Cat. No. | Product name | CAS No. |
DC21431 |
NXL101
NXL101 is a novel quinoline bacterial DNA gyrase and topoisomerase IV inhibitor that shows potent activity against gram-positive bacteria, including methicillin- and fluoroquinolone-resistant strains. |
904302-98-3 |
DC4237 |
NXY-059 (Cerovive)
NXY-059 (Cerovive) is an EGFR and HER2 autophosphorylation inhibitor, against purified EGFR and HER2 of 10.2 and 9.8 nM, respectively. |
168021-79-2 |
DC12712 |
NY0116
NY0116 (NY 0116) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 27.76 uM for hNMUR1 and 13.61 uM for hNMUR2 in intracellular calcium mobilization assays. |
1003000-59-6 |
DC21432 |
NY-0123
NY-0123 is a novel potent Exchange proteins directly activated by cAMP (EPAC) antagonist with IC50 of 0.9 and 2.4 uM for EPAC1 and EPAC2, respectively. |
1801911-70-5 |
DC12713 |
NY0128
NY0128 (NY 0128) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 29.99 uM for hNMUR1 and 10.30 uM for hNMUR2 in intracellular calcium mobilization assays. |
1003000-60-9 |
DC21433 |
NY-0173
NY-0173 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor with IC50 of 4.0 uM for EPAC1.. |
1801911-86-3 |
DC22185 |
O-1602
O-1602 (O1602) is an atypical cannabinoid, potent and selective agonist of GPR55 cannabinoid receptor with EC50 of 13 nM, shows no significant activity for CB1 and CB2 receptors (EC50>30 uM). |
317321-41-8 |
DC20481 |
OADS
OADS is a specific, reversible, small-molecule inhibitor directs against CLC (Chloride Channel) antiporter with Ki of 29 uM, has no specific effect on a CLC channel (ClC-1). . |
5970-15-0 |
DC21435 |
OAT-1746
OAT-1746 is a novel potent, selective, orally active inhibitors of Arginase 1 and 2 (ARG1/2) with IC50 of <50 nM. |
|
DC21436 |
OAT-177
OAT-177 is a potent, selective, orally active acidic mammalian chitinase (AMCase) inhibitor with IC50 of 14 and 19 nM against human and mouse AMCas, respectively, >150-fold selectivity over mCHIT1. |
1799548-33-6 |
DC21437 |
OAT-2068
Featured
OAT-2068 is a potent, selective, orally bioavailable inhibitor of mouse chitotriosidase (mCHIT1) with IC50 of 29 nM, 143-fold selectivity over mAMCase. |
2221950-65-6 |
DC25107 |
OBA-09
OBA-09 is a simple ester of pyruvate and salicylic acid, main metabolites of pyruvate and aspirin, respectively, exerts robust neuroprotective effect in the postischemic brain in vivo. |
856095-68-6 |
DC7217 |
Obatoclax (GX15-070)
Featured
Obatoclax (GX15-070) is Bcl-2 homology domain-3 (BH3) mimetic, antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L). |
803712-67-6 |
DC23421 |
OBE022
OBE022 is a potent, highly selective, orally active antagonist of the contractile PGF2α prostaglandin receptor with Kb of 5.9 nM, shows no activity for other human PG receptors subtypes. |
2005486-32-6 |
DC10134 |
Obicetrapib (AMG-899,TA-8995)
Featured
Obicetrapib is a CETP inhibitor, on the elevation of high-density lipoprotein cholesterol (HDL-C) and reduction of low-density lipoprotein cholesterol (LDL-C), alone and in combination with statin therapy. |
866399-87-3 |
DC21438 |
OBP-801
OBP-801 (YM 753;Spiruchostatin A) is a novel cyclic-peptide-based HDAC inhibitor with IC50 of 2 nM. |
328548-11-4 |
DC9572 |
Octahydrocurcumin
Octahydrocurcumin is a hydrogenated derivatives of curcumin; metabolite of curcumin. |
36062-07-4 |
DC12298 |
Octreotide acetate (SMS 201-995 (acetate))
Featured
Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently. |
79517-01-4 |
DC20635 |
Odalasvir
Odalasvir (ACH-3102, JNJ-64289901) is a potent, second-generation HCV NS5A inhibitor in development for the treatment of hepatitis C.. |
1415119-52-6 |
DC21643 |
ODQ
ODQ (sGC inhibitor ODQ) is a potent, selective, irreversible inhibitor of sGC (soluble guanylyl cyclase). |
41443-28-1 |
DC12135 |
Officinalisinin I
Officinalisinin I is a steroidal saponin, isolated from Anemarrhena asphodeloides. |
57944-18-0 |
DC12526 |
OGG1 inhibitor O8
Featured
OGG1 inhibitor O8 is a potent, selective inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 0.22 uM, displays no significant activity against other DNA Glycosylases (NEIL1, NTH1, Fpg, IC50>50 uM).. |
350997-39-6 |
DC9583 |
Oglemilast
Oglemilast(GRC3886) is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma. |
778576-62-8 |
DC12452 |
OGT inhibitor 4a
OGT inhibitor 4a (OSMI-4 active form) is a novel potent, selective O-linked N-acetylglucosamine transferase (OGT) inhibitor with Kd of 8 nM, the active form of OSMI-4.. |
