Cat. No. | Product name | CAS No. |
DC70983 |
(R)-MLT-985
(R)-MLT-985 (compound 11) is a potent MALT1 protease inhibitor with an IC50 of 3 nM. (R)-MLT-985 has an IC50 of 20 nM for MALT1-dependent IL-2 production in Jurkat cells. (R)-MLT-985 suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells. |
1832577-07-7 |
DC71173 |
PF-184
PF-184 is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. PF-184 has anti-inflammatory effects. |
1187460-81-6 |
DC71397 |
R-HP210
R-HP210 acts on the NF-κB mediated tethered transrepression function (IC50=3.80 μM). R-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. R-HP210 does not induce the transactivation functions of Glucocorticoids (GCs). |
|
DC71398 |
HSR1304
HSR1304 (Compound 5d) is a potent inhibitor of NFκB. The multifunctional transcription factor, nuclear factor-κB (NF-κB), is broadly involved in multiple human diseases, such as cancer and chronic inflammation. HSR1304 has the potential for the research of cancer diseases. |
2763363-08-0 |
DC71677 |
IMD-0560
Featured
IMD-0560 is an Inhibitor of nuclear factor kappa-B kinase (IKK) which can suppress the production of inflammatory cytokines and chemokines. |
439144-66-8 |
DC71825 |
Chitosan oligosaccharide
Featured
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways. |
148411-57-8 |
DC72126 |
(Rac)-PF-184 hydrate
(Rac)-PF-184 hydrate is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. (Rac)-PF-184 hydrate has anti-inflammatory effects. |
|
DC72232 |
NVS-MALT1
NVS-MALT1 is a MALT1 allosteric inhibitor. |
|
DC72264 |
DMX-129
DMX-129 is an ΙΚΚε and TBK-1 inhibitor with IC50 values of <30 nM for both TBK1 and IKKε. |
1623123-95-4 |
DC72411 |
RGT-068A
RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor. |
2577171-33-4 |
DC72412 |
Laurotetanine
Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways. |
128-76-7 |
DC72413 |
Dehydromiltirone
Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research. |
116064-77-8 |
DC72804 |
Z-VRPR-FMK
Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression. |
1381885-28-4 |
DC73798 |
MLT-827
MLT-827 is a potent and selective inhibitor of MALT1 paracaspase activity with IC50 of 5 nM. |
2682102-03-8 |
DC73799 |
MLT-943
MLT-943 is a potent and selective MALT1 protease inhibitor with IC50 of 40 nM in IL-2 reporter gene assay (Jurkat T cells), inhibits human PBMC IL-2 release with IC50 of 74 nM. |
1832576-04-1 |