Cat. No. | Product name | CAS No. |
DC24177 |
Mitiglinide calcium hydrate
Featured
An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells. |
207844-01-7 |
DC24164 |
Proparacaine hydrochloride
An irreversible local anesthetic. |
5875-06-9 |
DC11640 |
PK-11195
Featured
PK 11195 is a ligand of translocator protein. It targets Leishmania chemotherapy (IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively). |
85532-75-8 |
DC22576 |
MSI-1436
An non-competitive, allosteric inhibitor of PTP1B with Ki of 0.6 uM for PTP1B1-405. |
186139-09-3 |
DC11911 |
Rovazolac
Featured
Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1. |
1454288-88-0 |
DC22997 |
BI-653048
An oral glucocorticoid agonist for the treatment of rheumatoid arthritis.. |
1198784-97-2 |
DC24069 |
CI-947
Featured
An orally active adenosine receptor agonist that can induce acute cardiovascular toxicity and coronary vascular injury in vivo.. |
96392-15-3 |
DC23721 |
Metribolone
An orally active anabolic-androgenic steroid and a 19-nortestosterone derivative that has been widely used in scientific research as a hot ligand in androgen receptor (AR) ligand binding assays (LBAs) and as a photoaffinity label for the AR.. |
965-93-5 |
DC11934 |
LQB-118
An orally active pterocarpanquinone that exhibits antitumoral and antileishmanial activity both in vitro and in vivo. |
1219104-20-7 |
DC24141 |
Lexibulin dihydrochloride
An orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo. |
917111-49-0 |
DC23019 |
PACMA 31
Featured
An orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI. |
1401089-31-3 |
DC22713 |
L-733060
An orally active, non-peptide, selective antagonist for the NK1 receptor with Ki of 0.8 nM. |
148700-85-0 |
DC22690 |
L-733060 hydrochloride
An orally active, non-peptide, selective antagonist for the NK1 receptor with Ki of 0.8 nM. |
148687-76-7 |
DC21705 |
STX-213
An orally active, second-generation steroid sulfatase inhibitor with IC50 of 0.5 nM. |
415974-72-0 |
DC22943 |
Laniquidar
An orally active, third-generation P-glycoprotein inhibitor that inhibits the drug efflux pump P-glycoprotein, resulting in higher concentrations of antineoplastic agents in tumor cells that are multi-drug resistant due to the overexpression of P-glycopro |
197509-46-9 |
DC11965 |
Lucanthone
An orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APE1) potential antineoplastic activity, also inhibits autophagy. |
479-50-5 |
DC22793 |
PF 04942847
An orally available, ATP-competitive, small-molecule inhibitor of HSP90 with Ki of 6 nM. |
1207961-33-8 |
DC21242 |
LM11A-31 dihydrochloride
Featured
An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors. |
1243259-19-9 |
DC20609 |
Elobixibat
An orally available, potent and selective ileal bile acid transporter (IBAT) inhibitor for the treatment of constipation.. |
439087-18-0 |
DC23854 |
Vorolanib
An orally available, small molecule dual VEGFR/PDGFR kinase inhibitor with antiangiogenic and antineoplastic activities. |
1013920-15-4 |
DC11738 |
SCYX-7158
An orally-active, CNS permeable benzoxaborole antiprotozoal agent. |
1266084-51-8 |
DC23240 |
Athidathion
An organophosphate insecticide agent.. |
19691-80-6 |
DC24132 |
Haloxon
An organophosphorus anthelmintic used against nematodes of the abomasum and small intestine in ruminants. . |
321-55-1 |
DC24008 |
Eperezolid
Featured
An oxazolidinone antibiotic that possesses potent antimicrobial activity in vitro and in vivo.. |
165800-04-4 |
DC22570 |
eN-IN-1
An α,β-Methylene-ADP (AOPCP) derivative, potent, selective ecto-5′-Nucleotidase (eN, CD73) inhibitor with Ki of 29 nM for rat recombinant eN. |
95523-13-0 |
DC20307 |
AN-12-H5
AN-12-H5 is a bifunctional, enviroxime-like anti-Enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection with EC50 of 0.55 uM. |
1193340-31-6 |
DC7061 |
AN-2690(Tavaborole)
AN-2690(Tavaborole), an antifungal agent with activity against Trichophyton species, in a topical solution formulation, for the potential treatment of onychomycosis. |
174671-46-6 |
DC12168 |
AN2718