|
DC21439 |
OHM1
OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM, reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 uM in A549 cells. |
1450995-09-1 |
DC11096 |
Olacaftor
Olacaftor (VX-440, VX440) is a next-generation CFTR corrector, showsthe potential to enhance the amount of CFTR protein at the cell’s surface and for treatment of cystic fibrosis.. |
1897384-89-2 |
DC20193 |
Olanexidine Hydrochloride semihydrate;OPB-2045, OPB-2045G
Olanexidine is a monobiguanide compound with bactericidal activity. |
218282-71-4 |
DC10370 |
Olcegepant hydrochloride
Olcegepant hydrochloride is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and with a Ki of 14.4 pM for human CGRP. |
586368-06-1 |
DC9396 |
Olcegepant
Featured
Olcegepant(BIBN 4096; BIBN 4096BS) is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor(IC50= 0.03 nM). |
204697-65-4 |
DC12241 |
Oleamide
Oleamide is an endogenous fatty acid amide which can be synthesized de novo in the mammalian nervous system, and has been detected in human plasma. |
301-02-0 |
DC8869 |
Oleuropein
Oleuropein is an antioxidant polyphenol isolated from olive leaf. |
32619-42-4 |
DC23082 |
Oliceridine hydrochloride
Oliceridine hydrochloride (Olinvo, TRV130) is a potent, selective, and G protein biased μ opioid receptor (MOR) agonist with pEC50 of 8.1. |
1401028-24-7 |
DC23372 |
Olinone
Featured
Olinone is a selective inhibitor for the BET BRD1 with Kd of 3.4/3.7/8.6 uM for BRD4-BrD1/BRD3-BrD1/BRD2-BrD1, respectively, shows high selectivity over BET BRD2 (Kd>300 uM). |
1770789-37-1 |
DC10299 |
Olumacostat glasaretil
Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). |
1261491-89-7 |
DC10365 |
Omadacycline (tosylate)
Featured
Omadacycline is novel, aminomethyl tetracycline antibiotic being developed for the treatment of community-acquired bacterial infections. |
1075240-43-5 |
DC10324 |
Omapatrilat
Omapatrilat is a dual inhibitor of the metalloproteases ACE and NEP with Ki values of 0.64 and 0.45 nM, respectively. |
167305-00-2 |
DC11335 |
Ombitasvir
Ombitasvir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A). |
1258226-87-7 |
DC11044 |
Omidenepag Isopropyl
Featured
Omidenepag Isopropyl (DE-117, OMDI) is the prodrug of Omidenepag, which is a potent, selective agonist human EP2 receptor; demonstrates excellent IOP-lowering activities following ocular administration in ocular normotensive monkeys, Omidenepag Isopropyl (OMDI) is a clinical candidate for the treatment of glaucoma. |
1187451-19-9 |
DC22463 |
ON 146040
ON 146040 is a potent, dual PI3K/BCR-ABL inhibitor with IC50 of 14/20 nM for PI3Kα/δ , IC50 of 20 nM for BCR/ABL. |
1404231-34-0 |
DC22186 |
ON108110
ON108110 (ON-108110, ON 108110) is a novel multi-kinase inhibitor of protein kinase CK2 (CK2α1/2, IC50=3/2 nM) as well as CDK4/6 (IC50=2-24 nM). |
1415599-79-9 |
DC9927 |
ON1231320
Featured
ON1231320 is a potent selective inhibitor of Polo like kinase 2 (PLK2). |
1312471-39-8 |
DC8137 |
Oncrasin 1
Featured
Oncrasin 1 is a proapoptotic substance. Induces abnormal nuclear aggregation of PKCι and suppressing RNA transcription. |
75629-57-1 |
DC23492 |
ONO-3080573
ONO-3080573 is a potent LPA1 inhibitor with IC50 of 11 nM.. |
1802079-40-8 |
DC8358 |
ONO-4059(Tirabrutinib)
Featured
ONO-4059 is a novel Small Molecule Dual Inhibitor Of Bruton’s Tyrosine Kinase (Btk) and Tec Kinase. |
1351636-18-4 |
DC23689 |
ONO-6126
ONO-6126 is a potent and selective PDE4 inhibitor for the treatment of bronchial asthma and allergic conjunctivitis.. |
401519-28-6 |
DC23490 |
ONO-9780307
ONO-9780307 is a potent LPA1 inhibitor with IC50 of 27 nM.. |
856691-44-6 |
DC23491 |
ONO-9910539
ONO-9910539 is a potent LPA1 inhibitor with IC50 of 22 nM.. |
1802079-45-3 |
DC9610 |
ONO-AE3-208
ONO-AE3-208(AE 3-208) is an EP4 antagonist; suppresses cell invasion, migration, and metastasis of prostate cancer. |
402473-54-5 |
DC22705 |
ONO-DI 004
ONO-DI 004 is a potent, selective EP1 agonist.. |
250605-97-1 |
DC4243 |
ONX-0914
ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. |
960374-59-8 |
DC9404 |
Opicapone
Featured
Opicapone(BIA 9-1067) is a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase. |
923287-50-7 |
DC11905 |
Opiranserin
Featured
Opiranserin (VVZ-149, VVZ-000149) is a potent, selective, mixed glycine GlyT2 transporter blocker (IC50= 0.86 uM), purine P2X3 receptor antagonist (IC50=0.87 uM) and serotonin 5-HT2A receptor antagonist (IC50=1.3 uM). |
