Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α.

Ac-WEAD-pNA is a colorimetric substrate for caspase-1 and caspase-4.

ACY-775 (ACY775) is a potent and specific HDAC6 inhibitor (IC50=7.5 nM) with improved brain bioavailability.

ACY-957 (ACY957) is a potent, selective inhibitor of HDAC1 and HDAC2 with IC50 of 7 and 18 nM, shows limited activity against HDAC3 (IC50=1,300 nM) and no activity against HDAC4/5/6/7/8/9 (IC50>20 nM).

Acyclovir (Aciclovir)

AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively.

AD80, a multikinase inhibitor, shows strong activity against human RET, BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.

ADAMTS-5 inhibitor 15f is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE.

ADAMTS-5 inhibitor 8 is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE.

Adarotene (ST1926) is an effective apoptosis inducer and surprisingly produced DNA damage.ST1926 exhibites a potent antiproliferative activity on a large panel of human tumor cells. IC50 value: 0.12 uM (LNCaP cell) [1] Target: Apoptosis inducer; Antican

ADC-3680 (PTR-36, ADC-3680B) is a potent, selective prostaglandin D2 receptor (DP2, CRTH2) antagonist for the treatment of asthma..

ADC-3680 is a potent, selective prostaglandin D2 receptor (DP2, CRTH2) antagonist for the treatment of asthma..

Adefovir Dipivoxil(Preveon, Hepsera) works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.

Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.

Adenosine 5'-monophosphate monohydrate (5'-AMP) is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK).

Adhesamine is a diaryldispirotripiperazine derivative that selectively targets cell-surface glycosaminoglycans, especially heparan sulfate, for increasing cell adhesion and growth.

AdipoRon hydrochloride is an orally active and specific AdipoR agonist, binding to AdipoR1 and AdipoR2, with Kds of 1.8 and 3.1 μM, respectively.

ADL5859 agonizes δ-opioid receptor with a 1000-fold selectivity than µ- or κ-opioid receptor with Ki of 32 nM and 37 nM, respectively.ADL5859 displays weak inhibitory activity at the hERG channel with an IC50 of 78 μM. The EC50 of ADL5859 against δ opioid

ADM 12 (ADM_12.

Adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties.

Adrenomedullin (AM) (1-52), human (TFA) affects cell proliferation and angiogenesis in cancer.

ADT-094 (ADT094) is a novel, non-COX inhibitory sulindac derivative that potently and selectivity inhibits colon tumor cell growth by inhibiting PDE5 and PDE10 with IC50 of 2.4 uM and 0.5 uM, respectively.

ADX-102 (Reproxalap, NS-2) is a novel small molecule immunomodulator that covalently binds aldehydes including malondialdehyde and 4-hydroxynonenal, which have been shown to mediate inflammatory pain; DX-102 is a promising agent for the treatment of dry eye disease.

AEE788 is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.

AF38469 is a potent, selective, orally bioavailable Sortilin inhibitor with IC50 of 330 nM, shows no activity against the NTR1 receptor as well as a panel of targets known to bind acidic molecules (δ-Opioid, GPR40, PPARδ, EP1, Angiotensin AT1, Endothelin

AF40431 (AF-40431) is the first reported small-molecule ligand of the VPS10P family sorting receptor Sortilin with IC50 of 4.4 uM, binds in the neurotensin-binding site of sortilin..

AF-792 (RO-5) is a novel selective P2X3 and P2X2/3 antagonist with pIC50 of 8.2 and 7.9 respectively, with no inhibition at other P2X receptors.

Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity.

AG13958 is a VEGF inhibitor that was clinical development by Pfizer in 2006-07 for treatment of age-related macular degeneration (AMD).

AG-24322 is a second generation CDK inhibitor. AG-024322 is a potent inhibitor of CDK1, CDK2, and CDK4 that produces cell-cycle arrest and antitumor activity in preclinical models. The no-adverse-effect dose of AG-024322 was 2 mg/kg and associated with ov

AG-270 is an allosteric, noncompetitive, first-in-class, reversible and orally active MAT2A inhibitor, with an IC50 of 14 nM.

Aganepag is a potent Prostanoid EP2 receptor agonist, with an EC50 of 0.19 nM, and shows no activity at EP4 receptor. Aganepag can be used in the research of wound healing, scar reduction, scar prevention and wrinkle treatment and prevention.

