AMPA Receptor Positive Allosteric Modulator

Novel orally bioavailable STAT3 inhibitor

Novel potent orally bioavailable inhibitor of signal transducer and activator of transcription 3 (STAT3)

Novel apigenin analogue, suppressing pancreatic stellate cell proliferation

Novel inhibitor of YycG histidine kinase (HK), showing potent antibiofim activity against Staphylococcus epidermidis

Novel allosteric hexokinase 2 (HK2) modulator, selectively detaching HK2 from the mitochondria

Novel Metformin Derivative; Inhibitor of Proliferation and Invasion of Triple-Negative Breast Cancer Cells

Novel SARS-CoV-2 Main Protease (Mpro) inhibitor, binding to Subsites S1 and S2 (K d =0.69 µM)

Selective Acetylcholinesterase Inhibitor

Novel phosphoramidate prodrug of ddhCTP, effectively reducing titers of Zika and West Nile viruses in cell culture with minimal nonspecific toxicity to host cells

First-in-class inhibitor of protein arginine methyltransferase 5 (PRMT5)

Novel Nerve Agent Reactivator

Potent and highly selective FABP4 inhibitor

Novel antagonist to the inhibitors of apoptosis (IAPs), potentiating cell death in EGFR-overexpressing non-small-cell lung cancer cells

Novel highly potent, selective, and competitive hMAO-B inhibitor with high BBB permeability profile and neuroprotective action (IC 50 = 42 nM; SI > 2375)

Potent stimulator of gamma delta T cells

Protein kinase C partial agonist, targeting the C1 domain, inhibiting cell proliferation, decreasing cell viability and inducing an apoptotic response

Irriversible inhibitor of GSK3

Potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt)

Potent and specific integrin α4ß1 or very late antigen 4 (VLA-4) receptor antagonist, binding to vascular cell adhesion molecule-1 (VCAM-1) and fibronectin

Novel food intake-reducing agent

Potent and selective I ks channel blocker