| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11280 | GSK1016790A Featured | GSK1016790A is a novel and potent TRPV4 channel agonist. |
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| DC10865 | GSK2193874 Featured | GSK2193874 is an orally active, potent, and selective TRPV4 antagonist with IC50 of 2 nM and 40 nM for rTRPV4 and hTRPV4. |
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| DC9712 | Iinerixibat | GSK2330672 is a highly potent, nonabsorbable ASBT(apical sodium-dependent bile acid transporter) inhibitor (hASBT IC50=42 ± 3 nM) . |
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| DC8303 | GTS 21 2HCl(DMXBA) Featured | GTS 21 dihydrochloride is a partial agonist of α7 nicotinic acetylcholine receptors (nAChRs); also a weak α4β2 and 5-HT3 antagonist at micromolar concentrations. |
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| DC5061 | GYKI 52466 dihydrochloride | GYKI 52466 dihydrochloride is a selective non-competitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and >> 50 μM for AMPA- , kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. |
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| DC11416 | HC-067047 Featured | HC-067047 is a potent and selective TRPV4 antagonist with IC50 values of 48 ± 6 nM, 133 ± 25 nM, and 17 ± 3 nM, respectively in human, rat, and mouse. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). |
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| DC11118 | HZ-166 | HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand with preferential activity at α2- and α3-GABA(A) receptors. |
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| DC8601 | IAA-94 | IAA-94 is an indanyloxyacetic acid blocker of epithelial chloride channels. |
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| DC10078 | ICA 069673 Featured | ICA 069673 is a potassium channel opener with selective action for KCNQ2 and KCNQ3 (EC50=0.69 μM). No meeasurable activity was displayed over a variety of cardiac ion channels. |
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| DC8213 | ICA-121431 Featured | ICA-121431 is a potent, selective inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels (IC50 = 19 nM) with little or no activity against human Nav1.5 or Nav1.7 channels. |
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| DC7213 | ICILIN Featured | Icilin is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel. |
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| DC8769 | IEM 1754 DihydrobroMide | IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM. |
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| DC11031 | IK1 inhibitor PA-6 | IK1 inhibitor PA-6 is an efficient, specific inhibitor of inward rectifier current (IK1), blocks KIR2.x currents of human and mouse with IC50 of 12-15 nM. |
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| DC10205 | Ilaprazole Featured | Ilaprazole (IY-81149) is a proton pump inhibitor; inhibits H+/K+-ATPase with an IC50 of 6.0 μM. |
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| DC4137 | Indiplon Featured | Indiplon is a novel sedative-hypnotic recently approved for the treatment of insomnia. |
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| DCAPI1506 | Mitiglinide Calcium | Inhibitor of ATP-sensitive K+ channel activity in MIN 6 cells. Has also been shown to bind sulfonylurea receptors as well. |
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| DC8124 | ETH 2120(Sodium ionophore III) Featured | Ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc. with a solvent polymeric membrane electrode. |
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| DC7172 | IOWH-032 | iOWH032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays. |
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| DCAPI1573 | Ipragliflozin (ASP1941) Featured | Ipragliflozin (ASP1941) is a Novel Selective Sodium-Dependent Glucose Co-Transporter 2 Inhibitor, on Urinary Glucose Excretion in Healthy Subjects |
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| DC4128 | Ivacaftor (VX-770) Featured | Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
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| DC12271 | JNJ-54175446 Featured | JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively. |
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| DC11229 | JNJ-55511118 | JNJ-55511118 (JNJ55511118) is a selective, orally available AMPA receptor containing TARP-γ8 negative modulator with Ki of 26 nM, displays no significant activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2. |
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| DC9276 | KM 11060 Featured | KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity. |
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| DC8788 | Ko 143 Featured | Ko 143 is a potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC90 = 26 nM), Ko 143 displays > 200-fold selectivity over P-gp and MRP-1 transporters. |
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| DC7067 | KPT-330(Selinexor) Featured | KPT-330, analog of KPT-185, is an orally bioavailable selective CRM1 inhibitor. |
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| DC9256 | KS176 Featured | KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1. |
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| DC8159 | L-701,324 Featured | L-701,324 is a selective antagonist at the glycine site of the NMDA receptor, counteracts haloperidol-induced muscle rigidity in rats. |
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| DC8797 | Lacosamide Featured | Lacosamide (Vimpat; Erlosamide) is a medication developed for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. |
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| DC10853 | LAU159 Featured | LAU159 is a novelα6β3γ2 GABAA receptor inhibitor. |
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| DC9432 | LDN-212320 Featured | LDN-212320(OSU-0212320) is a glutamate transporter EAAT2 activator; enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h. |
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