AGI-14100 (AGI14100) is a novel potent and selective, orally available IDH1 mutant inhibitor.

AGL-2263 is an insulin receptor (IR) blocker.

AGN 194310(VTP-194310) is a potent and selective pan-RARs agonist with Kd values of 3/2/5 nM for RARα/β/γ respectively.

AGN 210676 is a selective prostaglandin EP2 agonist extracted from patent US20070203222A1, Compound example 23, has an EC50 of 5 nM.

AGN192836 (AGN 192836) is a potent, selective α2 adrenergic (alpha 2-adrenoceptor) agonist with EC50 of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.

Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.

AGPS-IN-1a is a potent inhibitor of the ether lipid-generating enzyme alkyl-glycerone phosphate synthase (AGPS), selectively lowers ether lipid levels in several types of human cancer cells and impairs their cellular survival and migration..

AgrA inhibitor F19 is a small-molecule AgrA inhibitor that act as antivirulence agent against Gram-positive pathogens, blocks staphylococcal transcription factor AgrA from binding to its promoter and inhibits toxin and virulence factor transcription.

AHU-377 is an inhibitor of neprilysin with IC50 value of 5 nM.

AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays.

AIC246 is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.

AICAR phosphate (Acadesine, AICA Riboside, NSC 105823) is a selective AMPK activator in both hepatocytes and adipocytes.

AJM300 (AJM 300, AJM-300) is a novel potent, selective, oraaly available alpha 4 integrin antagonist fortreatment of active ulcerative colitis..

AK106-001616 (AK 106-001616) is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) with IC50 of 3.8 nM (human cPLA2 enzyme).

AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM.

AK778 (Col001) is a small-molecule compound that inhibits the interaction of Hsp47 with collagen, competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen triple helix. .

AKOS B018304 is an arylalkylidene derivative, with polar substitution at para-position.

AKR1C3 inhibitor KV-37 is a potent, isoform selective and metabolically stable inhibitor of Aldo-keto reductase 1C3 (AKR1C3) with IC50 of 66 nM, displays 109-fold selectivity over AKR1C2.

Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity.

AL-9 is a small molecule HCV replication inhibitor with EC50 of 0.29 and 0.75 uM for genotype 1b and 2a, inhibits purified PI4KIIIα with IC50 of 0.57 uM.

ALB-127158 is a potent (IC50=7 nM), selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) for treatment of obesity..

Albiglutide is a glucagon-like peptide-1 agonist (GLP-1 agonist).

ALDH1A inhibitor 673A (ALDH1Ai 673A) is a potent, selective, pan-ALDH1A inhibitor with IC50 of 246, 230 and 348 nM for ALDH1A1, ALDH1A2 and ALDH1A3, respectively.

ALDH3A1 inhibitor EN40 is a potent and selective, covalent, in vivo-active inhibitor of ALDH3A1 with IC50 of 2 uM, demonstrates no activity against ALDH1A3 and ALDH6A1 at 30 uM.

ALE-0540 is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively.

Alexamorelin is a synthetic growth hormone (GH) secretagogue.

Alfuzosin is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).

ALG1001 (Risuteganib, ALG-1001) is a first-in-class, RGD class oligopeptide that inhibits integrin receptors (αvβ3, αvβ5, and α5β1) associated with angiogenesis; ALG1001 inhibits an integrin-mediated pathway of the vitreoretinal interface, connecting the posterior aspect of the vitreous with the internal limiting membrane of the retina. In blocking this pathway, ALG-1001 helps to achieve vitreous breakdown and separation from the retina.

Alicapistat (ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential use in the treatment of Alzheimer's disease (AD).

Alizapride (MS 5080) is a dopamine D2 antagonist with prokinetic and antiemetic effects used in the treatment of nausea and vomiting..

Alizapride (MS 5080) is a dopamine D2 antagonist with prokinetic and antiemetic effects used in the treatment of nausea and vomiting..

Allitinib (AST-1306, ALS1306)) is a novel potent, selective irreversible EGFR and HER2 inhibitor with IC50 of 0.5 and 3 nM in cell-free assays.

ALLM (Calpain Inhibitor) is cell-permeable, peptide aldehyde inhibitor of calpains and cathepsins.

ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM).

