs containing (S)-C12-200 and encapsulating mRNA encoding Cre recombinase increase the percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the livers of Ai14 mice greater than (R)-C12-200-containing and Cre mRNA-encapsulating LNPs.

1226552-44-8
DC65854 PPPDA-O16B Featured

PPPDA-O16B is a disulfide bond-containing ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for plasmid delivery in vitro and in vivo.1 LNPs containing PPPDA-O16B and encapsulating plasmids encoding Ras/Rap1-specific endopeptidase (RRSP) increase RRSP levels and decrease Ras levels in, and reduce the viability of, HeLa cervical cancer cells. LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP selectively localize to tumors over the heart, liver, spleen, lungs, and kidneys, as well as decrease tumor volume without reducing body weight, in an HCT116 colorectal cancer mouse xenograft model.

DC65856 Lipid C3 Featured

Lipid C3 is an ionizable cationic lipid (pKa = 5.05-5.671).1,2 It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 Intracerebroventricular administration of LNPs containing lipid C3 and encapsulating mRNA encoding α-L-iduronidase (Idua) to neonates increase midbrain and hippocampal α-L-iduronidase enzyme activity and decrease forebrain, midbrain, and hippocampal glycosaminoglycan levels in an Idua-W392X mouse model of the lysosomal storage disorder mucopolysaccharidosis type I, also known as Hurler syndrome. Intracerebroventricular administration of LNPs containing lipid C3 and encapsulating an mRNA reporter to fetal macaques in utero increase brain GFP expression.

2639634-93-6
DC65857 BAmP-O16B Featured

BAmP-O16B is an ionizable cationic amino lipid that has been used in the generation of lipid nanoparticles (LNPs).1 LNPs containing BAmP-O16B and encapsulating NSA-inactivated RNase A reduce the viability of SiHa and HeLa cancer cells, but not non-cancerous NIH3T3 and HEK293T cells, upon intracellular reactivation of RNase A by glutathione (GSH).

DC65858 Lipid OA2 (hydrochloride) Featured

Lipid OA2 is an ionizable cationic lipid that has been used in the generation of single-component lipid nanoparticles (LNPs) for the delivery of siRNA.1 LNPs containing lipid OA2 and siRNA targeting the gene encoding suppressor of cytokine signaling 1 (Socs1) decrease Socs1 expression by approximately 50% in isolated mouse bone marrow dendritic cells (BMDCs). Vaccination with ovalbumin-induced isolated mouse BMDCs transfected with LNPs composed of lipid OA2 and Socs1-targeting siRNA increases survival and decreases tumor volume in a B16-OVA murine melanoma model.

DC60557 Compound 11 (EBP inhibitor) Featured

Compound 11 (EBP inhibitor) is a selective orally bioavailable, brain-penetrant emopamil binding protein (EBP) inhibitor with EC50 of 44 nM. Compound 11 enhances the formation of oligodendrocytes in human cortical organoids.

DC60558 Lung endothelium-targeted Lipid-1 Featured

Lung endothelium-targeted Lipid-1 is used in pulmonary endothelium targeted mRNA delivery. Lung endothelium-targeted Lipid-1 formulated nanoparticle, Lung-LNP (LuLNP) is capable of delivering therapeutic mRNA cargo for vascular repair in influenza infection.

DC65859 CRT0066101 Featured

CRT0066101 is a PRKDs inhibitor. CRT0066101 suppressed the proliferation and migration of four bladder cancer cell lines in vitro. CRT0066101 blocked tumor growth in a mouse flank xenograft model of bladder cancer. CRT0066101 treatment or PKD2 silencing arrested bladder cancer cells at the G2/M phase, the arrest being accompanied by decreases in the levels of cyclin B1, CDK1 and phospho-CDK1 (Thr161) and increases in the levels of p27Kip1 and phospho-CDK1 (Thr14/Tyr15). CRT0066101 suppresses bladder cancer growth by inhibiting PKD2 through induction of G2/M cell cycle arrest, leading to the blockade of cell cycle progression.