1441000-45-8 |
DC7425 |
HQL-79
Orally active and specific inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS) (IC50 = 6 μM). Antiallergic and anti-inflammatory. |
162641-16-9 |
DC10394 |
Org-26576
Org 26576 is a AMPA receptor positive allosteric modulator. |
100044-96-0 |
DC7218 |
Org 27569
Org 27569 is an allosteric modulator of cannabinoid CB1 receptor, induces a CB1 receptor state that is characterized by enhanced agonist affinity and decreased inverse agonist affinity. |
868273-06-7 |
DC20483 |
Org 42599 free base
Org 42599 is a cell-permeant, allosterically binding, small-molecule agonist of luteinizing hormone (LH) receptor that rescues the folding and cell surface expression mutant mutant human LH receptors A593P and S616Y (EC50=70.8 nM).. |
501444-88-8 |
DC21446 |
Org 42599
Org 42599 is a cell-permeant, allosterically binding, small-molecule agonist of luteinizing hormone (LH) receptor that rescues the folding and cell surface expression mutant mutant human LH receptors A593P and S616Y (EC50=70.8 nM).. |
501444-89-9 |
DC21447 |
Orita-13
Orita-13 is potent inhibitor of Migration inhibitory factor (MIF) tautomerase activity with Ki of 17 uM.. |
485-63-2 |
DC8343 |
Oritavancin Diphosphate(LY333328, Orbactiv)
Oritavancin is a lipoglycopeptide with bactericidal activity against gram-positive bacteria. |
937-13-3 |
DC11365 |
Oritavancin (phosphate)
Featured
Oritavancin is a semisynthetic glycopeptide antibiotic that inhibits the growth of Gram-positive bacteria. |
192564-14-0 |
DC23573 |
ORM-10962
ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, significantly reduces inward/outward NCX currents with IC50 of 55 and 67 nM, respectively. |
763926-98-3 |
DC8690 |
ORM-15341(Ketodarolutamide)
Featured
ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct. |
1297537-33-7 |
DC22407 |
Orvepitant
Orvepitant (GW823296) is a potent and selective, brain penetrant NK1 receptor antagonist with pKi of 10.2. |
579475-18-6 |
DC23149 |
Oseltamivir acid
Oseltamivir acid (GS 4071, Ro 64-0802, Oseltamivir carboxylate) is a potent inhibitor of influenza neuraminidase (NA) with Ki of <1 nM for both A and B strains,showed potent activity against COVID-19(SARS-COV-2). |
187227-45-8 |
DC1006 |
OSI-027
Featured
OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. |
936890-98-1 |
DC8554 |
OSI-420
Featured
OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for human EGFR and EGFR autophosphorylation in tumor cells. |
183320-51-6 |
DC21449 |
OSMI-1
Featured
OSMI-1 is a cell-permeable, small molecule O-GlcNAc transferase (OGT) inhibitor with IC50 of 2.7 uM. |
1681056-61-0 |
DC12453 |
OSMI-4
OSMI-4 (OGT inhibitor 4b) is a novel potent, selective, cell-active O-linked N-acetylglucosamine transferase (OGT) inhibitor with EC50 of ~3 uM. |
2260791-14-6 |
DC7220 |
OSU-03012
Featured
OSU-03012(AR-12) is a potent inhibitor of recombinant PDK-1 with IC50 of 5 μM and 2-fold increase in potency over OSU-02067. |
742112-33-0 |
DC21450 |
OSW-1
Featured
OSW-1 is a natural anti-enterovirus and anti-cancer compound that targets oxysterol-binding protein (OSBP) with Ki of 26 and 54 nM for OSBP and ORP4L, respectively. |
145075-81-6 |
DC9443 |
Otamixaban
Otamixaban(FXV673) is a potent (Ki = 0.5 nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa. |
193153-04-7 |
DC9501 |
Otilonium (bromide)
Otilonium Bromide is an antimuscarinic used as a spasmolytic agent. |
26095-59-0 |
DC11257 |
OTS186935
Featured
OTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM, inhibits A549 cell growth with IC50 of 0.67 uM; causes a significant growth inhibitory effect in mouse xenograft models using MDA-MB-231 breast cancer cells as well as A549 lung cancer cells, at 25 mg/kg once daily for 14 days yielded a TGI of 60.8%; attenuates the levels of H3K9me3 in A549 xenograft mouse model. |
2093400-18-9 |
DC11256 |
OTS193320
Featured
OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM. |
2093401-33-1 |
DC11022 |
OUL35
Featured
OUL35 (NSC39047) is a potent and selective inhibitor of mono-ADP-ribosyltransferase PARP10/ARTD10 with IC50 of 330 nM, displays remarkable selectivity towards ARTD10 over other enzymes in the human protein family. |
6336-34-1 |
DC11023 |
OUL35 derivative 32