AN2718 inhibits fungal growth by blocking protein synthesis using the oxaborole tRNA trapping (OBORT) mechanism. |
174672-06-1 |
DC23543 |
ANA975
ANA975 is an oral prodrug of the TLR-7 agonist Isatoribine (ANA245. |
847453-47-8 |
DC9429 |
Anagliptin
Anagliptin is a potent and selective DPP-4 inhibitor(IC50= 3.8 nM); > 10 fold less potent for DPP-8 and DPP-9. |
739366-20-2 |
DC9580 |
Anagrelide (hydrochloride)
Anagrelide Hydrochloride(BL4162A) is a drug used for the treatment of essential thrombocytosis. |
58579-51-4 |
DC11649 |
Jamaicin (AnCoA4)
Featured
AnCoA4 (AnCoA-4, AnCoA 4) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM. |
24211-36-7 |
DC20085 |
Androgen receptor modulators 1
Androgen receptor modulators 1 is a selective androgen receptor modulator (SARM). Androgen receptor modulators 1 has strong agonistic activities with an EC50 of 4.7 nM. |
1114546-03-0 |
DC12143 |
Anemarrhenasaponin I
Anemarrhenasaponin I, a traditional Chinese medicine, is isolated from Anemarrhena asphodeloides Bunge. |
163047-21-0 |
DC12113 |
Anemarsaponin E
Anemarsaponin E is extracted from Anemarrhena asphodeloides Bunge and has anti-inflammatory activity. |
136565-73-6 |
DC24123 |
Angiotensin 1-7
Angiotensin (1-7) (Ang-(1-7)) is an active heptapeptide of the Renin-angiotensin system (RAS), inhibits purified canine angiotensin converting enzyme (ACE) activity with IC50 of 0.65 uM. |
51833-78-4 |
DC9348 |
Angiotensin II human
Angiotensin II human is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. |
4474-91-3 |
DC24109 |
Anguizole
Anguizole is a HCV NS4B inhibitor targeting second amphipathic helix of NS4B (NS4B-AH2), blocks genotype 1b HCV replication with EC50 of 310 nM. |
442666-98-0 |
DC8241 |
Ansamitocin P-3
Featured
Ansamitocin P-3, a potent anti-tumor maytansinoid found in Actinosynnema pretiosum, is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. |
66584-72-3 |
DC20671 |
ANT431 sodium
ANT431 sodium is a novel, highly water-soluble metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively). |
|
DC11088 |
Fosmanogepix
antifungal. |
2091769-17-2 |
DC23276 |
Antimalarial compound 49c
Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM. |
1422207-75-7 |
DC20308 |
Antimycin A
Antimycin A is an inhibitor of cellular respiration, specifically oxidative phosphorylation, binds to the Qi site of cytochrome c reductase, disrupts the Q-cycle of enzyme turn over. |
1397-94-0 |
DC22094 |
ANY1
ANY1 (FosA inhibitor ANY1) is a small molecule active site inhibitor of FosA (metal-dependent glutathione S-transferase) with IC50 of 5.1 uM (K. pneumoniae FosA). |
482574-02-7 |
DC10950 |
AOH1160
AOH1160 is a potent, first-in-class, orally available small molecule inhibitor of Proliferating cell nuclear antigen (PCNA). |
2089314-57-6 |
DC11196 |
AP14145
AP14145 (AP-14145) is a potent, selective negative allosteric modulator of KCa2.2 and KCa2.3 with equal potency (IC50=1.1±0.3 uM). |
1446770-54-2 |
DC20078 |
AP1867
Featured
AP1867 is a synthetic FKBP12F36V-directed ligand. |
195514-23-9 |
DC22207 |
AP1903
Featured
AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM. |
195514-63-7 |
DC8581 |
AP219
AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H2S-releasing portion. |
779282-36-9 |
DC1020 |
Ponatinib (AP24534)
Featured
AP24534 is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively. |
943319-70-8 |
DC5198 |
ALK-IN-1 (Brigatinib analog)
Featured
ALK-IN-1 (Brigatinib analog) is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK), Patent US20140066406 A1. |
1197958-12-5 |
DC12705 |
APA modulator T4
APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts. |
785708-33-0 |
DC12706 |
APA modulator T5
APA modulator T5 is a small modulator of alternative polyadenylation (APA), modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts. |
1293394-50-9 |
DC12636 |
Apararenone
Featured
Apararenone (MT-3995) is a novel potent, selective non-steroidal mineralocorticoid receptor antagonist for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.. |
945966-46-1 |
DC20310 |
Apcin
Featured
Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates. |
300815-04-7 |
DC11428 |
Olorinab
APD-371 (APD371, Olorinab) is a potent, selective and orally available CB2 agonist with EC50 of 6.2 nM; displays no activity against CB1 receptors (EC50>10 uM); exhibits activity in rat model of osteoarthritis pain. |
1268881-20-4 |
DC22430 |
APD916
APD916 is a potent and selective antagonist of the H3 receptor with Ki of 0.7 nM for rH3R. |
1021169-11-8 |
DC11077 |
Azelaprag
apelin receptor. |
2049980-18-7 |
DC21448 |
Apicidin
Featured
Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay. |
183506-66-3 |
DC23406 |
Aplaviroc
Aplaviroc (GSK-873140. |
461443-59-4 |
DC23522 |
Aplaviroc HCl
Featured
Aplaviroc, also known as AK-602; GW-873140; GW873140A; ONO-4128, is a CCR5 entry inhibitor for the potential treatment of HIV infection. Aplaviroc (GW873140) binds specifically to human cellular CC chemokine receptor 5 (CCR5) and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In vitro studies show that aplaviroc selectively inhibits the binding of a particular monoclonal antibody, 45531, to CCR5. |
461023-63-2 |
DC25100 |
Apogossypol
Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively. |
66389-74-0 |
DC23901 |
R-(-)-Apomorphine
Featured
Apomorphine hydrochloride hemihydrate is a non-selective dopamine agonist which activates both D1-likeand D2-like receptors, with some preference for the latter subtypes.. |
41372-20-7 |
DC7003 |
Apricitabine
Apricitabine is a novel nucleoside reverse transcriptase inhibitor for the treatment of HIV infection that is refractory to existing drugs |
160707-69-7 |
DC11513 |
Aprocitentan (ACT-132577)
Featured
Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of macitentan, which is dual ETA/ETB antagonist designed for tissue targeting. |
1103522-45-7 |
DC10207 |
Aprotinin
Aprotinin is a serine protease inhibitor isolated from bovine lung which inhibits trypsin and chymotrypsin with Ki values of 0.06 pM and 9 nM, respectively. |
9087-70-1 |
DC8664 |
APTO-253
APTO-253 is a novel small molecule with potent anti-tumor activity in cancer cells via induction of the gene that expresses the Krüppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death. |
916151-99-0 |
DC21999 |
APTO-253 hydrochloride
APTO-253 is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels. |
1422731-37-0 |
DC20672 |
APX001A
Featured
APX001 (APX 001A;E1210) is a novel broad-spectrum antifungal agent that inhibits the fungal protein Gwt1, demonstrates significantly acitive MIC50 and MIC90 values of 0.004 and 0.031 ug/ml (16 strains of C. auris). |
936339-60-5 |
DC11809 |
APX-115
Featured
APX-115 (Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively. |
1270084-92-8 |
DC11194 |
APX2009
APX2009 (APX-2009) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.45 uM for redox EMSA inhibition. |
1415030-15-7 |
DC11195 |
APX2014
APX2014 (APX-2014) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.2 uM for redox EMSA inhibition. |
1415030-17-9 |
DC23311 |
AQ-101
AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53. |
1353384-61-8 |
DC12155 |
AQ-13 dihydrochloride
AQ-13 dihydrochloride is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum. |
169815-40-1 |
DC20673 |
AQW-051
AQW-051 is a novel, potent and selective, orally bioavailable, brain-penetrant α7 nAChR partial agonist with pKd of 7.56. |
669770-29-0 |
DC23139 |
AQX 1125
AQX 1125 (Rosiptor) is a specific, orally bioavailable SHIP1 activator. |
782487-28-9 |
DC20674 |
AR03
AR03 (AR-03, AR 03, Ape1 repair inhibitor 03) is a novel small molecule inhibitor of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) endonuclease activity with IC50 of 5 uM. |
510721-85-4 |
DC22493 |
ARA-290(Cibinetide)
Featured
ARA-290 (Cibinetide) is a non-erythropoietic erythropoietin (EPO) derivative. |
1208243-50-8 |
DCAPI1051 |
Arbidol HCl (Umifenovir)
Featured
Umifenovir is currently being investigated as a potential treatment and prophylactic agent for COVID-19 caused by SARS-CoV2 infections in combination with both currently available and investigational HIV therapies. Arbidol hydrochloride (Umifenovir hydroc |
