Cat. No. | Product name | CAS No. |
DC20423 |
JAK1-IN-31
JAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM, less potent for JAK3 (Ki=280 nM) and Tyk2 (Ki=12 nM) and no inhibition on hERG and CYP3A4 (IC50>10 uM). |
1315498-72-6 |
DC11136 |
JAK2 inhibitor G5-7
Featured
JAK2 inhibitor G5-7 is a small molecule, allosteric JAK2 inhibitor that selectively inhibits JAK2-mediated phosphorylation and activation of EGFR and STAT3 by binding to JAK2. |
939681-36-4 |
DC21159 |
JAK3i
JAK3i is a selective, covalent JAK3 kinase inhibitor with IC50 of 0.43 nM, shows high selectivity (>3,000-fold) against the closely related kinase domains in JAK1, JAK2, or TYK2, displays 1,300-fold, 600-fold, and 50-fold over EGFR, ITK, and BTK respectiv |
1918238-72-8 |
DC24028 |
JAK3-IN-1
JAK3-IN-1 is a potent and selective JAK3 inhibitor with IC50 of 4.8 nM. |
1805787-93-2 |
DC20424 |
JAK-IN-35
JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM. |
1400687-19-5 |
DC21160 |
Jarin-1
Jarin-1 is the first small-molecule inhibitor of JAR1 (IC50=3.8 uM) that inhibits jasmonate responses in Arabidopsis thaliana. |
1212704-51-2 |
DC21161 |
JAS239
JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly, prevents choline phosphorylation and induces cell death in breast cancer cell lines. |
1630288-74-2 |
DC12646 |
JBJ-01-162-04
JBJ-01-162-04 is a small molecule targeting the flavivirus E protein with broad-spectrum activity, shows activity against DENV in the infectivity assay with IC90 of 0.1 uM. |
|
DC10934 |
JBJ-16-111
JBJ-16-111 is a small molecule that inhibits dengue virus (DENV) by binding to its envelope protein E.. |
|
DC21163 |
JC-171
JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM. |
2112809-98-8 |
DC22121 |
JCP251
JCP251 is a selective small molecule inhibitor of S. aureus serine hydrolase FphB, effectively reduces infectivity in vivo.. |
62252-26-0 |
DC21164 |
JCR 795b
JCR 795b is a competitive, small molecule inhibitor of choline kinase (ChoK) with in vitro IC50 of 3.5 uM. |
203190-49-2 |
DC9524 |
JDTic (dihydrochloride)
JDTic 2Hcl is a highly selective antagonist for the κ-opioid receptor; without affecting the μ- or δ-opioid receptors. |
785835-79-2 |
DC21455 |
JF-5
JF5 (PAR1 inhibitor JF5) is an allosteric inhibitor of PAR1 that binds to helix 8 of the receptor. |
481687-01-8 |
DC11033 |
JG-231
JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively. |
1627126-59-3 |
DC20425 |
JH-IX-179
JH-IX-179 is a novel highly potent and selective type I ATP competitive pan-FLT3 inhibitor with IC50 of 4 and 10 nM for FLT3-ITD and D835Y, respectively. |
1939104-08-1 |
DC21909 |
JH-T4
JH-T4 is a potent small molecule SIRT2 inhibitor with IC50 of 0.3 uM (sirtuin deacylation activity), increase intracellular K-Ras4a lysine fatty acylation. |
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DC10998 |
JH-VIII-157-02
JH-VIII-157-02 is a potent, orally active, CNS-permeable, second-generation inhibitor of ALK G1202R mutant with IC50 of 2 nM, also shows high potency against a variety of other frequently observed mutants (G1269A, S1206Y, F1174L and C1156Y). |
1639422-97-1 |
DC20426 |
JH-VIII-49
JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM). |
2209084-73-9 |
DC20427 |
JH-XI-10-02
JH-XI-10-02 is a CDK8 PROTAC based on the CDK8 inhibitor JH-VIII-49, induces partial degradation of CDK8 in Jurkat cells with IC50 of 159 nM.. |
2209085-22-1 |
DC22123 |
JI130
JI130 (JI-130) is a specific Hse1 inhibitor that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression. |
2234271-86-2 |
DC20428 |
JKA3 inhibitor 31
JKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM, shows no activity against other JAK kinases. |
1637749-82-6 |