956121-30-5
DC65860 HA155 Featured

HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC50 of 5.7 nM.

1312201-00-5
DC65861 PF-CBP1 Featured

PF-CBP1, also known as PF-06670910, is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates targets of CBP in macrophages primary neurons.

962928-21-7
DC65862 GSK-3 Inhibitor XIII Featured

GSK-3 Inhibitor XIII is a potent and ATP-competitive GSK-3 inhibitor with a Ki of 24 nM.

404828-14-4
DC65863 Ac-trineapac Featured

DC65864 1-(5-bromo-2-chlorobenzyl)-4-(4-methoxybenzyl)piperazine Featured

DC65865 tert-butyl 2-(4-(5-(methylcarbamoyl)-1H-benzo[d]imidazol-1-yl)phenyl)acetate Featured

DC65866 Methyl 4-((2-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol- 5-yl)carbamoyl)benzoate Featured

DC65867 (S)-N-(5-(6-fluoropyridin-3-yl)-2,3-dihydro-1H-inden-2-yl)propane-2-sulfonamide Featured

DC65868 NIH-1 Featured

DC65869 N1,N2-bis(1,2,3,4-tetrahydroacridin-9-yl)ethane-1,2-diamine Featured

DC65870 NVOC cage-TMP-Halo Featured

NVOC cage-TMP-Halo is a cell-permeable and photoactivatable protein dimerization inducer. NVOC cage-TMP-Halo can rapidly and reversibly control protein localization in living cells. NVOC cage-TMP-Halo can be used for dynamic cellular processes research.

2137894-98-3
DC65871 Phylloflavan Featured

Phylloflavan is an antileishmanial agent with an intracellular EC50 of 3.2 nM in RAW 264.7 cells. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblast cells (38 U/mL).

98570-83-3
DC65872 Comp-43 Featured

DC65873 Benzamide Featured

Benzamide is a small molecule Magmas inhibitor (SMMI). Magmas is mitochondria associated,granulocyte-macrophage colony stimulating factor signaling molecule,as well as a GM-CSF inducible gene in myeloid cells. Magmas-IN-1 inhibits Magmas and modulates mitochondrial function. Magmas-IN-1 also inhibits proliferation in yeast at 4 μM.

1251957-89-7
DC65874 AKOS037652256 Featured

2171065-77-1
DC65875 Benzyl Benzodithioate Featured

60795-38-2
DC65876 VT-105 Featured

VT-105 is a potent and selective TEAD Auto-palmitoylation inhibitor that Inhibits Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT105 is a more soluble analog of VT104.

2417718-38-6
DC65877 ST33777 Featured

1343704-88-0
DC65878 ST-33447 Featured

DC65879 AP1189 acetate Featured

AP1189 is a biased agonist at receptors MC1 and MC3. AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes. In vivo, oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ∼3-fold.

959850-74-9
DC65880 HaloPROTAC-E Featured

HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1, and ATG14) and no other proteins were significantly degraded.

2365478-58-4
DC65881 Afabicin Featured

Afabicin (formerly Debio 1450, AFN-1720) is a prodrug of afabicin desphosphono, an enoyl-acyl carrier protein reductase (FabI) inhibitor, and is a first-in-class antibiotic with a novel mode of action to specifically target fatty acid synthesis in Staphylococcus spp.

1518800-35-5
DC65882 Methyl 2-Formyl-1H-Pyrrole-3-Carboxylate Featured

19075-68-4
DC65883 3,5-Dichloro-6-iodopyrazolo[1,5-a]pyrimidine Featured

2640353-16-6
DC65884 CCR2-RA Featured

512177-31-0
DC65885 Stilbamidine dihydrochloride Featured

Stilbamidine dihydrochloride is a blocker of neuromuscular transmission and axonal conduction. It is used to study the distribution of the drug in the organs and tissues of rats following intravenous injection.

6935-63-3
DC65886 MCU-i11 Featured

MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.