131707-23-8 |
DC20675 |
AR-C102222
AR-C102222 is a potent, selective iNOS inhibitor with IC50 of 35 nM, dislapys 3,000-fold and 20-fold selectivity over eNOS and nNOS respectively. |
253771-21-0 |
DC22544 |
AR-C155858
AR-C155858 is a potent monocarboxylate transporter MCT1 and MCT2 with Ki of 2.3 nM and <10 nM, displays no activity at MCT4. |
496791-37-8 |
DC12359 |
Arg-AMS
Arg-AMS is a potent nanomolar inhibitor of arginyl tRNA synthetase, which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes. |
301351-95-1 |
DC9487 |
Arg-Gly-Asp-Ser
Featured
Arg-Gly-Asp-Ser(RGDS peptide) is an integrin binding sequence that inhibits integrin receptor function; decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS |
91037-65-9 |
DC23605 |
AR-HO47108
AR-HO47108 is a potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 7.0. |
248281-68-7 |
DC20677 |
ARN 077
ARN077 is the first potent, selective N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 7 nM on both rat NAAA and human NAAA. |
1373625-34-3 |
DC12569 |
ARN14494
ARN14494 (ARN-14494) is a potent, small molecule serine palmitoyltransferase (SPT) inhibitor with IC50 of 27.3 nM. |
1037837-27-6 |
DC22000 |
ARN19874
ARN19874 (ARN-19874) is the first selective, cell-active inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) with IC50 of 33.7 uM. |
2190502-57-7 |
DC20676 |
ARN-3261
ARN-3261 is a potent, selective, orally available salt inducible kinase SIK2 and SIK3 inhibitor with IC50 of 11 nM and 19 nM, respectively. |
|
DC20678 |
ARN 726
ARN726 is a potent, selective, orally bioavailable N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 63 nM (r-NAAA) and 27 nM (h-NAAA). |
1628343-77-0 |
DC12460 |
ARP101
ARP101 (ARP-101) is a selective MMP-2 inhibitor, induces autophagy-associated cell death in cancer cells. |
849773-63-3 |
DC9972 |
ARQ-092(Miransertib)
Featured
ARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). |
1313881-70-7 |
DC7820 |
ARQ 621
Featured
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1. |
1095253-39-6 |
DC8486 |
Varlitinib(ARRY-334543)
ARRY-334543 is a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases. |
845272-21-1 |
DC20679 |
ARRY-502
ARRY-502 is an orally bioavailable, potent and selective antagonist of the prostaglandin D2 receptor (CRTh2) for treatment of mild to moderate Th2-driven asthma.. |
1202891-16-4 |
DC8181 |
Filanesib(ARRY-520)
Featured
ARRY-520 is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM. |
885060-09-3 |
DC9495 |
ARRY-520 (R enantiomer)
ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM. |
885060-08-2 |
DC21452 |
Artefenomel
Artefenomel (OZ439) is a novel, next-generation antimalarial ozonide that demonstrates high potentcy against P. falciparum in vitro and P. berghei in vivo (K1/NF54, IC50=2.0/3.2 nM).. |
1029939-86-3 |
DC21451 |
Arterolane
Arterolane (OZ277. |
664338-39-0 |
DC12024 |
ARV-825
Featured
ARV-825 is a BRD4 Inhibitor based on PROTAC technology. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respectively. |
|
DC12614 |
Arylsulfonamide 64B
Arylsulfonamide 64B (HIF inhibitor 64B) is a small molecule HIF pathway inhibitor, blocks hypoxia-induced expression of c-Met and CXCR4 and uveal melanoma (UM) cell migration. |
1342890-83-8 |
DC20687 |
AS 2553627
AS 2553627 (AS2553627) is a novel potent, selective pan-JAK inhibitor with IC50 of 0.46, 0.30, 0.14 and 2.0 nM for JAK1, JAK2, JAK3 and TYK2, respectively. |
1251906-07-6 |
DC8256 |
AS 602801(Bentamapimod)
Featured
AS 602801(Bentamapimod) is a novel, orally active inhibitor of JNK. |
848344-36-5 |
DC22001 |
AS-1269574
Featured
AS-1269574 is a selective, orally available GPR119 agonist with EC50 of 2.5 uM in cell-based cAMP assays. |
330981-72-1 |
DC22002 |
AS1928370
AS1928370 (ASP8370) is a potent, selective, orally available TRPV1 antagonist with IC50 of 0.51 uM, shows no inhibitory effects on TRPV4, TRPA11, and TRPM8 at 10 uM. |
1345614-89-2 |
DC22766 |
AS-1949490