ALLO-2 is a potent small molecule Smoothened (Smo) antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

Alloepipregnanolone, a pregnane with anesthetic, hypnotic, and sedative properties, interferes with the development of rapid tolerance to the anxiolytic effect of ethanol.

Allopregnanolone is a progesterone metabolite. Allopregnanolone is an allosteric modulator of the GABA receptor.

Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.

Allopurinol sodium is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol sodium can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].

Alloxazine is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.

all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

Almotriptan Malate is a 5-HT1B/1D-receptor agonist used to treat migraine.

Alobresib is a novel BET bromodomain inhibitor with antineoplastic activity..

Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist.

Alprazolam (D-65MT, U 31889) is a triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities.

ALS-22335 is an anti-virus compound.

ALS-8112 is a potent, selective RSV polymerase inhibitor, the 5'-triphosphate of ALS-8112 (ALS-8112-TP) inhibits RSV polymerase(IC50=20 nM) without appreciable inhibition of human DNA and RNA polymerases.

ALS-8176 (Lumicitabine) is the 3',5'-di-O-isobutyryl prodrug of ALS-8112 5'-triphosphate (ALS-8112-TP), which is a potent, selective RSV polymerase inhibitor with IC50 of 20 nM.

Alvimopan(LY 246736; ADL 8-2698) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.

Alvimopan(LY 246736; ADL 8-2698) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.

ALW-II-41-27 is a novel Eph receptor tyrosine kinase inhibitor, used for cancer treatment.

ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2).

ALX-1393 (ALX 1393, ALX1393) is a potent, specific GlyT2 inhibitor with Ki of <1 uM.

ALX-5407 is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM.

ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease.

AM 432 is potent, selective, orally active prostaglandin D2 receptor (DP2/CRTH2) antagonist with binding IC50 of 6 nM for hDP2.

AM-0216 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NFkB activity is NIK-dependent.

AM-0561 (AM0561) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 0.3 nM..

AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.

AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.

AM251 is a potent CB1 receptor antagonist (IC50 = 8 nM, Ki = 7.49 nM) that displays 306-fold selectivity over CB2 receptors; also potent GPR55 agonist (EC50 = 39 nM).

AM-5262 is a potent full GPR40 (FFA1) agonist with EC50 of 81 nM.

AM-6226 (AM6226) is a potent, selective, orally bioavailable GPR40 (FFA1) full agonist with EC50 of 0.12 uM.

AM-6538 (AM6538) is a potent, selective cannabinoid receptor CB1 antagonist with Ki of 5.1 nM..

AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively.

AM9405 (AM-9405) is novel potent, peripherally active cannabinoid type 1 (CB1) and 5-HT3 receptor agonist, inhibits the EFS-induced twitch contraction of the ileum and the colon with IC50 of 0.076 and 45.71 nM, respectively.

Amelubant (BIIL284) is a potent, long-acting, orally active leukotriene B4 (LTB4) receptor antagonist, inhibits LTB4-induced mouse ear inflammation with ED50 of 0.008 mg/kg (p.o.).

AMG 580 (AMG580) is a novel potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 0.13 nM.

AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.

AMG 853 is novel a CRTH2 and DP Dual Antagonist.

AMG-076 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with binding IC50 of 0.6 nM, with dramatically reduced hERG liability (IC50>5 uM).

AMG-1 is a potent inhibitor of human c-Met and RON with IC50 values of 4 and 9 nmol/L respectively.

AMG1694 is a potent, small molecule Glucokinase (GK)-GKRP (GK regulatory protein) disruptor, does not block the GK binding site directly.

AMG232 is a potent, selective and orally bioavailable inhibitor of MDM2−p53 interaction with IC50 value of 9.1 nM in EdU cells .

AMG-458 (AMG458) is a potent, selective, orally bioavailable c-Met inhibitor with Ki of 1.2 nM (human c-Met).

AMG-548 is a potent and selective inhibitor of p38α with Ki of 0.5 nM, dispalys weak inhibition for p38β (Ki=3.6 nM), and >5,000-fold selectivity over p38γ and p38δ; shows >1,000-fold selectivity over other 36 kinases, and is efficacious in acute and chro

AMG-579 is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM.

AMG7703 (4-CMTB, AMG-7703) is an allosteric, selective agonist of FFAR2 (GPR43)..

