Cat. No. | Product name | CAS No. |
DC11323 |
LY354740
LY354740 is an agonist of the group II metabotropic glutamate receptor (mGluR) subtypes mGluR2 and mGluR3 (Kis = 99 and 94 nM, respectively). |
176199-48-7 |
DC7192 |
LY-404039
Featured
LY404039 is an inhibitor for mGluR1(Ki=149 nM) and mGluR2(Ki= 92 nM), which can also inhibit dopamine receptor. |
635318-11-5 |
DC5036 |
LY-411575
Featured
LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with withIC50 of 0.39 nM. |
209984-57-6 |
DC7459 |
LY500307
LY500307 is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2. |
533884-09-2 |
DC8378 |
Mavatrep(JNJ-39439335)
Featured
Mavatrep is an orally bioavailable TRPV1 antagonist (Ki=6.5 nM), exhibits minimal effect on the enzymatic activity (IC50 > 25 μM) of CYP isoforms 3A4, 1A2, and 2D6. |
956274-94-5 |
DC10013 |
Mirogabalin
Featured
Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium-channel complexes in the CNS. |
1138245-13-2 |
DC10532 |
Mirogabalin besylate
Featured
Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium-channel complexes in the CNS. |
1138245-21-2 |
DC9398 |
MK-0974
MK-0974(Telcagepant) is a highly potent, selective, and orally bioavailable CGRP receptor antagonist with Ki values of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors respectively; displays >1500-fold lower affinity for the canine and rat receptors |
781649-09-0 |
DC9966 |
MK-1064
Featured
MK-1064 is a selective orexin 2 receptor antagonist (2-SORA) for the research of insomnia. |
1207253-08-4 |
DC7646 |
MK3697
MK-3697 is a third insomnia drug, currently being developed by Merck. MK-3697 is a potent and selective Orexin receptor antagonist with Ki = 0.95 nM. |
1224846-01-8 |
DC9901 |
Verubecestat (MK-8931)
Featured
MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase. |
1286770-55-5 |
DC9993 |
MK-8998
Featured
MK-8998 is a novel bioactive compound for the treament of psychiatric disease. |
953778-58-0 |
DC10455 |
NE-100
Featured
NE100 hydrochloride is a potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, |
149409-57-4 |
DC11247 |
Nelonicline
Featured
Nelonicline (ABT-126) is a potent, selective α7 nicotinic receptor (nAChR) partial agonist for the treatment of cognitive impairment with schizophrenia.. |
1026134-63-3 |
DC11469 |
APD125(Nelotanserin)
Featured
Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively. |
839713-36-9 |
DC8583 |
Asenapine Maleate
Featured
Novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pKi values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8 |
85650-56-2 |
DC4237 |
NXY-059 (Cerovive)
NXY-059 (Cerovive) is an EGFR and HER2 autophosphorylation inhibitor, against purified EGFR and HER2 of 10.2 and 9.8 nM, respectively. |
168021-79-2 |
DC11905 |
Opiranserin
Opiranserin (VVZ-149, VVZ-000149) is a potent, selective, mixed glycine GlyT2 transporter blocker (IC50= 0.86 uM), purine P2X3 receptor antagonist (IC50=0.87 uM) and serotonin 5-HT2A receptor antagonist (IC50=1.3 uM). |
1441000-45-8 |
DC10394 |
Org-26576
Org 26576 is a AMPA receptor positive allosteric modulator. |
100044-96-0 |
DC11113 |
Padsevonil
Padsevonil (UCB-0942, UCB0942) is a potential anti-seizure agent that functions as a pre- and post-synaptic inhibitor.. |
1294000-61-5 |
DC10292 |
Pagoclone
Pagoclone is an active (+)-enantiomer of the racemate RP 59037. Pagoclone is a partial GABA(A) receptor agonist used for the treatment of panic and anxiety disorders. |
133737-32-3 |
DC10255 |
Parecoxib
Parecoxib is a selective COX2 inhibitor. |
198470-84-7 |