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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DCC4194 Plk1-in-7k Novel polo-like kinase 1 (PLK1) inhibitor
DCC4195 Plx647(ome) Slightly less potent inhibitor of FMS than PLX647 but has better aqueous solubility
DCC4196 Pm00104 Potent anticancer tetrahydroisoquinoline alkaloid, being able to form a covalent bond with the amino group of a guanine in selected triplets of DNA duplexes and eventually give rise to double-strand breaks
DCC4197 Pmed-1 Novel inhibitor of β-catenin signaling, significantly reduced β-catenin activity in hepatoblastoma and several HCC cells
DCC4198 Pmmb-317 Novel potent irriversible dual inhibitor of tubulin and epidermal growth factor receptor (EGFR), inducing the apoptosis of A549 cells in a dose- and time-dependent manner, along with decrease in mitochondrial membrane potential (MMP), production of ROS an
DCC4199 Pmpmease-in L-23 Novel inhibitor of prenylated methylated protein methyl esterase (PMPMEase), a key enzyme in the reversible methylation/demethylation step in the protein prenylation pathway
DCC4200 Pmpmease-in L-28 Novel inhibitor of prenylated methylated protein methyl esterase (PMPMEase), a key enzyme in the reversible methylation/demethylation step in the protein prenylation pathway
DCC4201 P-mppf Dihydrochloride Selective 5-HT1A serotonin receptor antagonist
DCC4202 P-nitro-pifithrin-α Cell-permeable analog of pifithrin-α, potently blocking p53-mediated expression of p21/WAF1 and apoptosis
DCC4203 Pnr-4-20 Novel G Protein-Biased Cannabinoid 1 (CB1) Receptor Agonist
DCC4204 Pnu-292137 Potent inhibitor of CDK2/cyclin A
DCC4205 Pnu-69176e Allosteric modulator of 5-HT(2C)R with no intrinsic agonist activity
DCC4206 Pnz-tmp The first small-molecule approach capable of detecting and controlling engineered cell-cell outputs
DCC4207 Podoverine A Novel microtubule destabilizing natural product from the Podophyllum species
DCC4208 Pol I Inhibitor T5 Novel RNA polymerase I inhibitor, targeting ribosomal DNA G-quadruplexes, potently and selectively inhibiting cell growth by high-affinity binding to G4s in ribosomal DNA, impairing RNA polymerase I (Pol I) elongation, inducing a rapid inhibition of Pol I
DCC4209 Pol7001 Novel macrocycle antibiotic with selective and potent activity against P. aeruginosa
DCC4210 Poloppin-ii Novel modulator of protein-protein interactions of the mitotic polo-like kinases, targeting KRAS mutant xenografts, indicate avenues, acting synergistically with Crizotinib, an inhibitor of the c-MET receptor, against mutant KRAS-expressing cancer cells
DCC4211 Poloxipan Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis
DCC4212 Poly(ethyleneimine) Solution Used for the transfection of a broad variety of cell lines; Antimicrobial; Novel binding agent of diffusive gradients in thin-films (DGT) technique (PEI-DGT)
DCC4213 polygonatone D Novel activator of Adenosine monophosphate (AMP)-activated protein kinase (AMPK)
DCC4214 Polymyxin Antibiotic as a last-line therapy to treat infections caused by these life-threatening 'superbugs'
DCC4215 polyphenol 13b Novel pan-inhibitor of KCa3.1/KCa2 channels
DCC4216 Pom2-c-hmbp Potent Activator of Vγ9Vδ2 T-Lymphocytes; HMBPP ananlog prodrug
DCC4217 Ponfibrate Hypobetalipoproteinemic and Lipid decreasing agent
DCC4218 Poziotinib Hydrochloride Novel pan-human EGF receptor (HER) inhibitor
DCC4219 Ppa250 Novel iNOS homodimerization inhibitor
DCC4220 Pparalpha/delta-in-11 The first reported PPARα/δ dual antagonist
DCC4221 Pparalpha/gamma Agonist N15 Novel dual PPARα/γ agonist, ameliorating insulin resistance and gluconeogenesis in vivo and vitro
DCC4222 Ppi Inhibitor-i Novel inhibitor of protein-protein interaction (PPI), blocking #212121; font-family: BlinkMacSystemFont, -apple-system, "Segoe UI", Roboto, Oxygen, Ubuntu, Cantarell, "Fira Sans", "Droid Sans", "Helvetica Neue", sans-serif; font-size: 14px; font-style: no
DCC4223 pp-ii-a03 Novel insulin mimetic

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