AS-1949490 (AS1949490) is a potent, selective SHIP2 inhibitor with IC50 of 0.34/0.62 uM for mouse/human SHIP2. |
1203680-76-5 |
DC20682 |
AS2521780
AS2521780 is a potent, selective, orally bioavailable PKCθ inhibitor that inhibits combinant human PKCθ enzyme with IC50 of 0.48 nM, >30-fold higher than other PKC isoforms. |
1214726-89-2 |
DC3112 |
AS-252424
Featured
AS-252424 is a novel, potent and selective inhibitor of PI3Kγ with IC50 of 33 nM. |
900515-16-4 |
DC20683 |
AS2541019
AS2541019 is a novel potent, selective, orally active PI3Kδ inhibitor with IC50 of 20.1 nM, >100-fold selectivity over other PI3K isoforms. |
2098906-98-8 |
DC20684 |
AS2677131
AS2677131(AS 2677131, AS-2677131) is a novel potent, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=4 nM). |
2171502-44-4 |
DC20035 |
AS2717638
Featured
AS2717638 is an oral active lysophosphatidic acid receptor 5 (LPA5) antagonist in rodents. AS2717638 also significantly improves PGE2-, PGF2α-, and AMPA-induced allodynia. |
2148339-28-8 |
DC7068 |
AS605240
AS-605240 is a potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC50 = 8 nM). AS-605240 displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα. |
648450-29-7 |
DC11407 |
Asapiprant(BGE-175)
Featured
Asapiprant (BGE-175) is a potent and specific antagonist of human PGD2/PTGDR signaling with Ki of 0.44 nM. BGE-175 is currently in a Phase 2 clinical trial to test whether it can prevent disease progression and mortality in older patients hospitalized wit |
932372-01-5 |
DC20622 |
Asciminib
Featured
Asciminib (ABL-001) is a potent and selective allosteric ABL1 inhibitor with IC50 of 0.25 nM in BCR–ABL1-transformed BaF3 cells. |
1492952-76-7 |
DC4169 |
ASC-J9
ASC-J9, is antitumor agent. ASC-J9 suppresses castration-resistant prostate cancer growth via degradation of full-length and splice variant androgen receptors. |
917813-54-8 |
DC21100 |
Gusacitinib (ASN-002)
Featured
ASN-002 (Gusacitinib, ASN002) is a novel and potent dual inhibitor of SYK/JAK kinases with IC50 of 5-46 nM in biochemical assays. |
1425381-60-7 |
DC20109 |
ASP-4058
ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. |
952565-91-2 |
DC23457 |
ASP6432
ASP6432 (ASP-6432) is a potent and selective antagonist of LPA1 receptor, does-dependently inhibits LPA-stimulated increase in intracellular calcium ion with IC50 of 11 nM. |
1282549-08-9 |
DC20693 |
ASP9436
ASP9436 (ASP-9436) is a potent, selective brain penetrant and orally active phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 8.0 nM, >420-fold selectivity over other PDE subtypes. |
1401807-89-3 |
DC22003 |
Aspacytarabine
Aspacytarabine (Astarabine, BST236) is a cytarabine conjugate that shows anti-neoplastic agents for inhibiting cancer cell growth. . |
2098942-53-9 |
DC12360 |
Asp-AMS
Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme. |
828288-98-8 |
DC7360 |
AST-1306
AST-1306 is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases. |
1050500-29-2 |
DC11163 |
AST-3424
Featured
AST-3424 (OBI-3424, TH-3424) is a first-in-class, novel prodrug that selectively targets cancers overexpressing the enzyme AKR1C3, OBI-3424 is a highly selective prodrug that is converted by AKR1C3 to a DNA alkylating agent. |
2097713-68-1 |
DC20148 |
Astaxanthin
Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is an inhibitor of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. Astaxanthin has potential in the treatment of various di |
472-61-7 |
DC23804 |
Astex ERK inhibitor X
Astex ERK inhibitor X is a novel potent ERK1/2 inhibitor that inhibits ERK catalytic activity with IC50 of 3 nM in TRK kinase assays. |
2095719-90-5 |
DC12617 |
Astin C
Astin C is a cyclopeptide isolated from the medicinal plant Aster tataricus, inhibits cGAS-STING signaling and the innate inflammatory responses triggered by cytosolic DNAs, inhibits intracellular DNA-induced Ifnb expression with IC50 of 3.42 and 10.83 uM |
148057-23-2 |
DC12126 |
Astragaloside VI
Astragaloside VI could activate EGFR/ERK signalling pathway to improve wound healing. |
84687-45-6 |
DC20696 |
ASTX660 hydrochloride