OUL35 derivative 32 is a potent and selective inhibitor of mono-ADP-ribosyltransferase PARP10/ARTD10 with IC50 of230 nM, rescues HeLa cells from ARTD10-induced cell death.. |
950246-51-2 |
DC22719 |
OUP-16
OUP-16 is a potent H4R agonist with a considerable selectivity over H3R.. |
1038917-11-1 |
DC23553 |
o-vanillin
o-vanillin (C29L. |
148-53-8 |
DC21022 |
OX-14
OX-14 is a highly potent farnesyl pyrophosphate synthase (FPPS) inhibitor with IC50 of 2.46 nM, with significantly lower binding affinity to hydroxyapatite. |
1219126-87-0 |
DC8676 |
Oxadiazon
Oxadiazon is a preemergent herbicide. |
19666-30-9 |
DC5885 |
Oxaliplatin
Featured
Oxaliplatin is a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Oxaliplatin was inspired from the eff |
61825-94-3 |
DC10232 |
Oxybenzone
Oxybenzone is a benzophenone derivative used as a sunscreen agent. |
131-57-7 |
DC20489 |
Oxythiamine chloride hydrochloride
Oxythiamine chloride is a small molecule transketolase inhibitor with Kd of 33 nM, shows functional assay of human transketolase inhibition in HCT-116 cells with EC50 of 26 nM. |
614-05-1 |
DC12352 |
Oxythiamine (Hydroxythiamin)
Oxythiamine, an antimetabolite and a vitamin B1 antagonist, is a well-known thiamine antagonist and inhibitor of transketolase. |
136-16-3 |
DC9445 |
Ozagrel (sodium)
Ozagrel(OKY-046) sodium salt is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor. |
130952-46-4 |
DC11234 |
P053
P053 (P-053, CerS1 inhibitor P053) is a potent, selective, orally active inhibitor of ceramide synthase 1 (CerS1) with IC50 of 0.5 uM, displays >10-fold selectivity for inhibition of CerS2, CerS4, CerS5, and CerS6. |
|
DC20490 |
p32 inhibitor M36
p32 inhibitor M36 is a novel small molecule inhibitor of p32 mitochondrial protein, binds directly to p32 and inhibits p32 association with LyP-1. |
802555-85-7 |
DC23112 |
p38 MAPK-IN-4
p38 MAPK-IN-4 is a potent and selective inhibitor of p38 MAPK with IC50 of 68 nM for p38α, inhibits LPS-induced TNFα release in THP-1 cells with IC50 of 187 nM. |
1006378-90-0 |
DC20001 |
p38α inhibitor 1
p38α inhibitor 1 is a p38α inhibitor extracted from patent WO 2008076265 A1. |
1034189-82-6 |
DC21934 |
P516-0475
P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO (IC50=10 uM). |
1359627-33-0 |
DC23317 |
P53R3
P53R3 is a novel p53 reactivator that restores sequence-specific DNA binding of the endogenously expressed p53(R175H) and p53(R273H) mutants in gel-shift assays. |
922150-12-7 |
DC21520 |
P62-mediated mitophagy inducer
P62-mediated mitophagy inducer (PMI) is a small molecule P62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway. |
1809031-84-2 |
DC22060 |
PAC1
PAC1 (Compound PAC1) is a novel PROTAC antibody conjugate, more potent estrogen receptor-alpha (ERα) degrader compared to PROTAC without antibody conjugation.. |
2158322-33-7 |
DC10399 |
PAC-14028
PAC-14028 is a potent and selective transient receptor potential vanilloid type I (TRPV1) antagonist. |
1005168-10-4 |
DC12200 |
PACAP (6-38), human, ovine, rat TFA
PACAP (6-38), human, ovine, rat is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively. |
|
DC7478 |
Pacritinib
Pacritinib (SB1518) is a potent and selective JAK2 (IC50 = 23 and 19 nM for JAK2WT and JAK2V617F, respectively) and FLT3 (IC(50) = 22 nM) inhibitor with selectivity against JAK1 and JAK3 (IC50= 1280 and 520 nM, respectively). |
937272-79-2 |
DC21408 |
Pactamycin
Pactamycin (NSC 52947) is a potent protein synthesis inhibitor, inhibits protein synthesis at the translocation step on the 70S ribosome, has activity against Gram-positive and Gram-negative bacteria, and broad antitumor, antiviral, and antiplasmodial act |
23668-11-3 |
DC11113 |
Padsevonil
Padsevonil (UCB-0942, UCB0942) is a potential anti-seizure agent that functions as a pre- and post-synaptic inhibitor.. |
1294000-61-5 |
DC21454 |
P11
Featured
PAFAH inhibitor P11 (P11) is a potent, selective platelet-activating factor acetylhydrolases PAFAH1b2 and PAFAH1b3 inhibitor with IC50 of 40 nM and 900 nM respectively. |
942285-55-4 |
DC10292 |
Pagoclone
Pagoclone is an active (+)-enantiomer of the racemate RP 59037. Pagoclone is a partial GABA(A) receptor agonist used for the treatment of panic and anxiety disorders. |
133737-32-3 |
DC10362 |
Palmitelaidic Acid
Palmitelaidic acid is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue. |
10030-73-6 |
DC9897 |
Palmitoylethanolamide