902903-59-7
DC65888 2,4,6-Triisopropyl-m-phenylene diisocyanate Featured

2162-73-4
DC65889 3-Oxa-1-azaspiro[4.5]decane-2,4-dione Featured

3253-43-8
DC65890 5,5-Difluoro-5a-methyl-1H,4H,4aH,5H,5aH,6H-cyclopropa[f]indazole-3-carboxylic acid Featured

1557248-38-0
DC65891 GI 181771 Featured

GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity.

305366-98-7
DC65892 Cyclopropyl-prop-2-ynyl-amine Featured

49565-47-1
DC65893 Pyrithione Featured

Pyrithione, a Transition metal complexe, is a zinc ionophore that causes increased zinc levels within mammalian cells. Pyrithione has potent bactericidal and anti-fungal activity.

1121-30-8
DC65894 3-bromo-2-(2-hydroxyethyl)thiophene Featured

141811-49-6
DC65895 5-Acetyl-2-bromobenzaldehyde Featured

2383820-38-8
DC65896 PSB-15160 Featured

215997-93-6
DC65897 SLU-PP-1072 Featured

SLU-PP-1072 is a novel Selective ERRα/γ Inverse Agonist, Inhibiting the Warburg Effect and Inducing Apoptosis in Prostate Cancer Cells.

2285432-57-5
DC65898 LMTK3 inibitor C28 Featured

LMTK3-IN-1 (compound C28) is an ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM),that acts by degrading LMTK3 via the ubiquitin-proteasome pathway. LMTK3-IN-1 shows anticancer activity in a variety of cancer cell lines and in vivo BC mouse models. LMTK3-IN-1 induces apoptosis in BC cell lines at 10-20 μM.

2764850-23-7
DC60559 PT-179 Featured

PT-179 is a new orthogonal immunomodulatory drug (IMiD) derivative that binds CRBN but does not induce degradation of off-target proteins. PT-179 potently degrades proteins fused to SD40 at either the N or C terminus.

2924858-25-1
DC65899 Des-iPr-TAS-116 Featured

DC65900 1-Piperidinecarboxylic acid, 4-bromo-3-oxo-, 1,1-dimethylethyl ester Featured

784139-99-7
DC65901 PSB-1901 Featured

PSB-1901 is a potent A2B adenosine receptor (A2BAR) antagonist with Kis of 0.0835 nM and 0.131 nM for human and mouse A2BARs respectively. PSB-1901 can be used for the research of cancer.

2332835-02-4
DC65902 2-Amino-8-oxononanoic acid HCl Featured

2-Amino-8-oxononanoic acid HCl is a biochemical

DC65903 (2Z)-2-Fluorobut-2-enedioic acid Featured

2-Fluorofumarate is a bioactive chemical.

672-18-4
DC65904 1-Cyanocyclopropy Featured

1461707-09-4
DC65905 CB75559092 Featured

2135331-92-7
DC65906 4-bromo-1-(phenylmethyl)- 3-Piperidinone Featured

775225-43-9
DC65907 Protonstatin-1 Featured

Protonstatin-1 is a selective small-molecule inhibitor of PM H+ -ATPase activity that inhibits auxin transport.

521972-99-6
DC65908 SBFI-26 Featured

SBFI-26 (SBFI26) is a small molecule inhibitor of epidermal- and brain-specific FABP5 and FABP7 that effectively increases anandamide signaling; dose-dependently reduces mechanical hyperalgesia in vivo, demonstrates significant analgesic and anti-inflammatory properties; also suppresses the malignant progression of castration resistant prostate cancer cells by competitively binding to oncogenic FABP5.

1541209-75-9
DC65909 IM176OUT05 Featured

IM176OUT05 is a high solubility biguanide. IM176OUT05 activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process. IM176OUT0 inhibits mitochondrial electron transport chain (ETC) activity with an IC50 of 3.2 μM.