Amgen16 is a highly potent inhibitor of NF-κB inducing Kinase (NIK), example 294 in patent WO 2009158011 A1..

AMG-Tie2-1 is a highly potent, non-selective inhibitor of Tie-2 (IC50 <1 nM).

Amicarbazone(BAY-MKH3586; BAY314666) is a potent inhibitor of photosynthetic electron transport via binding to the Qb domain of photosystem II (PSII); herbicide with a broad spectrum of weed control.

Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM).

Aminopyridine 2 (MPO inhibitor AP-2) is a novel potent, selective, orally available inhibitor of Myeloperoxidase (MPO), inhibits MPO peroxidase activity in vitro and in human plasma with IC50 of 0.16 and 1.9 uM, respectively.

Amitriptyline is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain.

Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.

Amonafide(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.

Ampiroxicam(CP65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.

AMPK activator 991 is an allosteric AMPK activator, activates non-phosphorylated Thr172 AMPK in vitro binds to α1β1γ1 and α2β1γ1 with Kd of 0.13 and 0.17 uM, respectively..

AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle.

Ampkinone is a novel small molecule activator of AMPK, stimulates the phosphorylation of AMPK via indirect activation of AMPK in various cell lines (2.7-fold at 10 uM).

Ampreloxetine (TD-9855) is a potent monoamine reuptake inhibitor with pIC50 of 8.0, 8.6 and 6.8 for human NET, SERT, and DAT, respectively.

Amprenavir (Agenerase) is a HIV protease inhibitor(Ki=0.6 nM) used to treat HIV infection.

AMR-2 is a highly potent, orally active, triple reuptake inhibitor of SERT, NET, and DAT with IC50 of 3.0, 3.1, and 8.3 nM, respectively.

Amrubicin(SM-5887) is a novel anthracycline derivative for treatment of bladder carcinoma.

Amsacrine (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.

amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity. TAC-101 inhibits retinoblastoma-gene product (RB) phosphorylation and increases the presence of 2 cyclin-dependent kinase (CDK) inhibitors, resulting in cell cycle arrest. This agent also causes a cytotoxic decline in cyclin A and thymidylate synthase expression. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).For the detailed information of TAC-101, the solubility of TAC-101 in water, the solubility of TAC-101 in DMSO, the solubility of TAC-101 in PBS buffer, the animal experiment (test) of TAC-101, the cell expriment (test) of TAC-101, the in vivo, in vitro and clinical trial test of TAC-101, the EC50, IC50,and Affinity of TAC-101, Please contact DC Chemicals..

Amuvatinib hydrochloride (MP470 hydrochloride) is a multi-targeted receptor tyrosine kinases inhibitor, which inhibits c-Kit (D816V), c-Kit (D816H), c-Kit (V560G), c-Kit (V654A), PDGFRα (D842V), and PDGFRα (V561D) with IC50s of 950 nM, 10 nM, 34 nM, 127 n

AMXT-1501 (AMXT 1501, AMXT1501) is a novel potent polyamine transport inhibitor, synergistically reduces cell viability in NB cells in combination of with DFMO.

AMXT-1501 tetrahydrochloride (AMXT 1501, AMXT1501) is a novel potent polyamine transport inhibitor, synergistically reduces cell viability in NB cells in combination with DFMO.

AMZ30 is a potent, selective, covalent inhibitor of the serine hydrolase protein phosphatase methylesterase-1 (PME-1) with IC50 of 0.6 uM, >100-fold selectivity over other SHs.

An acetylcholinesterase (AChE) inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.

HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction[1].

An active metabolite of the selective estrogen receptor modulator (SERM) tamoxifen.

An adenosine A1 receptor agonist (EC50= 8.2 nM)..

An agent for the treatment of nephropathic cystinosis and an antioxidant.

An alkaloid of Hydrastis canadensis used in many dietary supplements intended to enhance the immune system.

Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%).

An allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assyas.

An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM.

An amine-reactive NHS ester that provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as that of protein, peptide, or small molecule amine.

An amino fatty acid antibiotic that is 10- to 100-fold more potent than cyclosporin A as an immunosuppressive agent of the immune response in vitro and in vivo.

An aminoglycoside antibiotic used in veterinary medicine..

An aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia. .

An analog of adenosine 5’-monophosphate that potently and selectively inhibits NEDD8-activating enzyme (NAE) with IC50 of 4.7 nM.