Palmitoylethanolamide(PEA) is an endogenous fatty acid amide and selectively activates PPAR-α in vitro with an EC50 value of 3.1±0.4 μM. |
544-31-0 |
DC20491 |
Palmostatin B
Palmostatin B is a potent Acyl protein thioesterase 1 (APT1. |
1233365-12-2 |
DC20769 |
Pamiparib
Featured
Pamiparib (BGB-290, BGB290) is a highly potent, selective and brain penetrant PARP1/2 inhibitor with potent anti-tumor activity. |
1446261-44-4 |
DC4107 |
Panadiplon (U-78875)
Panadiplon (U-78875) is an anxiolytic drug with a novel chemical structure that is not closely related to other drugs of this type. |
124423-84-3 |
DC20492 |
Pandacostat
Pandacostat is the first nonselective HDAC inhibitor (pan-HDACi) with Ki of 0.12/0.07/0.95/0.18/0.032/1.1/0.5/1.4 uM for HDAC1/2/3/4/5/6/7/8/9, respectively. |
1224158-00-2 |
DC12642 |
pan-PIM inhibitor 17
pan-PIM inhibitor 17 is a potent, selective, orally available inhibitor of Pim kinase with IC50 of 0.8, 5.1 and 1.8 nM for Pim1, 2 and 3, respectively. |
1681021-52-2 |
DC10199 |
Pan-RAS-IN-1
Pan-RAS-IN-1 is a pan-Ras inhibitor that disrupts the interaction of Ras proteins and their effectors. |
1835283-94-7 |
DC9876 |
Pantoprazole
Pantoprazole is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. |
102625-70-7 |
DC12322 |
Papain
Papain is a cysteine protease of the peptidase C1 family, which is used in food, pharmaceutical, textile, and cosmetic industries. |
9001-73-4 |
DC23618 |
PAPTP
PAPTP is a PAP-1 derivative, potent, specific Kv1.3 channel inhibitor with IC50 of 31 nM in Jurkat T lymphocytes by patch-clamp, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM. |
2176486-17-0 |
DC20234 |
PAQ
Featured
PAQ (Compound 4c) is a quinoxaline derivative. PAQ is an orally active neuroprotective agent, which targets dopamine (DA) neurons and activates reticulum endoplasmic ryanodine receptor (RyR) channels, without effects on glia cells. |
943902-10-1 |
DC9537 |
Paradol
Paradol(6-Paradol) is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta); Paradol has been found to have antioxidative and antitumor promoting effects. |
27113-22-0 |
DC10255 |
Parecoxib
Parecoxib is a selective COX2 inhibitor. |
198470-84-7 |
DC6577 |
Paricalcitol
Paricalcitol |
131918-61-1 |
DC9098 |
Paroxetine HCl
Featured
Paroxetine hydrochloride hemihydrate is a antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). |
110429-35-1 |
DC21935 |
PARP10 inhibitor 22
PARP10 inhibitor 22 is a selective, cell-active inhibitor of PARP10 with IC50 of 1.8 uM, exhibits >10-fold selectivity over a large subset of other PARP family members. |
|
DC12450 |
PARP11 inhibitor ITK7
PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor with IC50 of 14 nM, displays >200-fold selectivity over other PARPs. |
|
DC21104 |
PARP14 inhibitor H10
PARP14 inhibitor H10 (H10) is a potent, selective, cell-active PARP14 inhibitor with IC50 of 490 nM, with good selectivity over other PARPs (24-fold and 18-fold over PARP1 and TNKS1, respectively). |
2084811-68-5 |
DC11992 |
PAT-048
PAT-048 (PAT048) is a potent, selective, noncompetitive autotaxin inhibitor with IC50 of 1.1 nM against the lysoPLD activity of human ATX. |
1359983-15-5 |
DC21456 |
PAT-1251
PAT-1251 (PAT 1251, PAT1251) is a potent, selective and orally bioavailable lysyl oxidase-like 2 (LOXL2) inhibitor with IC50 of 0.71 uM in human whole blood assays, with high selectivity over LOX (400-fold) and other amine oxidases. |
2007885-39-2 |
DC11991 |
PAT-505
PAT-505 (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX. |
1782070-85-2 |
DC12184 |
Paullinic acid
Paullinic acid is a long-chain fatty acid that has been detected in multiple biofluids, such as blood and urine. |
17735-94-3 |
DC21457 |
Pax2 inhibitor EG1
Featured
Pax2 inhibitor EG1 (EG1) is a potent, small molecule inhibitor of Pax2 mediated transcription activation, effectively blocks Pax2 activity and DNA binding with Kd of 1.35-1.5 uM; inhibits Pax2 mediated expression with IC50 of 10 uM, and inhibits proliferation of Pax2 positive renal and ovarian cancer cell lines but has little effect on Pax2 negative cancer cells; inhibits embryonic kidney development. |
693241-54-2 |
DC10157 |
PAβN dihydrochloride
Featured
PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor. |
100929-99-5 |
DC22190 |
PBF509
PBF509 (PBF-509, NIR 178) is a novel selective and potent Adenosine A2A Receptor (A2AR) antagonist, antagonizes A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 and 8.2 nM, respectively. |