1643659-96-4
DC65910 3-Amino-4,5-dimethylthiophene-2-carboxylic acid Featured

98547-43-4
DC65911 WAY-639483 Featured

791125-94-5
DC65912 5-HT2A receptor agonist-3 Featured

5-HT2A receptor agonist-3 is the most selective agonist for the human 5-HT2A receptor yet discovered, with a Ki of 2.5 nM, and with 124-fold selectivity for 5-HT2A over the structurally similar 5-HT2C receptor.

1391499-52-7
DC65913 ß-pBrPh-Glc Featured

β-pBrPh-Glc is a small-molecule ice recrystallization inhibitor. β-pBrPh-Glc can control the rate and extent of intracellular ice recrystallization in the nuclei over a broad range of subzero temperatures. β-pBrPh-Glc is an important tool to improve the recovery and function of cryopreserved cells and tissues.

30572-42-0
DC65914 WAY-326363 Featured

anti-dengue virus infections;

870757-57-6
DC65915 Cyclopentanesulfonamide (9CI) Featured

73945-39-8
DC65916 MMP-9-IN-7 Featured

MMP-9-IN-7 is a potent MMP9 inhibitor with an IC50 of 0.52 μM in proMMP9/MMP3 P126 activation assay. MMP-9-IN-7 is extracted from patent WO2012162468 (example 59), and can be used for MMP9/MMP13 mediated syndrome research.

333746-76-2
DC65917 B-Raf IN 14 Featured

B-Raf IN 14 (Comp 25) is a BRAF inhibitor with IC50 value of 11.08 μM, which can be used in cancer-related research.

326918-98-3
DC65918 PI3Kα-IN-11 Featured

PI3Kα-IN-11 is a potent PI3Kα inhibitor with anticancer activity.

300803-79-6
DC65919 WAY-326312 Featured

useful for preventing or treating obesity, dyslipidemia, fatty liver or diabetes;

869875-89-8
DC65920 5-bromo-3-fluorothiophene-2-carboxylic acid Featured

1432060-81-5
DC65921 WAY-310507 Featured

Mycobacterium tuberculosis shikimate kinase inhibitors

686743-93-1
DC65922 4-((Prop-1-en-1-yloxy)methyl)-1,3-dioxolan-2-one Featured

130221-78-2
DC65923 WAY-658876 Featured

inhibitor of the human soluble epoxide hydrolase

863558-02-5
DC65924 WAY-325104 Featured

neuroprotective effects; altering the lifespan of a eukaryotic organism;

500272-00-4
DC65925 T417 (PBX1 inhibitor T417, TCRS-417) Featured

TCRS-417 (T417) is a small molecule compound capable of docking to the interface between PBX1 and its cognate DNA target sequence, effectively interfering with PBX1-DNA interaction. TCRS-417 can be used in the research of cancer, developmental disorders, inflammatory disorders, autoimmune diseases or neurodegenerative diseases.

2032123-28-5
DC65926 WAY-327366 Featured

calcium channel antagonist

687568-55-4
DC65927 WAY-325855 Featured

inhibitor of Ral GTPases

868357-74-8
DC65928 WAY-662162 Featured

Inhibitor of UDP-galactopyranose mutase;

902471-48-1
DC65929 Ethyl 2-amino-5-cyano-4-methylthiophene-3-carboxylate Featured

43028-74-6
DC65930 CRT0063465 Featured

CRT0063465 is a novel Ligand of Human PGK1 and Stress Sensor DJ1, Modulating the Shelterin Complex and Telomere Length Regulation.

DC65931 WAY-324101 Featured

Protein tyrosine Phosphatase 1B (PTP1B) agonist

373377-66-3
DC65932 WAY-326860 Featured

inhibitor of flavivirus replication

685844-21-7
DC65933 WAY-622216 Featured

altering the lifespan of a eukaryotic organism; anti-viral;

556050-16-9
DC65934 2-(Thiobenzoylthio)propionic acid Featured

78751-36-7
DC65935 Enterobactin Featured

Enterobactin is a high affinity siderophore that acquires iron for microbial systems.

