| DC23469 |
MLN 3897 |
MLN 3897 is a potent, specific and orally active antagonist of CCR1 with IC50 of 0.8 nM in competition binding assays, 500-fold selectivity over CCR5. |
|
| DC7469 |
MLN0905 |
MLN0905 is a mall-molecule and potent inhibitor of PLK1 with IC50 of 2 nM. |
|
| DC7198 |
MLN-120B
Featured
|
MLN120B is a potent and effective IKKbeta inhibitor. |
|
| DC5086 |
Ixazomib(MLN2238)
Featured
|
MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. |
|
| DC23447 |
MLN3126 |
MLN3126 (MLN 3126, MLN-3126) is a potent, selective, orally available CCR9 antagonist with IC50 of 6.3 nM (CCL25-induced calcium mobilization). |
|
| DC12255 |
MLN-4760
Featured
|
MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM). |
|
| DC5176 |
Pevonedistat
Featured
|
MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM. |
|
| DC9365 |
MLN8054
Featured
|
MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM; exhibits more than 40-fold selective for Aurora A than Aurora B.
|
|
| DC2016 |
MLN8237 (Alisertib)
Featured
|
MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM. |
|
| DC5089 |
Ixazomib Citrate (MLN-9708)
Featured
|
MLN-9708 is a proteasome inhibitor, which inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome. |
|
| DC10221 |
MLR-1023 |
MLR-1023 is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals. |
|
| DC21328 |
MLS 0038949 |
MLS 0038949 is a potent, selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 0.19 uM, shows no activity against IAP and PLAP (IC50>100 uM). |
|
| DC21329 |
MLS 0263839
Featured
|
MLS 0263839 is a potent, specific inhibitor of the phosphatase PHOSPHO1 with IC50 of 0.14 uM, shows minimal cross-inhibition of TNAP and no inhibition of ENPP1 activity. |
|
| DC21326 |
MLS-0322825 |
MLS-0322825 is a novel potent low-molecular-weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 3.3 uM. |
|
| DC22159 |
MLS-0437605 |
MLS-0437605 is a specific inhibitor of dual-specificity phosphatase 3 (DUSP3) with IC50 of 3.7 uM, 7-fold selectivity over USP22 and >4-fold selectivity over other 10 PTPs (HePTP, TCPTP, PTP1B, etc.). |
|
| DC22160 |
MLS1082 |
MLS1082 is a novel positive allosteric modulator of the D1 dopamine receptor, potentiatse dopamine-stimulated G-protein- and β-arrestin-mediated signaling and increase the affinity of dopamine for the D1 receptor with low micromolar potencies.. |
|
| DC26042 |
MLS-1547 |
MLS-1547 is a G protein-biased agonist of dopamine D2 receptors (EC50 = 0.37 μM in a calcium mobilization assay). |
|
| DC11165 |
MLS6585 |
MLS6585 is a novel positive allosteric modulator of the D1 dopamine receptor, potentiatse dopamine-stimulated G-protein- and β-arrestin-mediated signaling and increase the affinity of dopamine for the D1 receptor with low micromolar potencies.. |
|
| DC22161 |
MLT-747
Featured
|
MLT-747 (MLT747) is a potent, selective, allosteric inhibitor of MALT1 paracaspase with IC50 of 14 nM. |
|
| DC22162 |
MLT-748
Featured
|
MLT-748 (MLT748) is a potent, selective, allosteric inhibitor of MALT1 paracaspase with IC50 of 5 nM, does not show inhibitory activity against 22 other tested human proteases (IC50>100 uM). |
|
| DC12083 |
MM 07
Featured
|
MM 07 is a biased apelin receptor agonist, with a KD of 300 nM in CHO-K1 cells and a KD of 172 nM in human heart. |
|
| DC7562 |
MM-102
Featured
|
MM-102 is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM. |
|
| DC8264 |
MM-41 |
MM41 is a quadruplex-interactive compound which binds strongly to the quadruplexes encoded in the promoter sequences of the BCL-2 and k-RAS genes. |
|
| DC20084 |
MM-589 |
MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM. |
|
| DC11425 |
MMAE-(PEG)4-DBCO
Featured
|
MMAE-(PEG)4-DBCO is made by MMAE conjugated to DBCO-(PEG)4 linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. |
|
| DC20458 |
MMBO |
MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively. |
|
| DC21921 |
MMK7 inhibitor 4a |
MMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7, displays >800-fold selectivity over EGFR-WT and EGFR-L858R/T790M. |
|
| DC20459 |
MMP13-IN-24f |
MMP13-IN-24f is a potent, selective, and orally active MMP-13 inhibitor with IC50/Ki of 0.5/0.19 nM, shows no activity against MMP-1 or TACE (IC50>10 uM). |
|
| DC20460 |
MMP13-IN-31f |
MMP13-IN-31f is a highly potent, selective, orally bioavailable MMP-13 inhibitor with IC50 of 0.036 nM. |
|
| DC11368 |
MMP-2/MMP-9 Inhibitor II |
MMP-2/MMP-9 inhibitor II is a dual inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 17 and 30 nM, respectively). |
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