|
DC11100 |
PBI-4050 sodium
PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively. |
1254472-97-3 |
DC11099 |
PBI-4050
PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively. |
1002101-19-0 |
DC22191 |
PBT434
Featured
PBT434 is a novel quinazolinone compound with effect of lowering cellular iron levels, prevents iron mediated neurodegeneration and α-synuclein toxicity in multiple models of Parkinson disease; inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein, a protein that aggregates in the neuropathology; prevents loss of substantia nigra pars compacta neurons (SNpc), lowers nigral α-synuclein accumulation, and rescues motor performance in mice model of PD. |
1232841-78-9 |
DC21459 |
PC1244
PC1244 is a long acting fungicidal azole that targets A. fumigatus CYP51A and CYP51B, inhibits ergosterol synthesis in A. fumigatus with IC50 of 8 nM. |
2046185-88-8 |
DC21460 |
PC945
PC945 is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively. |
1931946-73-4 |
DC23061 |
L-45
PCAF BRD inhibitor L-45 is a potent, selective, and cell-active PCAF bromodomain inhibitor with Ki of 47 nM in HTRF assays, >4,500-fold selectivity over BRD4. |
2079885-05-3 |
DC23651 |
PCARBTP
PCARBTP is a derivative, potent, specific Kv1.3 channel inhibitor, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM. |
2176486-23-8 |
DC11169 |
PCC0104005
PCC0104005 (PCC-0104005) is a novel modulator of serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2, D3, D4, serotonin 5-HT1A, and 5-HT2A receptors and antagonism at 5-HT2B, 5-HT6, and 5-HT7 receptors. |
1708960-04-6 |
DC12080 |
PCI-33380
PCI-33380 is an irreversible Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe). |
1022899-36-0 |
DC10531 |
PCO371
Featured
PCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1. |
1613373-33-3 |
DC23759 |
PCSK9 modulator 10
PCSK9 modulator 10 is a highly potent, orally active PCSK9 modulator that inhibits PCSK9 production in HepG2 cells with IC50 of 0.036 nM. |
1874254-18-8 |
DC23758 |
PCSK9-IN-7l
PCSK9-IN-7l is a potent, small molecule PCSK9 mRNA translation inhibitor with IC50 of 1.37 uM, shows limited bone marrow toxicity (IC50=27.1 uM).. |
1632250-31-7 |
DC7224 |
PD 123319
Featured
PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM. |
136676-91-0 |
DC21466 |
PD166285
Featured
PD166285 (PD 0166285) is a broad-spectrum receptor tyrosine kinase (RTK) inhibitor that inhibits PDGFR-β, EGFR, and FGFR1 and c-Src with IC50 of 7-85 nM. |
212391-63-4 |
DC12316 |
PD-168077 maleate
Featured
PD-168077 maleate is a selective dopamine D4 receptor agonist, with a Ki of 9 nM. |
630117-19-0 |
DC7571 |
PD173955
Featured
PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. |
260415-63-2 |
DC12219 |
PD1-IN-2
PD1-IN-2 is a PD1 signaling pathway inhibitor, which acts as an immunomodulator. |
1673534-97-8 |
DC21936 |
PD1-PD L1 inhibitor Polaris
PD1-PD L1 inhibitor Polaris is a novel potent, small molecule inhibitor of PD-1/PD-L1 interaction (IC50=0.1-10 nM in ELISA assays) with anti-cancer activity. |
2201132-36-5 |
DC8744 |
PD318088
Featured
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. |
391210-00-7 |
DC21467 |
PDD 00017273
Featured
PDD 00017273 is the first-in-class, selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with Kd, biochemical EC50 of 1.45 nM, 26 nM. |
1945950-21-9 |
DC23693 |
PDE10A-IN-31
PDE10A-IN-31 is a potent, highly selective PDE10A inhibitor with IC50 of 2 nM for both rPDE10A and hPDE10A. |
1639889-98-7 |
DC23701 |
PDE10A-IN-32
PDE10A-IN-32 is a potent, highly selective, brain penetrant PDE10A inhibitor with IC50 of 0.14 nM, displays no significant activity against other PDEs (IC50>1,000 nM).. |
1338795-39-3 |
DC10345 |
PDE1-IN-2
PDE1-IN-2 is an inhibitor of PDE1 extracted from patent WO2016/55618 A1, example 31; has IC50 values of 6, 140 and 164 nM for PDE1C, PDE1B and PDE1A, respectvely. |
1904611-63-7 |
DC12555 |
PDE2 inhibitor 4
PDE2 inhibitor 4 is a potent, selective, orally available inhibitor of PDE2 with IC50 of 2 nM, displays high selectivity versus other PDE isoforms. |
2055160-19-3 |
DC23698 |
PDE4D-IN-26b
PDE4D-IN-26b is a potent, highly selective PDE4D inhibitor with IC50 of 0.6 nM, displays 75-fold lower activity against the PDE4A, B, and C subtypes, also exhibits 18,000-fold decreased potency against other PDE family members. |
1252807-76-3 |
DC23807 |
PDEδ-IN-99