ASTX660 hydrochloride is a novel potent IAP antagonist that targets the BIR3 domain of cIAP1/2 and XIAP with IC50 of 12 nM and <40 nM. |
1799328-50-9 |
DC20695 |
ASTX660(Tolinapant)
Featured
ASTX660 is a novel potent IAP antagonist that targets the BIR3 domain of cIAP1/2 and XIAP with IC50 of 12 nM and <40 nM. |
1799328-86-1 |
DC20697 |
ASTX660 mesylate
ASTX660 mesylate is a novel potent IAP antagonist that targets the BIR3 domain of cIAP1/2 and XIAP with IC50 of 12 nM and <40 nM. |
1799328-90-7 |
DC7361 |
Asunaprevir
Featured
Asunaprevir (BMS-650032) is a potent hepatitis C virus (HCV) NS3 protease inhibitor. |
630420-16-5 |
DC22401 |
AT-090
AT-090 is a novel potent, selective nociceptin/orphanin FQ receptor (NOP receptor) agonist with Ki of 5.61 nM. |
2099681-59-9 |
DC20080 |
AT-1002
Featured
AT-1002, a 6-mer synthetic peptide, is a tight junction regulator and absorption enhancer. |
835872-35-0 |
DC2015 |
AT-101 (AT101)
AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members. |
866541-93-7 |
DC20699 |
AT-130
Featured
AT-130 is a potent inhibitor of HBV capsid assembly, inhibits wild-type HBV replication with IC50 of 2.4 uM. |
211364-06-6 |
DC20698 |
AT-403
AT-403 (AT403) is a potent, highly selective, nonpeptide NOP agonist with pEC50 of 9.45. |
|
DC9395 |
AT7519 (trifluoroacetate)
AT7519 trifluoroacetate is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM; less potent to CDK3 and little active to CDK7. |
1431697-85-6 |
DC9336 |
AT7867 (dihydrochloride)
AT7867 Hcl is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family. |
1431697-86-7 |
DC23554 |
AT791
AT791 is a novel orally available, small molecule inhibitor of TLR7 and TLR9 with IC50 of 3.33 uM and 0.04 uM respectively, inhibits DNA-TLR9 interaction in vitro. |
1219962-49-8 |
DC11889 |
Atabecestat
Featured
Atabecestat (JNJ-54861911, JNJ54861911) is a novel potent, oral beta-secretase (BACE) inhibitor for treatment of Alzheimer's Disease. |
1200493-78-2 |
DC21122 |
Ataciguat sodium
Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC. |
254976-06-2 |
DC21121 |
Ataciguat
Featured
Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC. |
254877-67-3 |
DC23606 |
Atagabalin
Atagabalin (PD 0200390) is a novel ligand of the voltage-dependent calcium channel (VDCC) α2δ subunit (1 and 2) for treatment for insomnia.. |
223445-75-8 |
DC9480 |
Atazanavir (sulfate)
Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor. |
229975-97-7 |
DC10921 |
ATH686
Featured
ATH686 (ATH-686) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase. |
853299-52-2 |
DC9878 |
ATI-2341
ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. |
1337878-62-2 |
DC21656 |
Atiprimod
Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways. |
123018-47-3 |
DC21657 |
Atiprimod dihydrochloride
Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways. |
130065-61-1 |
DC20033 |
ATM Inhibitor-1
ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibitor, with an IC50 of 0.7 nM, shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50, 10.3 μM), PI3Kγ (IC50, 3 μM) and PI3Kδ (IC50, 0 |
2135639-94-8 |
DC12627 |
ATM-3507
ATM-3507 (ATM3507) is a small molecule inhibitor of Tpm3.1 tropomyosin isoform, disrupts Tpm3.1-containing microfilaments in SK-N-SH cells at 5 uM. |
1861449-70-8 |
DC7709 |
ATN-161
Featured
ATN-161 is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model. |
262438-43-7 |
DC23607 |
Atomoxetine
Atomoxetine ((R)-Tomoxetine. |
83015-26-3 |
DCAPI1390 |
Atovaquone (Atavaquone)
Featured
Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia. |
95233-18-4 |
DC11095 |
ATR-101 free base
ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM. |
133825-80-6 |
DC22775 |
ATR-101
ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM. |
133825-81-7 |
DC22004 |
ATV399
ATV399 (ATV-399) is a novel small molecule that dose-dependently reduces the cleaved caspase9 levels with IC50 of 3.3 uM, inhibits dimerization of iNOS. |
393834-37-2 |
DC20114 |
ATWLPPR Peptide TFA
