Cat. No. | Product name | CAS No. |
DC21302 |
MK-8325 dihydrochloride
MK-8325 is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively. |
1334314-19-0 |
DC20197 |
MK-8353(SCH900353)
Featured
MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK |
1184173-73-6 |
DC21303 |
MK-8353 hydrochloride
MK-8353 hydrochloride (SCH-900353) is a highly potent, orally bioavailable, dual-specificity ERK1/2 inhibitor with IC50 of 23.0/8.8 nM, respectively. |
1951448-73-9 |
DC21152 |
MK-8591 (Islatravir)
Featured
MK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs, inhibits HIV-1 reverse transcriptase with multiple mechanisms. |
865363-93-5 |
DC12020 |
MK-8722
Featured
MK-8722 is a systemic, Direct Pan-Activator of AMP-Activated Protein Kinase. |
1394371-71-1 |
DC8748 |
MK8745
MK-8745 is a potent and selective Aurora A inhibitor with IC50 of 0.6 nM, more than 450-fold selectivity for Aurora A over Aurora B. |
885325-71-3 |
DC21304 |
MK-8825
MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP. |
1380887-60-4 |
DC21305 |
MK-9470
MK-9470 is a potent, selective cannabinoid CB1 receptor (CB1R) inverse agonist with IC50 of 0.7 nM, 18F MK-9470 has been developed for use in human brain imaging.. |
945850-36-2 |
DC21306 |
MKC9989
MKC9989 is a specific small molecule inhibitor of IRE1α Rnase (Kd=0.84 uM) with potency against the splicing of XBP1 mRNA (EC50=0.33 uM).. |
1338934-20-5 |
DC12523 |
MKK7-COV-13
MKK7-COV-13 (MKK7 Covalen inhibitor 13) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 10 nM, displays >1,000-fold selectivity over MKK4 (IC50>10 uM). |
|
DC12522 |
MKK7-COV-3
Featured
MKK7-COV-3 (MKK7 Covalen inhibitor 3) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 5 nM, displays >1,000-fold selectivity over MKK4 (IC50=7.81 uM), shows EC50 of 1.3 uM for reduction of p-JNK in ICW assays in Beas2B cell line, wit |
|
DC12524 |
MKK7-COV-9
MKK7-COV-9 (MKK7 Covalen inhibitor 9) is a potent, selective, covalent MKK7 inhibitor, displays >1,000-fold selectivity over MKK4. |
|
DC23780 |
MKT-077
Featured
MKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity, binds to Hsp70 family member, mortalin (mot-2), and abrogates its interactions with p53. |
147366-41-4 |
DC21317 |
ML 086 (CID-1674999)
Featured
ML 086 is a potent, specific inhibitor of phosphatase PHOSPHO1 with IC50 of 139 nM, with no activity against TNAP (IC50>100 uM). |
1177148-36-5 |
DC21312 |
ML309
ML 309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM. |
1355446-05-7 |
DC21313 |
ML309 hydrochloride
ML 309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM. |
1355327-02-4 |
DC21323 |
ML 604086
ML 604086 (ML604086) is a potent, selective CCR8 inhibitor that inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations with IC50 of 1.3 uM and 1.0 uM respectively in cellular assays. |
850330-18-6 |
DC21324 |
ML 604440
ML 604440 (ML604440, ML-604440) is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor. |
1140517-08-3 |
DC22412 |
ML00253764
ML00253764 is a non-peptide, brain penetrant melanocortin MC4 receptor (MC4R) antagonist with IC50 of 0.32, 0.81 and 2.12 uM for MC4, MC3 and MC5 receptors, respectively. |
681847-92-7 |
DC22406 |
ML00253764 hydrochloride
ML00253764 is a non-peptide, brain penetrant melanocortin MC4 receptor (MC4R) antagonist with IC50 of 0.32, 0.81 and 2.12 uM for MC4, MC3 and MC5 receptors, respectively. |
1706524-94-8 |
DC23691 |
ML090
Featured
ML090 (ML-090, CCG-44699, Fluoflavin, NSC 179821) is a potent, selecitve inhibitor of NADPH oxidase 1 (NOX1) with IC50 of 90 nM, displays no significant activities against NOX2, 3 and 4 (IC50>10 uM).. |
531-46-4 |
DC21309 |
ML104
ML104 is a novel "bone-seeking" bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9. |
1314124-95-2 |