PDEδ-IN-99 is a novel potent K-Ras-PDEδ inhibitor that binds to the farnesyl binding pocket of PDEδ with Kd of 8±4 nM.. |
1841464-21-8 |
DC20047 |
PDGFRα kinase inhibitor 1
PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively. |
2209053-93-8 |
DC9587 |
PDK1 inhibitor
PDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent.. |
1001409-50-2 |
DC11360 |
Pemafibrate
Featured
Pemafibrate is an orally bioavailable and selective agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 1 nM for transcriptional activity), a transcription factor that is essential for regulation of lipid homeostasis. |
848259-27-8 |
DC12178 |
Pemigatinib
Featured
Pemigatinib is a selective FGFR inhibitor in development for the treatment of patients with cholangiocarcinoma. |
1513857-77-6 |
DC12203 |
Pentanoic acid
Pentanoic acid, a short-chain fatty acid, is a product of bacterial metabolism and are associated with allergic skin disorders. Pentanoic acid activates ROCK signaling pathway. |
109-52-4 |
DC12194 |
PEO-IAA
Featured
PEO-IAA is an indole-3-acetic acid (IAA) antagonist. PEO-IAA is an auxin antagonist that binds to transport inhibitor response 1/auxin signaling F-box proteins (TIR1/AFBs). |
6266-66-6 |
DC12301 |
Pepstatin Ammonium (Pepstatin A Ammonium)
Pepstatin Ammonium is a specific aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and he |
|
DC20494 |
Peptide Fz7-21
Peptide Fz7-21 is a potent, selective peptide inhibitor of Frizzled 7 receptor, inhibits exogenous WNT3A stimulated Wnt-β-catenin signaling in HEK293 cells with IC50 of 100 nM. |
|
DC21021 |
Peptide P60
Featured
Peptide P60 (FOXP3 inhibitor P60) is a 15-mer synthetic peptide, cell-permeable inhibitor of FOXP3, binds specifically to FOXP3; inhibits murine and human-derived Treg and improves effector T cell stimulation, overcomes the inhibitory effect of FOXP3 on the activity of the transcription factors NF-κB and NFAT, inhibits upregulation of mRNA for Foxp3 and IL-10 on effector T cells and enhances mRNA for IFN-γ after anti-CD3 stimulation; induces a scurfy-like disease in newborn mice, improves vaccine efficacy in mice model of CT26 tumor and HCV infection. |
1319725-20-6 |
DC20495 |
Perhexiline
Perhexiline is a prophylactic antianginal agent that inhibits carnitine palmitoyltransferase (CPT1/CPT2). |
6621-47-2 |
DC21821 |
Perhexiline maleate
Featured
Perhexiline maleate (WSM 3978G) is a prophylactic antianginal agent that inhibits carnitine palmitoyltransferase (CPT1/CPT2). |
6724-53-4 |
DC12139 |
Perisesaccharide B
Perisesaccharide B is an oligosaccharide isolated from the root barks of Periploca sepium. |
1095261-93-0 |
DC12137 |
Perisesaccharide C
Perisesaccharide C is an oligosaccharide isolated from the root barks of Periploca sepium. |
1311473-28-5 |
DC20708 |
Perlapine
Perlapine (AW-14233. |
1977-11-3 |
DC12059 |
Pertussis Toxin
Featured
Pertussis Toxin is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. |
70323-44-3 |
DC12207 |
Petroselinic acid
Petroselinic acid, a positional isomer of oleic acid, is isolated from the vegetable oil of Coriandrum sativum fruits. |
593-39-5 |
DC12192 |
PF 03709270 (ulopenem etzadroxil)
PF 03709270 is an orally available ester prodrug form of sulopenem, with broad-spectrum antibacterial activity against most gram-positive and gram-negative bacteria. |
1000296-70-7 |
DC10356 |
PF 03716556
PF 03716556 is a potent, and selective acid pump (H+,K+ ATPase) antagonist, with pIC50 value of 6.009. |
928774-43-0 |
DC22930 |
PF-4878691 (3M-852A)
Featured
PF 04878691 (PF 4878691, S 32865, 852A, 3M 001) is a selective TLR7 agonist that potently induces IFN-α and IFN-regulated proteins from human PBMC. |
532959-63-0 |
DC8259 |
PF0477736
Featured
PF 477736 is a CHK inhitor with Ki values of 0.49 and 47 nM for Chk1 and Chk2 respectively. A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity |
952021-60-2 |
DC8147 |
PF 4800567
PF 4800567 is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). |
1188296-52-7 |
DC21516 |
PF 5212372
PF 5212372 (PLA-950, ZPL-521, ZPL 5212372) is a potent, selective inhibitor of cPLA2 (cytosolic phospholipase A2α) with IC50 of 7 nM. |
916136-25-9 |
DC21477 |
PF 6260933 dihydrochloride
Featured
PF 6260933 is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM. |
1883548-86-4 |
DC20027 |
PF 750
Featured
