| DC10953 |
DZ-2384 |
DZ-2384 (DZ2384) is a microtubule-targeting agent, exhibits potent antitumor activity in models of multiple cancer types. |
|
| DC8277 |
E-2012
Featured
|
E 2012 is a potent γ-secretase modulator. |
|
| DC20985 |
E 6201 |
E 6201 (E6201) is a potent, selective, dual MEK1 and MEKK1 inhibitor, inhibits LPS-induced TNFα transcription with IC50 of 50 nM. |
|
| DC20986 |
E 6446
Featured
|
E 6446 is a novel orally available small molecule inhibitor of TLR7 and TLR9 with IC50 of 1.78 uM and 0.01 uM, respectively. |
|
| DC11213 |
E1231
Featured
|
E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα). |
|
| DC10895 |
E260
Featured
|
E260 is a Fer/FerT kinase inhibitor. |
|
| DC20370 |
E3 Ligand-Linker Conjugate 1 |
E3 Ligand-Linker Conjugate 1 is an E3 ligand- Linker Conjugate for PROTAC. |
|
| DC11570 |
E3 Ligand-Linker Conjugate 5 |
E3 Ligand-Linker Conjugate 5 is an E3 ligase ligand-linker conjugate for PROTAC.. |
|
| DC12249 |
E3 ligase Ligand 1 dihydrochloride |
E3 ligase Ligand 1 dihydrochloride is a Hippel-Landau (VHL) E3 ligase-binding moiety based on PROTAC technology. |
|
| DC22335 |
E3 ligase Ligand 1A
Featured
|
E3 ligase Ligand 1A is a ligand of E3 ligase, used in PROTAC technology; E3 ligase Ligand 1A can be used in the research of cancer.
(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) |
|
| DC11565 |
E3 Ligase Ligand 2
Featured
|
E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology. |
|
| DC11571 |
E3 Ligase Ligand 3
Featured
|
E3 ligase Ligand 3 is a ligand of E3 ligase, used in PROTAC technology. |
|
| DC12674 |
E3 ligase Ligand-Linker Conjugates 16
Featured
|
E3 ligase Ligand-Linker Conjugates 16 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
|
| DC12675 |
E3 ligase Ligand-Linker Conjugates 17
Featured
|
E3 ligase Ligand-Linker Conjugates 17 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
|
| DC12141 |
E3 Ligase Ligand-Linker Conjugates 22
Featured
|
E3 Ligase Ligand-Linker Conjugates 22 incorporates an E3 ligase ligand and a linker, can be used for the treatment of EZH2-mediated cancer. |
|
| DC12092 |
E3 Ligase Ligand-Linker Conjugates 23 TFA |
E3 Ligase Ligand-Linker Conjugates 23 (TFA) is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
|
| DC12181 |
E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate |
E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
|
| DC8404 |
E3330
Featured
|
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. |
|
| DC7128 |
Lucitanib(E3810)
Featured
|
E-3810 is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. |
|
| DC9595 |
E-4031
Featured
|
E-4031 is a benzenesulfonamide antiarrhythmic agent; blocks the ATP-sensitive potassium channel.
|
|
| DC8533 |
E5555 hydrobromide |
E5555 shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC values of 0.064 and 0.031 μM respectively. |
|
| DC23442 |
E-5842 |
E-5842 is a preferential sigma-1 receptor ligand, demonstrates potential atypical antipsychotic effects in vivo. |
|
| DC23416 |
E-5842 hydrochloride |
E-5842 is a preferential sigma-1 receptor ligand, demonstrates potential atypical antipsychotic effects in vivo. |
|
| DC10141 |
E6005
Featured
|
E6005 potently and selectively inhibited human PDE4 activity with an IC50 of 2.8 nM and suppressed the production of various cytokines from human lymphocytes and monocytes with IC50 values ranging from 0.49 to 3.1 nM. |
|
| DC9387 |
E-64
Featured
|
E-64 is a natural, potent, and irreversible inhibitor of cysteine proteases; IC50 values for inhibiting cathepsins K, S, and L, in vitro, are 1.4, 4.1, and 2.5 nM, respectively.
|
|
| DC10520 |
E6446 dihydrochloride
Featured
|
E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM. |
|
| DC10126 |
E-64c
Featured
|
E-64c is a synthetic analog of E-64, a potent and irreversible cysteine protease inhibitor isolated from Aspergillus japonicus. |
|
| DC8485 |
E-64d(Aloxistatin)
Featured
|
E-64D is an inhibitor of cathepsins B and L; also thought to inhibit calpain,showed a potent activity for COVID-19(SARS-COV-2)with EC50: MERS-COV(1.275),SARS-COV(0.760) |
|
| DC23728 |
E64FC26 |
E64FC26 is a highly potent pan-style inhibitor of Protein Disulfide Isomerase (PDI) with IC50 of 1.9 uM (PDIA1), also inhibits all other members of the PDI family, including PDIA3, PDIA4, TXNDC5, and PDIA6. |
|
| DC23360 |
E67-2 |
E67-2 is a potent and selective inhibitor of H3K9 Jumonji demethylase KIAA1718 (KDM7A) with IC50 of 3.4 uM. |
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