An analog of the natural compound Fumagillin that functions as a highly potent methionine aminopeptidase 2 (MetAP2) inhibitor.

An analog of thymoquinone that blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic..

An analogue of deoxyspergualin that has immunostimulating activity, promotes resistance to Candida albicans infection in mice..

An angiotensin II analog that is an agonist of AT1 angiotensin receptor..

An anthelmintic effective for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity.

An anthelmintic effective for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity.

An anthelmintic that has antibacterial and anthelmintic properties along with algaecide activity.

An anthelmintic that has antibacterial and anthelmintic properties along with algaecide activity.

An antiaggressive agent that acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor..

An antiaggressive agent that acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor..

An antibiotic used to treat a number of bacterial infections that acts by inhibiting proper cell wall synthesis..

An antibiotic used to treat a number of bacterial infections that acts by inhibiting proper cell wall synthesis..

An antibiotic used to treat a number of bacterial infections..

An anticancer phytochemical commonly found in black cumin.

An anticestodal agent, fungicide, germicide, and antimicrobial agent.

An antifungal agent that works by altering the permeability of the fungal cell wall.

An antifungal antibiotic that inhibits fatty acid synthase (FASN), also blocks cellular proliferation of KRAS-associated lung cancer cells.

An anti-infective, anti-bacterial agent.

An anti-inflammation agent..

An anti-inflammatory agent used in the treatment of osteoarthritis.

An antimalarial candidate that demonstrates potent blood-stage and transmission-blocking activity, shows potent ABS activity (IC50 <25 nM) against drug-sensitive 3D7 and multidrug-resistant Dd2 parasites.

Naphthoquine phosphate is a potent and orally active antimalarial agent. Naphthoquine phosphate has thorough killing function for various schizonts of plasmodia, including resistance of P. falciparum to Chloroquine.

MMAF-Ome belongs to ADC, and inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.

An antiprotozoal, antirheumatic and intrapleural sclerosing agent.

An antipsychotic agent with serotonin-S2 and dopamine-D2 antagonistic properties.

An antipsychotic agent with serotonin-S2 and dopamine-D2 antagonistic properties.

An antitrypansomal drug that also possesses antitumor activity.

An antiviral compound that inhibits attachment to cells, inhibits human rhinovirus type 14 (HRV14) replication..

An E3 ligand- Linker Conjugate for PROTAC..

An E3 ligase ligand-linker conjugate for PROTAC..

An E3 ligase ligand-linker conjugate for PROTAC..

An E3 ligase ligand-linker conjugate for PROTAC..

An E3 ligase ligand-linker conjugate for PROTAC..

An E3 ligase ligand-linker conjugate for PROTAC.

An E3 ligase ligand-linker conjugate for PROTAC...

LE135 is a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels.

An efficient prodrug of ampicillin with enhanced absorption and decreased side effects..

An enantiomer of Ibuprofen that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids.

An enantiomer of Ibuprofen that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form.

An endogenous DHA metabolite that promotes neurite growth, synaptogenesis, and synaptic function both in vitro and in vivo.

Iperoxo is a superagonist of the muscarinic acetylcholine receptors and an OxotremorineM analog.

An imidazoacridinone analogue with potent in vivo antitumour activity, inhibits the catalytic activity of Topoisomerase II.

An imidazolinone herbicide that effectively controls a broad spectrum of weed species..

An immunoactive peptide that has been shown to inhibit cell proliferation and induce apoptosis in human leukemia, non-small cell lung cancer, melanoma, and other human cancers.

IRES-J007 ia an improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.

An impurity of Roflumilast, which is a selective and long-acting inhibitor of PDE-4 with IC50 value of 0.8 nM..

An indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells, directly inhibits Src kinase activity (IC50=0.43 uM) in vitro.

An inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM.

An inhibitor of aldose reductase with IC50 of 28.9 pM.

An inhibitor of histone demethylase..

An inhibitor of LPS-induced TNFαrelease.Pomalidomide is thalidomide derivative that displays inhibition of LPS-induced TNFα release. Shows immunomodulator and anticancer effects.

An inhibitor of the IMP-selective cytosolic 5'-nucleotidase (IC50=2-6 mM).

An insecticide agent that is approved for application on high-value crops such as grapes, tomatoes and other vegetables..

An insecticide agent..