PF 750 is a selective and covalent fatty acid amide hydrolase (FAAH) inhibitor, with IC50s varied from 16.2-595 nM in different pre-incubation times. Covalently modifies the enzyme’s active site serine nucleophile. |
959151-50-9 |
DC11664 |
PF-00446687 hydrochloride
PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM. |
862282-10-8 |
DC11665 |
PF-00446687
PF-00446687(PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM. |
862281-92-3 |
DC3168 |
PF-562271 PHSO3H SALT
Featured
PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. |
939791-38-5 |
DC21500 |
PF-00610355
PF-00610355 (PF 610355) is a potent, selective, and long-acting β2-adrenoreceptor agonist with EC50 of 0.26 nM. |
862541-45-5 |
DC21495 |
PF-02413873
PF-02413873 (PF-2413873) is a potent, selective, fully competitive, and orally active progesterone receptor (PR) antagonist with Ki of 9.7 nM. |
936345-35-6 |
DC23574 |
PF-02575799
PF-02575799 is a highly potent microsomal triglyceride transfer protein (MTP) inhibitor with IC50 of 0.77 nM. |
863491-70-7 |
DC21470 |
PF-03049423
PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM. |
402955-58-2 |
DC21496 |
PF-03382792
PF-03382792 (PF-3382792) is a clinical compound under phase 1 investigation for an unknown indication.. |
1400811-63-3 |
DC23622 |
PF-03463275
PF-03463275 (PF 3463275) ia an orally bioavailable, centrally penetrant, potent, reversible, selective, and competitive inhibitor of the human GlyT1 transporter with Ki of 13 nM. |
1173177-11-1 |
DC23422 |
PF-03654746
PF-03654746 (PF 3654746) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 2.3 nM. |
935840-31-6 |
DC23448 |
PF-03654764
PF-03654764 (PF 3654764) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 1.4 nM. |
935840-35-0 |
DC21483 |
PF03715455
Featured
PF-03715455 is a potent inhaled p38 MAPK inhibitor. PF-03715455 shows some selectivity for p38α over p38β with respective IC50 values of 0.88 and 23 nM. PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 has potential for the treatment of COPD (chronic obstructive pulmonary disease)[1][2].PF-03715455 is a moderate inhibitor of CYP1A2, CYP2C19, and CYP2D6 and a potent inhibitor of CYP’s 2C9 and CYP3A4[2].PF-03715455 treatment shows that the Vss and T1/2 are 0.19 L/kg, 1 hour, respectively[2]. Animal Model: Male CD Sprague Dawley rats (300-450 g)[2] Dosage: 1 mg/kg Administration: I.v. (Pharmacokinetic Analysis) Result: The Vss, and T1/2 were 0.19 L/kg, 1 hour, respectively. |
1056164-52-3 |
DC7059 |
PF-03758309
Featured
PF-03758309 is an orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. |
898044-15-0 |
DC9367 |
PF-03814735
PF-03814735 is a novel, potent, orally bioavailable, reversible small-molecule Aurora kinase inhibitor with IC50 of 0.8, 5, 10 and 22 nM for Aurora A, Aurora B, Flt 1 and FAk, respectively. |
942487-16-3 |
DC23708 |
PF-03882845
PF-03882845 is highly potent, selective, nonsteroidal, orally bioavailable Mineralocorticoid receptor antagonist with IC50 of 4.5 nM. |
1023650-66-9 |
DC21498 |
PF-04191834
PF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM. |
1029317-21-2 |
DC24071 |
PF-04217903 methanesulfonate
Featured
PF-04217903 is a potent, selective, ATP-competitive c-Met kinase inhibitor with Ki of 4.8 nM, inhibits HGF-stimulated tyrosine phosphorylation of wild type c-Met with IC50 of 7.3 nM in cell-based assays. |
956906-93-7 |
DC21479 |
PF-04308515
PF-04308515 (PF 4308515) is a potent glucocorticoid receptor (GR) agonist with anti-inflammatory activity.. |
1206876-95-0 |
DC12550 |
PF-04449613
PF-04449613 (PF04449613) is a potent and selective inhibitor of PDE9.. |
1236858-52-8 |
DC7027 |
Glasdegib(PF-04449913)
Featured
PF-04449913 is a potent and orally bioavailable inhibitor of smoothened with IC50 of 5 nM(Gli-luciferase reporter reporter in C3H10T1/2); the hedgehog pathway inhibitor |
1095173-27-5 |
DC26092 |
PF-04455242 hydrochloride
PF-04455242 is a potent, selective κ-opioid receptor (KOR) antagonist with Ki of 3 nM/21 nM/22 nM for hKOR/rKOR/mKOR, respectively. |
1322001-35-3 |
DC23423 |
PF-04455242
PF-04455242 is a potent, selective κ-opioid receptor (KOR) antagonist with Ki of 3 nM/21 nM/22 nM for hKOR/rKOR/mKOR, respectively. |
1202647-54-8 |
DC21499 |
PF-04531083
PF-04531083 (PF 4531083) is a potent and selective, orally available sodium channel Nav1.8 blocker for treatment of pain. . |
1079400-07-9 |
DC7227 |
PF-04620110
Featured
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. |
1109276-89-2 |