| DC66568 |
Peracetylated GalNAc PEG linker-Amino-1
Featured
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| DC66569 |
GalNAc-L96-Amide
Featured
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| DC66570 |
NAG-37
Featured
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| DC66571 |
Peracetylated GalNAc -C3-Amino-1
Featured
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| DC66572 |
Peracetylated GalNAc PEG linker-Amino-2
Featured
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| DC66573 |
(S)-L-giutamic acid cbz
Featured
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| DC66574 |
Peracetylated GalNAc-L96-1
Featured
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| DC66575 |
Peracetylated GalNAc PEG linker-Acid-2
Featured
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| DC60617 |
dWIZ-1
Featured
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dWIZ-1 is a molecular glue degrader of the WIZ transcription factor that robustly induce HbF in erythroblasts. dWIZ-1 increases CRBNWIZ association with EC50 of 547 nM. |
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| DC60618 |
dWIZ-2
Featured
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dWIZ-2 is a molecular glue degrader of the WIZ transcription factor that robustly induce HbF in erythroblasts. dWIZ-2 shows improved pharmacokinetic (PK) properties than dWIZ-1. |
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| DC60620 |
REM0046127 (REM127)
Featured
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REM0046127 (REM127) is a ReS19-T compound and restores calcium homeostasis and neutralizes tau- and Aβ-driven neurotoxicity. REM127 reduces toxicity and [Ca2+]cyto with EC50 of 15 and 19 nM, respectively but has no effect on tau expression or ATRA-dependent gene transcription. |
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| DC60621 |
MK-1084
Featured
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MK-1084 is an orally bioavailable and low-dose KRAS/G12C covalent inhibitor with IC50 of 1.2 nM (GNE) and 9 nM (p-ERK), respectively. |
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| DC60622 |
KM822
Featured
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KM822 is avselective, noncompetitive modulator of human dopamine transporter (DAT) with IC50 3.7 μM, which shows 30 and 50 folds higher than for human norepinephrine transporter (hNET) and human serotonin transporter (SERT), respectively. |
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| DC60623 |
CNDR-51997
Featured
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CNDR-51997 is a brain-penetrant microtubule alterations-stabilizing small molecule and reduces both Aβ plaque and tau inclusion pathology in established mouse models of Alzheimer's disease. |
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| DC60624 |
OPB-171775
Featured
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OPB-171775 is a non-TKI compound that exhibits significant anticancer activity against gastrointestinal stromal tumor (GIST) regardless of KIT mutation status. OPB-171775 induces targeted cell death by inducing a complex between phosphodiesterase 3A (PDE3A) and Schlafen family member 12 (SLFN12). |
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| DC66576 |
Peracetylated GalNAc-L96-Acid-1
Featured
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| DC66577 |
Propargyl PEG Linker Phosphoramidite
Featured
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| DC66578 |
Cluster
Featured
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| DC66581 |
C3-Phosphoramidites
Featured
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| DC60625 |
NF764
Featured
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NF764 is an analogue of EN83 (CTNNB1 degrader) with improved potency with DC50 of 3.5 nM. NF764 only adducts C619 and shows much more selective than EN83 with 61 significant off-targets. |
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| DC60626 |
EN83
Featured
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EN83 is a monovalent degrader of CTNNB1 that directly and covalently targets CTNNB1 three cysteines C466, C520, and C619, leading to destabilization and degradation of CTNNB1. |
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| DC60627 |
DHSEH |
DHSEH is a sulfonium lipid for lung-specific mRNA delivery. |
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| DC60628 |
DOSEH |
DOSEH is a sulfonium lipid for lung-specific mRNA delivery. |
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| DC60630 |
Bivamelagon (Synonyms: MC-4R Agonist 2)
Featured
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Bivamelagon is a melanocortin receptor agonist. |
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| DC66585 |
Turbinaric acid
Featured
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Turbinaric acid is a moderately cytotoxic secosqualene carboxylic acid that is isolated from the brown alga Turbinaria ornata. |
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| DC66586 |
IDH1 Inhibitor 8
Featured
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IDH1 Inhibitor 8 (91) is isocitrate dehydrogenase 1 (IDH1) inhibitor. IDH1 Inhibitor 8 can be used for the research of cancer. |
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| DC66587 |
SDPC |
SDPC (DHA-PC) is a new generation of omega-3 lipids, which contains an ester bond linking DHA at the sn-2 position of phospholipid. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine exerts anti-angiogenesis effect through activating PPARγ. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine significantly declines the proliferation, migration, tube formation of human umbilical vein endothelial cells. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine has the potential for anti-tumor angiogenesis research. |
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| DC60631 |
T-10418
Featured
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T-10418 is a potent and selective G2A agonist with EC50 of 0.82 μM. T-10418 exhibits higher potency than the reference and natural ligand 9-HODE and high selectivity among G protein-coupled receptors. T-10418 is a suitable candidate for in vivo studies on therapeutic potential of G2A agonism. |
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| DC60633 |
AZ9567
Featured
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AZ'9567 is a potent inhibitor of MAT2A with pIC50 of 8.2. in vitro with excellent preclinical pharmacokinetic properties. AZ'9567 shows robust antitumor response in the MTAP KO HCT116 model. |
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| DC60634 |
LL-K12-18
Featured
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LL-K12-18 is a dual-site molecular glue for CDK12-DDB1 complex with EC50 of 0.37 nM. LL-K12-18 shows an 80-fold enhanced potency than SR-4835 in MDA-MB-231 cells and with a 307-fold boost potency (EC50 = 0.03 nM) in MDA-MB-468 cells, while the degradation efficiency (DC50 = 0.38 nM) increased 50-fold. |
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