28384-96-5
DC65936 (S)-BnCH2-PyBox, (S,S)-2,6-Bis(4-benzylmethyl-2-oxazolin-2-yl)pyridine Featured

1012042-02-2
DC65937 clenpirin Featured

Clenpirin is a bio-active chemical.

27050-41-5
DC65938 Naphthol AS-TR Phosphate Disodium Salt Featured

Naphthol AS-TR Phosphate disodium is a water-soluble dye commonly used as an enzymatic substrate in various biochemical assays to detect alkaline phosphatase activity. Naphthol AS-TR Phosphate disodium has unique chemical properties that allow it to be hydrolyzed by alkaline phosphatase, forming a colored product that can be detected spectrophotometrically. This makes it a useful tool for monitoring enzyme activity in biological samples such as serum or urine.

4264-93-1
DC65939 [bromo(difluoro)methyl]benzene Featured

83170-17-6
DC65940 3-((1-carboxyvinyl)oxy)benzoic acid Featured

16929-37-6
DC65941 AF615 Featured

122510-61-6
DC65942 4-Ethynyl-N-ethyl-1,8-napthalamide Featured

912921-26-7
DC65943 Naphthol AS-BI phosphate disodium salt Featured

530-79-0
DC65944 N406211 Featured

1820570-99-7
DC65945 Imiloxan hydrochloride Featured

Imiloxan hydrochloride is a potent and selective alpha 2B-adrenoceptor antagonist. Imiloxan hydrochloride has the potential for acute kidney injury research.

81167-22-8
DC65946 (R)-(-)-α-Methylhistamine dihydrobromide Featured

(R)-(-)-α-Methylhistamine dihydrobromide is a potent, selective and brain-penetrant agonist of H3 histamine receptor, with a Kd of 50.3 nM. (R)-(-)-α-Methylhistamine dihydrobromide can enhance memory retention, attenuates memory impairment in rats.

868698-49-1
DC65947 (S)-(+)-2-Chlorophenylglycine Methyl Ester Tartrate Salt Featured

141109-15-1
DC65948 2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine, Hydrochloride Featured

127337-60-4
DC65949 2-Mercaptobenzimidazole Featured

583-39-1
DC65950 (S)-(+)-2-Chlorophenylglycine Methyl Ester Featured

141109-14-0
DC65951 PTP1B-IN-4 Featured

PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes.

765317-72-4
DC65952 10-Hydroxygeraniol Featured

26488-97-1
DC65953 10-Formyl Folic Acid Featured

10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase.

134-05-4
DC65954 OTUB1/USP8 inhibitor 61 Featured

OTUB1/USP8-IN-1 is a potent dual OTUB1/USP8 inhibitor with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively. OTUB1/USP8-IN-1 can be used in research of cancer.

2858800-98-1
DC65955 GOSLO SR 5-69 Featured

GoSlo-SR-5-69 is a potent activator of large conductance Ca2+-activated K+ (BK) channels, with an EC50 of 251 nM.

1363419-31-1
DC65956 Dicyclopenta[b,e]pyridin-8(1H)-imine, 2,3,4,5,6,7-hexahydro-4-methyl- Featured

445463-11-6
DC65957 8-Azabicyclo[3.2.1]octane-8-carboxamide, 3-(2-pyridinylsulfonyl)-N-[4-(trifluoromethyl)phenyl]- Featured

1135000-36-0
DC65958 3-Hydroxy-4,5-bis-benzyloxy-6-benzyloxymethyl-2-phenyl2-oxo-2λ5-[1,2]oxaphosphinane Featured

DC65959 Vocacapsaicin hydrochloride Featured

Use of Vocacapsaicin hydrochloride Vocacapsaicin (CA-008) hydrochloride, a prodrug of Capsaicin, is a first-in-class non-opioid TRPV1 agonist. Vocacapsaicin hydrochloride can provide meaningful and long-lasting pain relief.

1931116-92-5
<Prev1...4243444546...54Next>