Cat. No. | Product name | CAS No. |
DC11497 |
IRAK4-IN-28
A novel potent, selective IRAK4 inhibitor with IC50 of 51 nM. |
2196204-23-4 |
DC22938 |
ICA-027243
Featured
A novel potent, selective KCNQ2/Q3 (Kv7.2/Kv7.3) potassium channel opener/activator with EC50 of 0.38 uM.. |
325457-89-4 |
DC22741 |
RY796 R-form
A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively. |
1393441-53-6 |
DC22744 |
RY796 racemate
A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively. |
854165-96-1 |
DC12019 |
RY796
A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively. |
|
DC11613 |
Mcl1-IN-26
A novel potent, selective Mcl-1 inhibitor with IC50 of <3 nM in FRET assays. |
2056238-04-9 |
DC22886 |
TASP 0433864
A novel potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity. |
1431980-60-7 |
DC20441 |
MAO-B inhibitor 8f
A novel potent, selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 29-56 nM. |
947540-06-9 |
DC20467 |
mTOR inhibitor 10
A novel potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1, exhibits cellular potency against mTOR with IC50 of 5 nM. |
1222999-54-3 |
DC11985 |
PSTC
A novel potent, selective Nrf2 activator with pEC50 of 7.7 (inducing of NQO1 specific enzyme activity). |
|
DC23862 |
MET inhibitor Compound 1
A novel potent, selective orally bioavailable MET tyrosine kinase inhibitor with IC50 of <1 nM and 12 nM for unphosphorylated and phosphorylaed MET, respectively. |
1208248-23-0 |
DC22977 |
Lu AF-58027
A novel potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively. |
1255919-63-1 |
DC11559 |
PDE5-IN-6c
A novel potent, selective PDE5 inhibitor with IC50 of 0.056 nM for PDE5A1. |
1448419-13-3 |
DC11969 |
(S)-C33
A novel potent, selective PDE9A inhibitor with IC50 of 11 nM, >45-fold selectivity over other PDE isoforms. |
2066488-39-7 |
DC11585 |
MZ-242
A novel potent, selective Sirt2 inhibitor with IC50 of 0.118 uM. |
1862238-01-4 |
DC11867 |
TBK1 PROTAC 1
A novel potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε. |
2052306-13-3 |
DC21458 |
(S)-PBMC
A novel potent, selective TRPM8 antagonist with IC50 of 15.6 nM (hTRPM8). |
1352138-54-5 |
DC20951 |
DFL 23448
A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold. |
1445753-16-1 |
DC21747 |
tBPC
A novel potent, selective Y4R positive allosteric modulator (EC50=5.1 uM) that potentiates Y4R activation in G-protein signaling and arrestin3 recruitment experiments. |
1942-71-8 |
DC22700 |
DETQ
A novel potent, selective, allosteric and orally active dopamine D1 receptor potentiator with Kb of 26 nM. |
1638667-81-8 |
DC11777 |
PDM-631
A novel potent, selective, brain-penetrable and orally active PDE2A inhibitor with IC50 of 1.5 and 4.2 nM for human and rat PDE2A, respectively. |
2095312-08-4 |
DC22857 |
Pyr-1
A novel potent, selective, cell permeable and ATP competitive LIMK inhibitor. |
83947-94-8 |