ATWLPPR Peptide TFA, a heptapeptide, acts as a selective neuropilin-1 inhibitor, inhibits VEGF165 binding to NRP-1, used in the research of angiogenesis. ATWLPPR Peptide TFA has potential in reducing the early retinal damage caused by diabetes. |
|
DC23401 |
AU1
AU1 (GSK 1379725A) is the first selective small molecule inhibitor of BPTF bromodomain (bromodomain PHD finger transcription factor) with Kd of 2.8 uM in a cell-based reporter assay, shows no binding activity for Brd4. |
1802251-00-8 |
DC21865 |
Aumitin
Featured
Aumitin is a novel potent autophagy inhibitor with IC50 of 124 and 244 nM against starvation- and rapamycin- induced autophagy respectively, targets mitochondrial complex I. |
946293-78-3 |
DC26036 |
Aurantiamide acetate
Aurantiamide acetate suppresses the growth of malignant gliomas in vitro and in vivo by inhibiting autophagic flux. |
56121-42-7 |
DC20312 |
Aurintricarboxylic acid
Aurintricarboxylic acid (ATA) is a potent small molecule inhibitor of RISC loading with IC50 of 0.47 uM, inhibits RISC activity against transiently expressed reporters and endogenous genes. |
4431-00-9 |
DC20037 |
Aurora inhibitor 1
Aurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase, respectively. |
2227019-45-4 |
DC26118 |
AKI-7169(Aurora Kinase Inhibitor III)
Featured
Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase (IC50 = 42 nM). |
879127-16-9 |
DC11999 |
AUT-1
Featured
AUT-1 is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively. |
1311136-84-1 |
DC21866 |
Autotaxin inhibitor 12
Autotaxin inhibitor 12 is a highly potent, selective, orally-bioavailable inhibitor of autotaxin with IC50 of 3.1 nM in choline release assays. |
1613513-14-6 |
DC20701 |
Autotaxin inhibitor compound 1
Autotaxin inhibitor compound 1 (Autotaxin-IN-1) is a potent, selective, orally bioavailable inhibitor of autotaxin with IC50 of 2.2 nM in ex vivo human whole blood assay, does not inhibit related proteins ENPP1 and ENPP7. |
1619971-30-0 |
DC22219 |
Auxin agonist RN3
Auxin agonist RN3 (RubNeddin 3) is a potent, selective auxin agonist that induces specific AUX/IAA protein degradation to modulate plant development. |
425609-03-6 |
DC22220 |
Auxin agonist RN4
Auxin agonist RN4 (RubNeddin 4) is a potent, selective auxin agonist that induces specific AUX/IAA protein degradation to modulate plant development. |
433950-87-9 |
DC8253 |
AV-412(MP-412)
AV-412(MP-412) is a potent dual inhibitor of EGFR and ErbB2(IC50=19 nM) tyrosine kinases, including the mutant EGFR(L858R IC50=0.51 nM, T790M IC50=0.79 nM); inhibits autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively. |
451492-95-8 |
DC22012 |
Avanbulin
Avanbulin (BAL27862, BAL-27862) is a novel microtubule-destabilizing agent that potently inhibits tubulin assembly at 37°C with IC50 of 1.4 uM in tubulin-binding assays. |
798577-91-0 |
DC20703 |
AVE-0118
AVE-0118 is a potent I(to)/I(Kur) blocker, Kv1.5 channel inhibitor with IC50 of 5.6 uM, also blocks Kv1.3, Kv2.1, Kv3.1, and Kv4.3 channels with similar potency. |
498577-53-0 |
DC12715 |
AVG-233
AVG-233 (AVG233) is a potent, allosteric inhibitor of respiratory syncytial virus (RSV) RNA-dependent RNA polymerase (RdRp) complex, demonstrates nanomolar activity against both laboratory-adapted RSV strains and clinical RSV isolates (EC50=34-79 nM). |
2151937-80-1 |
DC24068 |
AVL-292 besylate
Featured
AVL-292 besylate (Spebrutinib, CC-292) is a highly selective, covalent Btk inhibitor with IC50 of <1 nM. |
1360053-81-1 |
DC9436 |
Avosentan
Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist. |
290815-26-8 |
DC20709 |
AW-814141
AW-814141 is a potent, selective and orally active inhibitor of p38 MAP kinase with IC50 of 100 nM/158 nM for p38α/p38β. |
905285-51-0 |
DC11802 |
AX-024 free base
Featured
AX-024 is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A. |
1370544-73-2 |
DC10412 |
AX20017
Featured
AX20017 is a small-molecule protein kinase G (PknG) inhibitor with an IC50 of 0.39 μM. |
329221-38-7 |
DC20313 |
Axl-IN-21
Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM. |
2086274-31-7 |
DC23895 |
AY-9944
Featured
AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol. |
366-93-8 |
DC23879 |
AZ 4800
AZ 4800 is a potent γ-secretase modulator that reduces Aβ40 and Aβ42 levels in HEK/APPswe cells with IC50 of 26 nM and 60 nM, also decreases Aβ39, whereas increases both Aβ37 and Aβ38.. |
1226886-78-7 |
DC7367 |
AZ-960
Featured
AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of <3 nM and 0.45 nM, 3-fold selectivity of AZ960 for JAK2 over JAK3. |
905586-69-8 |
DC20710 |
AZ0108
AZ0108 is an orally bioavailable phthalazinone PARP inhibitor with enzyme IC50 of <30/<30/83 nM for PARP1/2/6 respectively. |
1825345-52-5 |
DC11147 |
AZ084
AZ084 (AZ-084) is a potent, selective, allosteric, orally available CCR8 antagonist with Ki of 0.9 nM. |
929300-19-6 |
DC20314 |
AZ-1
AZ-1 is a small molecule inducer of ABCA1 and apoE that act through indirect activation of the LXR pathway, shows purinergic receptor P2X7 antagonist activity. |
803735-54-8 |
DC11975 |
AZ 10397767
AZ10397767 is a potent, selective CXCR2 inhibitor that inhibits CXCL8 binding to CXCR2 with pIC50 of 9.0. |
333742-63-5 |
DC20711 |
AZ10606120 dihydrochloride
Featured
AZ10606120 is a potent, specific P2X7 receptor antagonist with Kd of 1.4 and 19 nM at human and rat P2X7 receptors respectively. |
607378-18-7 |
DC12613 |
AZ12204657
AZ12204657 (AZ-12204657) small-molecule GPR44 antagonist, displaces the binding of [3H]PGD2 from membranes of HEK293 cells transfected with human recombinant GPR44 with IC50 of 2.5 nM. |
847148-49-6 |
DC22724 |
AZ12441970
AZ12441970 is a selective TLR7 agonist with pEC50 of 6.8 and 6.6 for human and rat TLR7, shows inactivity against TLR8. |
929551-91-7 |
DC12530 |
AZ12601011
AZ12601011 (AZ-12601011) is a potent, selective inhibitor of ALK4, ALK7 and TGFBR1 (Kd=2.9 nM), inhibits TGFβ-induced reporter activity with IC50 of 18 nM. |
|
DC12531 |
AZ12799734
AZ12799734 (AZ-12799734) is a pan BMP/TGFβ inhibitor that potently inhibits ligand activated SMAD3/4 transcription with IC50 of 47 nM, inhibits receptor-mediated phosphorylation of SMAD1 by ALK1, BMPR1A and BMPR1B and phosphorylation of SMAD2 by ALK4, TGF |
1117684-36-2 |
DC21406 |
AZ-1355
AZ-1355 is an effctive lipid-lowering compound that inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro.. |
75451-07-9 |
DC20712 |
AZ13705339
Featured
AZ13705339 is a potent, selective PAK1 inhibitor with IC50 of 0.33 nM, displays 14-, 470-, 4100- and 2600-fold selectivity over Src, FGFR1, KDR and PAK4. |
2016806-57-6 |
DC20713 |
AZ13711265
AZ13711265 is a potent, selective, in vivo active PAK1 inhibitor with IC50 of 0.58 nM, displays 880-, 2100- and 90-fold selectivity over Src, FGFR1, KDR and PAK4. |
2016806-55-4 |
DC23484 |
AZ1729
AZ1729 is a novel direct, positive allosteric modulator of fatty acid receptor FFA2 (pEC50=6.9), selectively activates Gi signaling but lacks the capacity to activate FFA2 Gq/G11-mediated signaling pathways. |
2016864-46-1 |
DC20315 |
AZ-2
AZ-2 is a small molecule inducer of ABCA1 and apoE that act through indirect activation of the LXR pathway, shows purinergic receptor P2X7 antagonist activity. |
788146-30-5 |
DC23855 |
AZ-23
AZ-23 is a potent, selective, orally bioavailable Trk kinase inhibitor with IC50 of 2 and 8 nM for TrkA and TrkB, respectively. |
915720-21-7 |
DC20715 |
AZ-4217
AZ-4217 is a potent and selective, orally active, brain-permeable BACE1 inhibitor with IC50 of 160 pM in human SH-SY5Y cells. |
1383846-83-0 |
DC10985 |
AZ6197
AZ6197 (AZ-6197) is a potent, selective, reversible inhibitor of ERK1/2 with IC50 of <0.3 nM (ERK2), inhibits pERK/pRSK with IC50 of 12/62 nM in A375 cells, respectively. |
2023003-94-1 |
DC12274 |
AZ82
AZ82 is a selective HSET/KIFC1 inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1. |
1449578-65-7 |
DC11742 |
AZ-8838
AZ-8838 (AZ8838) is a potent, and selective PAR2 antagonist with Kd of 125 nM. |
2100285-41-2 |
DC23407 |
AZ8838 racemate
AZ8838 racemate(AZ-8838 racemate) is the racemate form of AZ8838, which is a potent, and selective PAR2 antagonist with Kd of 125 nM.. |
2100283-63-2 |